UFundo lwe-HR-HPV mRNA ye-15-Ichonga ubukho kunye NOMSEBENZI we-HR-HPV

Umhlaza womlomo wesibeleko, ongoyena nobangela uphambili wokubhubha kwabasetyhini kwihlabathi liphela, ubangelwa ikakhulu lusulelo lwe-HPV. Ikhono le-oncogenic losulelo lwe-HR-HPV luxhomekeke kwintetho eyongeziweyo ye-E6 kunye ne-E7 genes. Iiprotheni ze-E6 kunye ne-E7 zibophelela kwi-tumor suppressor proteins p53 kunye ne-pRb ngokulandelanayo, kwaye ziqhube ukwanda kweeseli zomlomo wesibeleko kunye nokuguqulwa.

Nangona kunjalo, uvavanyo lwe-HPV DNA luqinisekisa ubukho bentsholongwane, ayicaluli phakathi kosulelo olufihlakeleyo nolukhuphela ngokusebenzayo. Ngokwahlukileyo, ukufunyaniswa kwe-HPV E6 / E7 mRNA okubhaliweyo kusebenza njenge-biomarker ecacileyo ye-virtual oncogene expression, kwaye ke, i-predictor echanekileyo ye-intraepithelial neoplasia ephantsi yomlomo wesibeleko (CIN) okanye i-carcinoma eyingozi.

HPV E6/E7 mRNAUvavanyo lubonelela ngezibonelelo ezibalulekileyo kuthintelo lomhlaza womlomo wesibeleko:

• Uvavanyo loMngcipheko oluchanekileyo: Ukuchonga usulelo olusebenzayo, olusemngciphekweni ophezulu we-HPV, lubonelela ngovavanyo oluchanekileyo ngakumbi kunovavanyo lwe-HPV DNA.
• Uvavanyo olusebenzayo: Ukhokela oogqirha ekuchongeni izigulane ezifuna uphando olongezelelweyo, ukunciphisa iinkqubo ezingeyomfuneko.
• Isixhobo sokuHlola esinokubakho: Singasebenza njengesixhobo sokuhlola esizimeleyo kwixesha elizayo, ngakumbi kubantu abasengozini enkulu.
• Iindidi ezili-15 ze-Human Papillomavirus E6/E7 ye-Gene mRNA Detection Kit (Fluorescence PCR) esuka kwi-#MMT, ukufumanisa ngokomgangatho isiphawuli sosulelo olunokubakho oluqhubekayo lwe-HR-HPV, sisixhobo esiluncedo ekuhlolweni kwe-HPV kunye/okanye nolawulo lwesigulane.

Iimpawu zeMveliso:

• Ukhuseleko olupheleleyo: Iintlobo ezili-15 ze-HR-HPV ezinxulumene nomhlaza womlomo wesibeleko ezigqunyiweyo;
• Uvelwano olugqwesileyo: iikopi ze-500 / mL;
• Ukucaciswa okuphezulu: Akukho msebenzi wesiphambano kunye ne-cytomegalovirus, i-HSV II kunye ne-DNA ye-genomic yabantu;
• Ukonga imali: Iithagethi zovavanyo ezinxibelelene ngokusondeleyo nesifo esinokwenzeka, ukunciphisa iimviwo ezingeyomfuneko ngeendleko ezongezelelweyo;
• Ukuchaneka okugqwesileyo: IC kuyo yonke inkqubo;
• Ukuhambelana okubanzi: Ngeenkqubo zePCR eziqhelekileyo;