I-Clostridioides difficile isengomnye wemiba ebalulekileyoezona zizathu zibalulekileyo zesifo sohudo esibangelwa kukunakekelwa kwempilokwihlabathi liphela. Umthwalo ubaluleke kakhulu kwizigulane ezindala, abantu abalaliswe esibhedlele, abahlali bezibonelelo zokhathalelo lwexesha elide, kunye nezigulane ezifumana amayeza okubulala iintsholongwane asebenzisa i-broad-spectrum.
Sekunjalo, ukufumanisa isifo se-C. difficile (CDI) kuzisa umngeni owahlukileyo.
Ngokungafaniyo neentsholongwane ezininzi zesisu, i-C. difficileisifo esinobungoziezinokuthi zihlale emathunjini ngaphandle kokubangela isifo. Ukungabonisi zimpawu kuhlala kubonwa kwiindawo zonyango, oko kuthetha ukuba ubukho besilwanyana kuphela akuthethi ukuba sinesifo esisebenzayo.
Lo mahluko phakathi kokungena ekoloniyalini kunye nosulelo uphakathi kweyona nto iphambili ekuxilongweni kwe-CDI yanamhlanje.
Yintoni iCDI?
Isifo sezonyango siphuhla xa iintlobo ze-toxigenic zivelisa ityhefu eyonakalisa i-mucosa yamathumbu, nto leyo ekhokelela kwiimpawu ezifana nezi:
- · Urhudo olungachazwanga
- · Intlungu zesisu
- · Ifiva
- · I-Leukocytosis
- · Isifo seKholitis
Ngokwengxelo yohlaziyo luka-2021 yesikhokelo se-European Society of Clinical Microbiology and Infectious Diseases (ESCMID), uvavanyo lwelabhoratri kufuneka lwenziwe ikakhulu kwizigulana ezinesifo sohudo esibalulekileyo esibonisa i-CDI.
Esi sikhokelo sichaza urhudo njengendle ekhululekileyo kathathu okanye ngaphezulu kwiiyure ezingama-24 kwaye sigxininisa ukuba iziphumo zelebhu kufuneka zihlale zikhoitolikwe kunye nokubonakaliswa kweklinikhi.
Iziphumo zelebhu ezilungileyo zodwa akufuneki zilinganiswe ngokuzenzekelayo neCDI.
I-ESCMID: Ukudibanisa uVavanyo lweKliniki kunye noVavanyo lweLebhu
Ukuphucula ukuchaneka kokuxilonga ngelixa kunciphisa ukuxilonga okugqithisileyo, i-ESCMID icebisa indlela yokuxilonga ethatha amanyathelo amaninzi.
Isigaba sokuqala sokuhlola singasebenzisa:
- · I-Glutamate dehydrogenase (GDH), okanye
- · Uvavanyo lokwandiswa kwe-Nucleic Acid (NAAT)
Zombini ezi ndlela zibonelela ngobuntununtunu obuphezulu bokuchonga izigulana ezine-C. difficile.
Xa kuthelekiswa ne-GDH,I-NAAT ibonelela ngobuchule obuphuculweyo ngokufumanisa iijini ezinxulumene netyhefu ezithwalwa ziintlobo zetyhefuendaweni yokuchonga nje ubukho bento ephilayo.
Nangona kunjalo, i-ESCMID ikwaphawula ukuba ukuthembela kwi-NAAT yodwa kunokukhokelela ekuxilongweni okugqithisileyo kuba ii-toxin genes zinokufunyanwa kubantu abathwala izifo okanye izigulane ezingenazo izifo ezichaphazela impilo yazo.
Ngenxa yesi sizathu, iziphumo zovavanyo ezilungileyo zitolikwa kakuhle kunye neziphumo zovavanyo lwe-toxin immunoassay kunye neziphumo zeklinikhi.
Le ndlela inceda ukwahlula:
- · I-CDI esebenzayo
- · Ukungena kweempawu zokukhulelwa
- · Usulelo olukwinqanaba lokuqala olufuna uvavanyo olongezelelekileyo lweklinikhi
Uvavanyo lwe-CDI oluhambelana neSikhokelo oluXhasiweyo
Ukuxhasa iilabhoratri ezisebenzisa uvavanyo lweemolekyuli kwiindlela zokuxilonga ze-CDI, iMacro kunye neMicro-Test zibonelela ngeIkhithi yokuFumana iNucleic Acid yeClostridium difficile Toxin A/B Gene (Fluorescence PCR).
Uvavanyo lubona ngokuthe ngqoi-tcdAkwayei-tcdBiijini ezivelaiisampulu zendle ezingekazalwa, okuvumela ukuchongwa ngokukhawuleza kweentlobo ze-toxigenic C. difficile.
Iingenelo eziphambili:
-Uvakalelo oluphezulu kunye ne-LoD ephantsi njenge:200 CFU/mL/2,000 iikopi/mL, okuvumela ukufunyanwa okuthembekileyo kweentlobo ze-toxigenic ezikumgangatho ophantsi.
-Ukujonga ityhefu A (i-tcdAkunye netyhefu B (i-tcdB) zezakhi zofuzo, olu vavanyo luchonga ngokukodwa iintlobo ezikwaziyo ukuvelisa izinto eziphambili ze-virulence ezinxulumene ne-CDI.
- Ukuhlanganiswa kwe-Flexible Workflow: iyahambelana namaqonga e-PCR aqhelekileyo ngexesha langempela kunye noVavanyo oluZenzekelayo olupheleleyo kwi-Eudemon AIO 800
-Iqinisekiswe yi-IVDR, ebonisa ukuthobela iimfuno ezingqongqo ze-European In Vitro Diagnostic Regulation kunye nokuxhasa iilabhoratri kwiimarike zaseYurophu nakwamanye amazwe.
Ukunika amandla izigqibo zeklinikhi ezingcono
Ukuxilongwa ngokuchanekileyo kwe-CDI kufuna okungaphezulu kokuchongwa njeC. nzimaIfuna ukuhlanganiswa kweempawu zeklinikhi, iziphumo zelebhu, kunye nokuqonda umahluko phakathi kokungena ekoloni kunye nosulelo.
Ihambelana neengcebiso ze-ESCMID, i-NAAT enobuthathaka obuphezulu idlala indima ebalulekileyo ekuchongeni ityhefuC. nzimaiintlobo zeengxaki njengenxalenye yesicwangciso esibanzi sokuxilonga i-CDI.
Ngezisombululo zayo zovavanyo lweemolekyuli eziqinisekisiweyo yi-IVDR, iMacro & Micro-Test izibophelele ekuncedeni iilabhoratri ukuba zinike iziphumo ezikhawulezayo nezithembekileyo ezixhasa izigqibo zeklinikhi ezinolwazi, amanyathelo okulawula usulelo asebenzayo, kunye neziphumo eziphuculweyo zezigulane.
Ixesha leposi: Juni-25-2026