Xa umntwana esiba neempumlo ezivuzayo, ukhohlokhohlo, okanye umkhuhlane, abazali abaninzi ngokuzenzekelayo bacinga ngengqele okanye umkhuhlane. Nangona kunjalo isabelo esibalulekileyo sezi zigulo zokuphefumla-ingakumbi ezona zinzima kakhulu-zibangelwa yi-pathogen eyaziwa kancinci:I-Human Metapneumovirus (hMPV).
Ukusukela oko yafunyaniswayo ngo-2001, i-hMPV iye yavela njengelona galelo liphambili kwihlabathi jikelele kusulelo lokuphefumla, engachaphazeli abantwana kuphela kodwa nabantu abadala kunye nabantu abakhubazekileyo.
Ukuqaphela impembelelo yokwenyani ye-hMPV kubalulekile—hayi ukonyusa uloyiko, kodwa ukomeleza ulwazi, ukuphucula ukwenziwa kwezigqibo zekliniki, kwaye ekugqibeleni kuncitshiswe umthwalo kwiinkqubo zokhathalelo lwempilo kunye nabemi abasesichengeni.
Umlinganiselo oNgaqikelelwayo we-hMPV
Nangona ihlala ingcwatywa phakathi kweendidi ezibanzi ezifana "nosulelo lwentsholongwane yokuphefumla," idatha ityhila ukubaluleka kwempilo yoluntu ye-hMPV:
Unobangela ophambili wabantwana:
Ngo-2018 kuphela, i-hMPV yayinoxanduvangaphezu kwezigidi ezili-14 usulelo olubukhali olusezantsi lokuphefumlakwayeamakhulu amawaka esibhedlelekubantwana abangaphantsi kweminyaka emihlanu.
Ehlabathini lonke, isoloko ichongwa njengeokwesibini eyona nto ixhaphakileyo ngunobangela wentsholongwane wenyumoniya ebuntwaneni, emva kwe-Respiratory Syncytial Virus (RSV).
Umthwalo obalulekileyo kubantu abadala:
Abantu abadala abaneminyaka engama-65 nangaphezulu bajongene nomngcipheko omkhulu wokulaliswa esibhedlele ngenxa ye-hMPV, ehlala ibonakalisa inyumoniya kunye noxinzelelo olukhulu lokuphefumla. Iincopho zonyaka-ngokuqhelekileyo kwiekupheleni kobusika kunye nentwasahlobo-inokubeka uxinzelelo olongezelelweyo kwiinkonzo zempilo.
Umngeni wokosuleleka kunye:
Ngenxa yokuba i-hMPV ihlala ijikeleza ecaleni komkhuhlane, i-RSV, kunye ne-SARS-CoV-2, usulelo oluhlangeneyo luyenzeka kwaye lunokukhokelela kwisigulo esiqatha ngakumbi ngelixa lunzima ukuxilongwa kunye nonyango.
Kutheni i-hMPV Ingaphezulu “Kunokubanda nje”
Kubantu abadala abaninzi abasempilweni, i-hMPV inokufana nokubanda okungephi. Kodwa ubungqongqo bokwenyani bentsholongwane bulele kuyoukuthambekela ukosulela iphecana lokuphefumla elisezantsikunye nefuthe layo kumaqela athile asemngciphekweni omkhulu.
Uluhlu Olubanzi Lwezigulo
I-hMPV inokubangela:I-bronchiolitis; Ukukrala kwemiphunga; Ukugqithiswa ngokukhawuleza kwe-asthma; Ukuba mandundu kwesifo esingapheliyo semiphunga (COPD)
Abemi basemngciphekweni omkhulu
-Iintsana kunye nabantwana abancinci:
Iindlela zabo zomoya ezincinci zisengozini enkulu yokudumba kunye nokuqokelelana kwe-mucus.
-Abantu Abadala:
Ukunciphisa i-immunity kunye nezifo ezingapheliyo zonyusa ukuchaphazeleka kwiingxaki ezinzima.
-Izigulana ezine-Immunocompromised:
Aba bantu banokuba nosulelo oluthatha ixesha elide, oluqatha, okanye oluphindaphindayo.
Umceli mngeni oPhambili: Umsantsa wokuxilonga
Esona sizathu siphambili sokuba i-hMPV ihlale ingaqatshelwa kakuhle siukungabikho kwesiqhelo, uvavanyo oluthile lwentsholongwanekwiindawo ezininzi zeklinikhi. Iimpawu zayo ziphantse zingabonakali kwezinye iintsholongwane zokuphefumla, ezikhokelela ku:
-Uphoswe okanye ulibazisekile ukuxilongwa
Amatyala amaninzi abhalwe ngokulula “njengosulelo lwentsholongwane.”
-Ulawulo olungafanelekanga
Oku kunokubandakanya imigqaliselo engeyomfuneko yamayeza okubulala iintsholongwane kunye namathuba alahlekileyo okhathalelo olufanelekileyo lwenkxaso okanye ulawulo losulelo.
-Ukujongelwa phantsi koMthwalo weZifo oyinyaniso
Ngaphandle kwedatha yoxilongo echanekileyo, iimpembelelo ze-hMPV zihlala zifihlwe kakhulu kwiinkcukacha-manani zempilo yoluntu.
I-RT-PCR ihlala ingumgangatho wegolide wokufunyanwa, ukugqamisa imfuno yokufikelela ngakumbi kunye nezisombululo zokuvavanya iimolekyuli.
Ukuvala iSikhewu: Ukuguqula ulwazi lube yiNtshukumo
Ukuphucula iziphumo ze-hMPV kufuna zombini ulwazi olunzulu lwezonyango kunye nokufikelela kuxilongo olukhawulezayo, oluchanekileyo.
1. Ukomeleza ukuSoleka kweKlinikhi
Ababoneleli ngezempilo kufuneka baqwalasele i-hMPV xa bevavanya izigulana-ingakumbi abantwana abancinci, abantu abadala abadala, kunye nabantu abakhubazekileyo-ngexesha lokuphefumla okuphezulu.
2. UVavanyo lweSicwangciso soDidiagnostic
Ukuphumeza ngokukhawuleza, uvavanyo lwemolekyuli ezininzi zenza ukuba:
Ukhathalelo lweSigulana ekuJoliswe kuso
Unyango olululo lwenkxaso kunye nokunciphisa ukusetyenziswa okungafunekiyo kwe-antibiotic.
Ulawulo olusebenzayo losulelo
Ukudibana kwangexesha kunye nokubekwa wedwa ukuthintela ukuqhambuka kwesibhedlele.
ULindo olongezelelweyo
Ukuqonda okucacileyo kokujikeleza iintsholongwane zokuphefumula, ukuxhasa ukulungela impilo yoluntu.
3. Izisombululo zoDiagnostic ezitsha
Itekhnoloji efana neI-AIO800 iAutomated ngokupheleleyo yeNucleic Acid Systemlungisa ngqo izithuba ezikhoyo.
Le "sample-in, impendulo-out" iqonga lichongahMPV ecaleni kwezinye iipathogens ezixhaphakileyo zokuphefumla-kubandakanya iintsholongwane zomkhuhlane, i-RSV, kunye ne-SARS-CoV-2-ngaphakathimalunga nemizuzu engama-30.
Ukuhamba komsebenzi okuSebenzayo ngokupheleleyo
Ngaphantsi kwemizuzu emi-5 yezandla ngexesha. Akukho mfuneko yabasebenzi abanezakhono kwiimolekyuli.
- Iziphumo ezikhawulezayo
Ixesha lokuguqula imizuzu ye-30 lixhasa izicwangciso zeklinikhi ezingxamisekileyo.
- 14Ukufunyanwa kwePathogen Multiplex
Ukuchongwa ngaxeshanye:
Iintsholongwane:I-COVID-19, umkhuhlane A & B,RSV,Adv,hMPV,Rhv,Parainfluenza iindidi I-IV, HBoV,EV,CoV
Intsholongwane:MP,Cpn,SP
-I-Lyophilized Reagents Zizinzile kuBubushushu beGumbi (2–30°C)
Yenza lula ukugcinwa kunye nokuthutha, ukuphelisa ukuxhomekeka kwikhonkco elibandayo.
Inkqubo yoThintelo loNgcoliseko oluqinileyo
Imilinganiselo ye-11 yokuchasana nokungcoliswa kwe-UV, ukuhluzwa kwe-HEPA, kunye nokuhamba kwe-cartridge evaliweyo, njl.
Ukulungelelaniswa kuzo zonke iiSetingi
Ilungele iilebhu zesibhedlele, amasebe kaxakeka, iiCDCs, iikliniki ezihambayo, kunye nemisebenzi yasendle.
Izisombululo ezinjalo zixhobisa oogqirha ngeziphumo ezikhawulezayo, ezithembekileyo ezinokukhokela izigqibo ngexesha elifanelekileyo kunye nolwazi.
I-hMPV yintsholongwane eqhelekileyo ene-impembelelo engaqhelekanga. Ukuqonda ukuba i-hMPV iya “ngaphaya kokubanda okuqhelekileyo” kubalulekile ekuphuculeni iziphumo zempilo yokuphefumla.
Ngokudibanisaukuqaphela okukhulu kweklinikhingeizixhobo zokuxilonga eziphambili, iinkqubo zokunakekelwa kwempilo zinokuchonga ngokuchanekileyo i-hMPV, ukwandisa ukhathalelo lwesigulane, kunye nokunciphisa umthwalo obalulekileyo kuwo onke amaqela eminyaka.
Ixesha lokuposa: Dec-08-2025