Iikhithi zokuQonda iiCarbapenemases zokuSika-uMda

I-CRE, eboniswe kunyeumngcipheko ophezulu wosulelo, ukufa okuphezulu, iindleko eziphezulu kunye nobunzimakunyango, kufunaukufunyanwa okukhawulezileyo, okusebenzayo nokuchanekileyoiindlela zokunceda ekuxilongweni nasekulawuleni isifo.

Ngokwe-Study of the top institutions and hospitals, iRapid Carbapenemases Detection Kit (Colloidal Gold) evela kwiMacro & Micro -Test, elingana ne-multi-qPCR assay, inika ukuchaneka okupheleleyo kwe-100% ekuchongeni i-carbapenemases kwi-bacterial isolates. Olu sebenzi lubalaseleyo ludlula iindlela zemveli ze-phenotypic ezifana ne-mCIM/eCIM kunye ne-CDT. Okubalulekileyo kukuba, uvavanyo lwe-colloidal gold lubonisa uvakalelo lwe-100%, ukucaca, ixabiso eliqikelelweyo elihle, kunye nexabiso elibi lokuqikelela kwi-carbapenemase nganye evavanyiweyo, nto leyo ebonisa ukusebenza kwayo okugqwesileyo nokungaguquguqukiyo ekuchongeni iintsholongwane ezivelisa i-carbapenemase.

Ukhetho 1:

NgokukhawulezaIsixhobo sokubona iiCarbapenemases (iColloidal Gold), inkqubela phambili entsha yokusombulula ingxaki engxamisekileyo ye-CRE esongela impilo yoluntu kwihlabathi liphela, kwiintsuku ezi-1-2 ngaphambi kwendlela yokuchaphazeleka ngamayeza;

 imizuzu eli-15ukuchonga i-NDM, i-KPC, i-OXA-48, i-IMP kunye ne-VIM kuphela kuvavanyo olunye;

 Utyando olulula ngolwelo lwe-blood culture ngaphandle kwe-plate culture, imizuzu eli-10 kuphela yokucoca nokuhlamba;

 Uvakalelo oluphezulu kunye nokungabikho kokusabela okudibeneyo kunye neentsholongwane eziqhelekileyo ezibangela izifo ezifana neKlebsiella pneumoniae, i-Acinetobacter baumannii, iPseudomonas aeruginosa okanye ezinye iisampulu ezivelisa i-β-lactamase;

 Ukusebenza ngokubanzi: Iimeko ezahlukeneyo kuquka izibhedlele, iikliniki, kunye namaziko empilo oluntu.

Ukhetho 2:

Ikhithi yokuFumanisa iGene yokuKhathazeka neCarbapenem (iFluorescence PCR), Uvavanyo lwe-6 kwi-1kunye nesiphumo ngaphakathiimizuzu engama-40, ichonga ngokuchanekileyoI-NDM, i-KPC, i-OXA23, i-OXA-48, i-IMP kunye ne-VIMkuvavanyo olunye;

 Ukusampula okulula: I-sputum, i-rectal swab okanye iikholoni ezicocekileyo;

 Ixabiso Elincitshisiweyo: Iithagethi ezi-6 ezifunyenwe kuvavanyo olunye ziphepha iimvavanyo ezingafunekiyo;

 Uvakalelo Oluphezulu kunye Nokuchaneka: 1000CFU/mL yovakalelo kunye nokungabikho kokudibana nezinye izifo zokuphefumla okanye iisampulu eziqulethe ezinye iijini ezinganyangekiyo ngamayeza i-CTX, i-mecA, i-SME, i-SHV, i-TEM, njl.njl.;

 Ukuhambelana okubanzi: Ngezixhobo zePCR eziphambili;