Impilo yokuzala ihamba kuwo wonke umjikelo wethu wobomi, othathwa njengenye yezalathi ezibalulekileyo zezempilo yabantu yi-WHO.Ngeli xesha, "impilo yokuzala kubo bonke" yamkelwa njengeNjongo yoPhuhliso oluZinzileyo ye-UN.Njengenxalenye ebalulekileyo yempilo yokuzala, ukusebenza kwenkqubo yokuzala, iinkqubo kunye nemisebenzi yenkxalabo kumntu ngamnye oyindoda.
01 Imingciphekoofizifo zokuzala
Usulelo lwendlela yokuzala sisoyikiso esikhulu kwimpilo yendoda yokuzala, ebangela ubudlolo malunga ne-15% yezigulane.Ibangelwa kakhulu yiChlamydia Trachomatis, Mycoplasma Genitalium kunye ne-Ureaplasma Urealyticum.Nangona kunjalo, malunga ne-50% yamadoda kunye ne-90% yabasetyhini abanosulelo lwe-reproductive tract ayikhathalelwanga okanye i-asymptomatic, ekhokelela kuthintelo kunye nolawulo losulelo lwe-pathogens aluhoywa.Ukuxilongwa kwangethuba nangempumelelo kwezi zifo ke ngoko kuluncedo kwimekobume yempilo entle yokuzala.
Usulelo lweChlamydia Trachomatis (CT)
I-Chlamydia trachomatis usulelo lwe-urogenital tract ingabangela i-urethritis, i-epididymitis, i-prostatitis, i-proctitis kunye nobudlolo emadodeni kwaye inokubangela i-cervicitis, i-urethritis, isifo sokudumba kwe-pelvic, i-adnexitis, kunye nokungazali kwabasetyhini.Kwangaxeshanye, usulelo lweChlamydia trachomatis kubasetyhini abakhulelweyo lunokukhokelela ekuqhawukeni kwangaphambi kwexesha kwenwebu, ukuzala umntwana ongasekhoyo, ukuphunza okuzenzekelayo, i-endometritis yasemva kokuqhomfa kunye nezinye izinto.Ukuba ayiphathwa ngokufanelekileyo kubasetyhini abakhulelweyo, inokudluliselwa ngokuthe nkqo kwiintsana ezisanda kuzalwa, ezibangela i-ophthalmia, i-nasopharyngitis kunye nenyumoniya.Usulelo olungapheliyo lwe-genitourinary Chlamydia trachomatis luthanda ukukhula lube zizifo, ezifana ne-cervical squamous cell carcinoma kunye ne-AIDS.
Usulelo lwe-Neisseria Gonorrhoeae (NG)
Iimpawu zeklinikhi ze-Neisseria gonorrhoeae usulelo lwe-urogenital tract yi-urethritis kunye ne-cervicitis, kwaye iimpawu zayo eziqhelekileyo ziyi-dysuria, ukuchama rhoqo, ukungxamiseka, i-dysuria, i-mucus okanye i-purulent discharge.Ukuba ayiphathwa ngexesha, i-gonococci ingangena kwi-urethra okanye isasazeke phezulu ukusuka emlonyeni wesibeleko, ibangele i-prostatitis, i-vesiculitis, i-epididymitis, i-endometritis, kunye ne-salpingitis.Kwiimeko ezinzima, kunokubangela i-gonococcal sepsis ngokusasazwa kwe-hematogenous.I-mucosal necrosis ebangela i-squamous epithelium okanye ukulungiswa kwezicubu ezidibeneyo kunokukhokelela kukuqina kwe-urethral, i-vas deferens kunye nokuncipha kwe-tubal okanye i-atresia kunye nokukhulelwa kwe-ectopic kunye nobudlolo kumadoda kunye nabasetyhini.
Usulelo lwe-Ureaplasma Urealyticum (UU)
I-Ureaplasma urealyticum idla ngokuba yi-parasitic kwi-urethra yendoda, kwijwabu lelungu lobudoda, kunye nelungu lobufazi.Inokubangela usulelo lomgudu womchamo kunye nobudlolo phantsi kweemeko ezithile.Isifo esiqhelekileyo esibangelwa yi-ureaplasma yi-nongonococcal urethritis, eyenza i-60% ye-nonbacterial urethritis.Isenokubangela i-prostatitis okanye i-epididymitis emadodeni, i-vaginitis kubasetyhini, i-cervicitis, ukuzalwa kwangaphambi kwexesha, ukuzalwa okuphantsi, kwaye kunokubangela usulelo lwenkqubo yokuphefumla kunye neyombindi ye-nervous yeentsana ezisanda kuzalwa.
Usulelo lweNtsholongwane yeSilaphu (HSV)
I-Herpes simplex virus, okanye i-herpes, ihlulwe ibe ngamacandelo amabini: i-herpes simplex virus type 1 kunye ne-herpes simplex virus type 2. I-Herpes simplex virus type 1 ibangela i-herpes yomlomo ikakhulu ngokuqhagamshelana nomlomo, kodwa inokubangela ukuba i-herpes yangasese.I-Herpes simplex virus uhlobo lwe-2 lusulelo oludluliselwa ngesondo olubangela i-herpes yangasese.I-herpes yangasese inokuphinda ibuye kwaye ibe nempembelelo enkulu kwimpilo yezigulane kunye nengqondo.Isenokosulela iintsana ezisandula ukuzalwa ngeplacenta kunye nomjelo wokubeleka, nto leyo ekhokelela kusulelo oluzalwa lusana olusanda kuzalwa.
I-Mycoplasma Genitalium Infection (MG)
I-Mycoplasma genitalium yeyona nto incinci eyaziwayo ikwazi ukuziphindaphinda i-genome ekwi-580kb kuphela kwaye ifumaneka ngokubanzi ebantwini nakwizilwanyana.Kubantu abancinci ababelana ngesondo, kukho ulungelelwaniso olomeleleyo phakathi kokungahambi kakuhle kwendlela ye-urogenital kunye ne-Mycoplasma genitalium, ukuya kuthi ga kwi-12% yezigulane ezineempawu ezibonisa ukuba zilungile kwi-Mycoplasma genitalium.Ngaphandle koko, i-pepole esulelwe yi-Mycoplasma Genitalium inokuphinda ikhule ibe yi-urethritis engekho-gonococcal kunye ne-prostatitis engapheliyo.Usulelo lwe-Mycoplasma genitalium yi-arhente ezimeleyo ye-causative yokuvuvukala komlomo wesibeleko kubasetyhini kwaye ihambelana ne-endometritis.
I-Mycoplasma Hominis Infection (MH)
Ukusuleleka kwe-Mycoplasma hominis ye-genitourinary tract kunokubangela izifo ezifana ne-non-gonococcal urethritis kunye ne-epididymitis kumadoda.Ibonakalisa njengokuvuvukala kwenkqubo yokuzala kwabasetyhini esasazeka ngokubhekisele kumlomo wesibeleko, kwaye i-comorbidity eqhelekileyo yi-salpingitis.I-Endometritis kunye nesifo sokuvuvukala kwe-pelvic sinokuvela kwinani elincinci lezigulane.
02Isisombululo
IMacro & Micro-Test iye yazibandakanya nzulu kuphuhliso lwentsholongwane ye-urogenital enxulumene nosulelo lwe-reagents yokubona izifo, kwaye iphuhlise izixhobo zokufumanisa ezinxulumene (i-Isothermal Amplification Detection method) ngolu hlobo lulandelayo:
03 Ukucaciswa kweMveliso
| Igama lemveliso | Inkcazo |
| Chlamydia Trachomatis Nucleic Acid Detection Kit (Enzymatic Probe Isothermal Amplification) | Iimvavanyo ezingama-20/ikhithi Iimvavanyo ezingama-50/ikhithi |
| IKit ye-Neisseria Gonorrhoeae Nucleic Acid Detection (Enzymatic Probe Isothermal Amplification) | Iimvavanyo ezingama-20/ikhithi Iimvavanyo ezingama-50/ikhithi |
| Ureaplasma Urealyticum Nucleic Acid Detection Kit(Enzymatic Probe Isothermal Amplification) | Iimvavanyo ezingama-20/ikhithi Iimvavanyo ezingama-50/ikhithi |
| I-Herpes Simplex Virus Type 2 Nucleic Acid Detection Kit (Enzymatic Probe Isothermal Amplification) | Iimvavanyo ezingama-20/ikhithi Iimvavanyo ezingama-50/ikhithi |
04 Aizinto eziluncedo
1. Ulawulo lwangaphakathi lungeniswa kule nkqubo, enokubeka iliso ngokubanzi inkqubo yovavanyo kunye nokuqinisekisa umgangatho wovavanyo.
2. Indlela yokubona i-Isothermal Amplification ixesha elifutshane lokuvavanya, kwaye umphumo unokufumaneka kwimizuzu engama-30.
3. Nge-Macro & Micro-Test Sample Release Reagent kunye ne-Macro & Micro-Test Automatic Nucleic Acid Extractor (HWTS-3006), kulula ukuyisebenzisa kwaye ifanelekile kwiimeko ezahlukeneyo.
4. Uvakalelo oluphezulu: i-LoD ye-CT yi-400copies / mL;i-LoD ye-NG yi-50 pcs / mL;i-LoD ye-UU yi-400copies/mL;i-LoD ye-HSV2 ngama-400 eekopi/mL.
5. Ukucaciswa okuphezulu: akukho-cross-reactivity kunye nezinye ii-arhente ezosulelayo ezinxulumene nazo (ezifana ne-syphilis, iintsumpa zangasese, i-chancroid chancre, i-trichomoniasis, i-hepatitis B kunye ne-AIDS).
IiReferensi:
[1] I-LOTTI F, i-MAGGI M. Ukungasebenzi ngokwesondo kunye nokungabikho komntwana [J] .NatRev Urol, 2018,15 (5): 287-307.
[2] CHOY JT,EISENBERG ML.Ukungachumi kwamadoda njengefestile kwimpilo[J].Fertil Steril,2018,110(5):810-814.
[3] ZHOU Z, ZHENG D, WU H, et al.I-Epidemiology yokungabikho komntwana e-China: uphononongo olusekelwe kuluntu [J] .BJOG, 2018,125 (4): 432-441.
Ixesha lokuposa: Nov-04-2022