Yintoni ebangela usulelo lwe-C. Diff?
Usulelo lwe-C.Diff lubangelwa yintsholongwane eyaziwa ngokuba yiI-Clostridioides difficile (C. difficile), ehlala ihlala ingenabungozi emathunjini. Nangona kunjalo, xa ibhalansi yebhaktheriya yamathumbu iphazamiseka, kudla ngokusetyenziswa amayeza okubulala iintsholongwane asebenzisa i-broad-spectrum, i-C. difficile inokukhula kakhulu kwaye ivelise iityhefu, nto leyo ekhokelela kusulelo.
Le ntsholongwane ikhona kuzo zombiniityhefukunye neefom ezingezizo ezibangela ubuthi, kodwa ziintlobo ze-toxigenic kuphela (iityhefu A kunye no-B) ezibangela isifo. Zibangela ukudumba ngokuphazamisa iiseli ze-epithelial zamathumbu. I-Toxin A ngokuyintloko yi-enterotoxin eyonakalisa ulwelo lwamathumbu, inyuse ukungena kwamanzi, kwaye itsale iiseli zomzimba ezikhupha ii-cytokines ezivuthayo. I-Toxin B, i-cytotoxin enamandla ngakumbi, ijolise kwi-actin cytoskeleton yeeseli, nto leyo ekhokelela ekujikelezeni kweeseli, ekuqhekekeni kwazo, kwaye ekugqibeleni ukufa kweeseli. Xa zidibene, ezi tyhefu zibangela umonakalo kwizicubu kunye nempendulo enamandla yomzimba, ebonakala njenge-colitis, urhudo, kwaye kwiimeko ezinzima, i-pseudomembranous colitis—ukudumba okukhulu kwekholoni.
Ingaba kwenzeka njaniC. Umahlukousasazeko?
I-C.Diff isasazeka lula. Ifumaneka ezibhedlele, ifumaneka rhoqo kwii-ICU, ezandleni zabasebenzi besibhedlele, kumgangatho wesibhedlele nakwiindawo zokubambelela, kwii-thermometers ze-elektroniki, nakwezinye izixhobo zonyango...
Izinto Ezibangela Umngcipheko Wosulelo lwe-C. Diff
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●Ukulaliswa esibhedlele ixesha elide; -
●Unyango lwe-antimicrobial; -
●Iiarhente zonyango lwe-chemotherapy; -
●Utyando lwakutshanje (iingalo zesisu, i-gastric bypass, utyando lwe-colon); -
●Isondlo sesisu esingaphakathi; -
●Usulelo lwe-C. diff lwangaphambili;
Iimpawu zosulelo lwe-C. Diff
Usulelo lwe-C. diff lunokuba lungathandeki kakhulu. Uninzi lwabantu luhlala lunesifo sorhudo kunye nokungonwabi esiswini. Iimpawu eziqhelekileyo zezi: isifo sorhudo, iintlungu zesisu, isicaphucaphu, ukungabi namdla wokutya, umkhuhlane.
Njengoko usulelo lwe-C. diff lusiba mandundu, kuya kubakho uphuhliso lohlobo oluntsonkothileyo lwe-C. diff olwaziwa ngokuba yi-colitis, i-pseudomembranous enteritis kunye nokufa.
Uxilongoyosulelo lwe-C. Diff
Inkcubeko yeBhaktheriya:Ibuthathaka kodwa ithatha ixesha elide (iintsuku ezi-2-5), ayikwazi ukwahlula iintlobo ze-toxigenic kunye ne-non-toxigenic;
Inkcubeko yeTyhefu:ichonga iintlobo zetyhefu ezibangela izifo kodwa zithatha ixesha elide (iintsuku ezi-3-5) kwaye azinabungozi kangako;
Ukufunyanwa kwe-GDH:ikhawuleza (iiyure ezili-1-2) kwaye ingabizi kakhulu, inobuthathaka kakhulu kodwa ayikwazi ukwahlula iintlobo ze-toxigenic kunye ne-non-toxigenic;
Uvavanyo lwe-Cell Cytotoxicity Neutralization Assay (CCNA):ifumanisa ityhefu A kunye ne-B ngobuthathaka obuphezulu kodwa ithatha ixesha (iintsuku ezi-2-3), kwaye ifuna izibonelelo ezikhethekileyo kunye nabasebenzi abaqeqeshiweyo;
Ityhefu A/B ELISA: Uvavanyo olulula nolukhawulezayo (iiyure ezi-1-2) olunovakalelo oluphantsi kunye neziphumo ezingezizo ezilungileyo rhoqo;
Uvavanyo lweNucleic Acid Amplification (ii-NAAT): Iyakhawuleza (1-3hrs) kwaye inovakalelo kakhulu kwaye icacile, ifumanisa iijini ezibangela ukuveliswa kwetyhefu;
Ukongeza, iimvavanyo zokujonga amathumbu, ezifana ne-CT scans kunye ne-X-ray, zingasetyenziswa ukunceda ekuxilongweni kwe-C. diff kunye neengxaki ze-C. diff, ezifana ne-colitis.
Unyango losulelo lwe-C. Diff
Kukho iindlela ezininzi zonyango ezikhoyoUsulelo lwe-C. diffNazi iindlela ezilungileyo:
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●Amayeza okubulala iintsholongwane asetyenziswa ngomlomo afana ne-vancomycin, i-metronidazole okanye i-fidaxomicin asetyenziswa rhoqo njengoko amayeza anokudlula kwinkqubo yokugaya ukutya aze afikelele kumathumbu amakhulu apho kuhlala khona iintsholongwane ze-C. diff. -
●I-metronidazole efakwa emithanjeni ingasetyenziselwa unyango ukuba usulelo lwe-C. diff lunzima. -
●Ukufakelwa kwe-microbiota yendle kubonakalise ukusebenza kakuhle ekunyangeni usulelo oluqhelekileyo lwe-C. diff kunye nosulelo olunzima lwe-C. diff olungaphenduliyo kwii-antibiotics. -
●Utyando lunokufuneka kwiimeko ezinzima.
Isisombululo sokuxilonga esivela kwi-MMT
Ukuphendula kwimfuneko yokufumanisa ngokukhawuleza nangokuchanekileyo i-C. difficile, sazisa i-Nucleic Acid Detection Kit yethu entsha ye-Clostridium difficile toxin A/B gene, sixhobisa iingcali zezempilo ukuba zenze uxilongo kwangethuba nangokuchanekileyo kunye nokuxhasa ukulwa nosulelo olufunyenwe esibhedlele.
●Uvakalelo oluphezulu: Ifumanisa ukuba isezantsi njenge200 CFU/mL,;
●Ukujolisa ngokuchanekileyo: Ichaza ngokuchanekileyo i-C. difficile toxin A/B gene, inciphisa iziphumo ezingezizo ezilungileyo;
●Ukufunyanwa kwePathogen ngokuthe ngqo: Isebenzisa uvavanyo lwe-nucleic acid ukuchonga ngokuthe ngqo ii-toxin genes, imisela umgangatho obalaseleyo wokuxilongwa.
●Ihambelana ngokupheleleyo neizixhobo ze-PCR eziphambili ezijongana neelabhoratri ezininzi;
Umzekelo-wempenduloIsisombululo kwi-Macro & Micro-Test's AIO800 Mobile PCR Lab
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●Ukuziqhelanisa kweSampuli-ukuya-kwimpendulo – Layisha iityhubhu zesampulu zokuqala (1.5–12 mL) ngokuthe ngqo, ukuphelisa ukutsalwa kwepayipi ngesandla. Ukukhupha, ukwandisa, kunye nokubhaqwa kuzenzekelayo ngokupheleleyo, kunciphisa ixesha lokusebenza kunye neempazamo zomntu. -
●Ukhuseleko Lokungcola OluneZintlu Ezisibhozo – Ukuhamba komoya kwicala, uxinzelelo olubi, ukuhluzwa kwe-HEPA, ukubulala iintsholongwane kwi-UV, ukusabela okuvaliweyo, kunye nezinye iindlela zokukhusela ezidibeneyo zikhusela abasebenzi kwaye ziqinisekisa iziphumo ezithembekileyo ngexesha lovavanyo oluphezulu.
Ukuze ufumane iinkcukacha ezithe vetshe:
https://www.mmtest.com/nucleic-acid-detection-kit-for-clostridium-difficile-toxin-ab-gene-fluorescence-pcr-product/
Contact us to learn more: marketing@mmtest.com;
Ixesha lokuthumela: Agasti-12-2025