Ingozi Yehlabathi Lonke Iyakhawuleza
Ingxelo entsha ye-World Health Organisation (WHO), i-Global Antibiotic Resistance Surveillance Report 2025, inika isilumkiso esiqatha: ukunyuka kokuxhathisa iintsholongwane (AMR) kudlula amandla ethu okulwa nako. Phakathi kowama-2018 nowama-2023, ukuxhathisa kwanda ngaphezu konyaka.40%ukubekwa esweni kweendibaniselwano ze-pathogen-antibiotic, kunye nokunyuka okuqhelekileyo konyaka5-15%.
Umthwalo awuhlanganyelwa ngokulinganayo. Ingxelo iqikelela ukuba ukumelana neentsholongwane kuphezulu kakhulu kwi-WHO South-East Asia kunye neMpuma Mediterranean Regions, apho kukho inani elimangalisayo.1 kwaba-3Iingxelo zokuba izifo azizange zikwazi ukumelana nazo. Le ngxaki ikhula ngokukhula isongela ukuphazamisa amayeza anamhlanje, nto leyo eyenza ukuba izifo eziqhelekileyo ziphinde zibe yingozi ebomini kwaye zibeke emngciphekweni impumelelo yotyando, i-chemotherapy, kunye nezinye iinkqubo ezibalulekileyo.
Umsantsa Wokuxilonga kwiMfazwe ye-AMR
UMlawuli-Jikelele we-WHO, uGqr. Tedros Adhanom Ghebreyesus, ugxininise ukuba ukulwa ne-AMR kufuna ukuqinisa ukubekwa esweni nokuqinisekisa ukufikelela kumayeza afanelekileyo kunye nokuxilongwa. Umqobo obalulekileyo kule mpi lixesha elithathwayo ukuchonga ngokuchanekileyo iintsholongwane ezinganyangekiyo. Iindlela zemveli zingathatha iintsuku, zinyanzelise oogqirha ukuba banike amayeza okubulala iintsholongwane asebenzisa i-wide-spectrum antibiotics ngokweemvavanyo—into ekhuthaza umjikelo wokunganyangeki.
Kulapho ke ukuxilongwa okusemgangathweni kulungele ukutshintsha umdlalo. Ngokubonelela ngokuchongwa ngokukhawuleza nangokuchanekileyo kweendlela zokuxhathisa, banika amandla ababoneleli beenkonzo zempilo ukuba benze izigqibo ezinolwazi nezisindisa ubomi ngoko nangoko.
Uvavanyo lweMacro kunye nolweMicro's Izisombululo: Ukuxilongwa ngokuchanekileyo kokulwa nengxaki ye-AMR
Ukuphendula ngokuthe ngqo kwimingeni echazwe yi-WHO, sinikezela ngezisombululo ezimbini ezidityanisiweyo zokuxilonga ezenzelwe ukubonelela ngesantya, ukuchaneka, kunye nokuguquguquka okufunekayo ukukhusela izigulana kunye nokukhusela iinkqubo zempilo.
Isisombululo 1: Iqinisekiswe yi-CENgokukhawulezaIkhithi yokuFumanisa iCarbapenemase
-Isantya kunye nokuchaneka okungenakuthelekiswa nanto:Le khithi ingenazo izixhobo ifumana ii-genes ezintlanu eziphambili ze-carbapenemase (i-KPC, i-NDM, i-OXA-48, i-VIM, i-IMP)—ezigubungela ngaphezulu kwe-95% yeendidi ezahlukeneyo zeklinikhi ezaziwayo—kwixesha nje elifutshane.imizuzu eli-15. Ngobuchule obungaphezulu kwama-95%, inika iziphumo ezithembekileyo kakhulu ngexesha elifunekayo, iguqula ixesha lokulinda libe lixesha lesenzo esibalulekileyo.
-Izikhokelo Unyango Olujoliswe Ngokukhawuleza:Le khithi iguqula ulawulo lwezonyango ngokuhambisa idatha esebenzayo ngoko nangoko. Oku kwenza ukuba oogqirha bakwazi ukuqalisa unyango olusebenzayo lokubulala iintsholongwane ngoko nangoko, nto leyo ephucula kakhulu iziphumo zezigulana ezisengozini enkulu kwi-ICU, kwi-oncology, nakwiiwadi zotyando.
-Ikhusela iinkqubo zempilo:Isebenza njengesixhobo esibalulekileyo kwiinkqubo zokulawula usulelo kunye nokugcinwa kweentsholongwane. Ukukhawuleza kwayo kubalulekile ekuthinteleni ukuqhambuka kwezifo kwiindawo ezinobungozi obukhulu, kunceda ekunciphiseni ukuhlala esibhedlele kunye neendleko ezinxulumene noko, ngaloo ndlela kukhusela izixhobo zesikhungo.
Isisombululo sesi-2: Amandla adibeneyo e-AIO800 +IimolekyuliIkhithi ye-CRE
I-Molecular POCT yeSampuli-ukuya-Kwimpendulo inika isisombululo esipheleleyo nesichanekileyo.
-Ukufunyanwa kweMultiplex epheleleyo:Esi sisombululo sichazaii-genes ezintandathu eziphambili ze-carbapenemase (i-KPC, i-NDM, i-OXA-48, i-OXA-23, i-VIM, i-IMP)kuvavanyo olunye. Olu gubungela ngokubanzi lwenza kube lula ukuhamba komsebenzi, lunciphisa isidingo sovavanyo oluninzi, kwaye lunciphisa kakhulu iindleko zokuxilonga.
- Uvakalelo oluphezulu kunye nokuChaneka:Yenzelwe ukuchaneka okugqwesileyo, ikhithi ibona ngaphantsi kwe1,000 CFU/mLngaphandle kokwenza izinto ezahlukeneyo, okuqinisekisa ukuxilongwa okuthembekileyo nokuba kwiisampuli ezintsonkothileyo, ezineentsholongwane ezininzi.
-Ubuninzi bokuguquguquka kwePlatform:Yenzelwe ukusetyenziswa ngokubanzi, le khithi iyahambelana nazo zombini izixhobo ezizenzekelayo neziphezuluInkqubo ye-AIO800kunye nezixhobo zePCR eziqhelekileyo.
Inkqubo ye-AIO800 ichaza kwakhona ukusebenza kakuhle ngoyilo lwayo oluhlanganisiweyo ngokupheleleyo, inika iziphumo kwimizuzu engama-76 kuphela ngelixa ibandakanya inkqubo yokhuseleko enamaleko ali-11 ukunciphisa iingozi zongcoliseko.
Ukuguqula iXesha Ngobulumko Obufike Ngexesha Elifanelekileyo
Idatha yamva nje ye-WHO icacisa ukuba i-AMR ayisosisongelo sexesha elizayo kodwa yingozi ekhoyo nekhulayo. Indlela eya phambili ifuna indlela eneenkcukacha ezininzi apho ukuxilongwa okuphambili kudlala indima ebalulekileyo. Izisombululo zethu zibonelela "ngobulumko obufike ngexesha" obufunekayo ukuze uhlale uphambili kwiintsholongwane ezinganyangekiyo, kuvumela unyango olujoliswe kulo, ukulawula ukuqhambuka, kunye nokugcina imigangatho yolawulo lwe-antibiotics kwihlabathi liphela.
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Ixesha leposi: Jan-19-2026