Ulawulo Oluchanekileyo lwe-CML: Indima Ebalulekileyo Yokuchongwa kwe-BCR-ABL Kwixesha le-TKI

Ulawulo lwe-Chronic Myelogenous Leukemia (CML) luye lwaguqulwa yiTyrosine Kinase Inhibitors (TKIs), iguqula isifo esibulalayo sibe yimeko engapheliyo elawulekayo. Intliziyo yale bali yempumelelo kukho ukubekwa esweni ngokuchanekileyo nangokuthembekileyo kwesifo.I-BCR-ABL fusion gene—umqhubi weemolekyuli oqinisekileyo we-CML.

Ngaphandle kokuxilongwa kokuqala, ukulinganiswa kwe-BCR-ABL sisiseko solawulo olusebenzayo noluhlala luhleli lwezigulane. Inika oogqirha idatha ebalulekileyo efunekayo ukuze:

Misela isisekoxa uxilongwa.

Vavanya Impendulo Yonyango Kwangokokwaye baqikelele iziphumo zexesha elide.

Isikhokelo soLungiso lweTKI Therapyngokusekelwe kwiindlela ezibalulekileyo zokuphendula kwiimolekyuli.

Ukubeka esweni isifo esincinci esisele (MRD)kunye nokubuyela umva okunokwenzeka.

Nangona kunjalo,Ukufunyanwa okungathembekanga kunokuphazamisana nezi zigqibo.

Uvavanyo lweMacro kunye nolweMicro's Ikhithi yokuFumana utshintsho lwe-Human BCR-ABL Fusion Gene Mutationyenzelwe ukubonelela ngokuchanekileyo okufunekayo ukuze kuqinisekiswe kuzo zonke izigaba.

Kutheni Isisombululo Sethu Siliqabane Elithembekileyo kwi-CML Care:

1. Iprofayili Epheleleyo:Ifumana iitranscript ezintathu eziphambili ze-BCR-ABL (P210, P190, P230) ngaxeshanye, iqinisekisa ukuba akukho tyala libalulekileyo liphoswayo.
2. Uvakalelo olungenakuthelekiswa nanto:Ifikelela kumda wokufumanisa (i-LoD) ophantsi njenge1,000 iikopi/mL, okuvumela uvavanyo lwangethuba noluchanekileyo lweempendulo ezinzulu zeemolekyuli.
3. Ukuchaneka Okungqongqo:Ibandakanya ulawulo lwangaphakathi kunye nenkqubo ye-enzyme ye-UNG ukususa izinto ezilungileyo/ezingalunganga ezingezizo ezilungileyo, ikhusela ukuthembeka kweziphumo.
4. Ukuhamba komsebenzi okucwangcisiweyo:Isebenza ngetyhubhu evaliweyo, ngaphandle kwe-PCR, inika iziphumo ezichanekileyo ngaphantsi kwemizuzu engama-60 ukukhawulezisa ukwenziwa kwezigqibo zonyango.
5. Ukuguquguquka kokusebenza:Ifumaneka kwiifomathi ezingamanzi kunye ne-lyophilized ukuze ivumelane nokukhethwa kwelabhoratri okwahlukeneyo.
   
   Yamkela umgangatho wegolide wokubeka esweni iimolekyuli. Xhobisa ikliniki yakho ngokuchanekileyo okufunekayo ukuze ulungiselele ukhathalelo lobomi bonke lwezigulane zakho ze-CML.

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