Ulawulo oluchanekileyo lwe-CML: Indima ebalulekileyo ye-BCR-ABL yokuFumana kwi-TKI Era

Ulawulo lwe-Chronic Myelogenous Leukemia (CML) luye lwatshintshwa yiTyrosine Kinase Inhibitors (TKIs), ukuguqula isifo esibulalayo sibe yimeko engapheliyo. Embindini weli bali lempumelelo kulele iliso elichanekileyo nelithembekileyoI-BCR-ABL yemfuza yokudibanisa-umqhubi we-molecular ocacileyo we-CML.

Ngaphandle kokuxilongwa kokuqala, ubungakanani be-BCR-ABL sisiseko solawulo olusebenzayo, ubomi besigulane. Ibonelela oogqirha ngedatha ebalulekileyo efunekayo:

Misela isisekoekuxilongeni.

Vavanya iMpendulo yoNyango kwangethubakunye nokuqikelela iziphumo zexesha elide.

Isikhokelo soLungiso loNyango lwe-TKIisekelwe kwimilinganiselo yempendulo yeemolekyuli.

Ukubeka iliso kwiSifo esiNcinane esiSasalelayo (MRD)kunye nokubuyela umva kwakhona.

Nangona kunjalo,Ukufunyaniswa okungathembekanga kunokubeka esichengeni ezi zigqibo.

Uvavanyo olukhulu kunye novavanyo oluncinci's I-BCR-ABL yoMntu ye-Fusion Gene Mutation yeKit yokubonayenzelwe ukuzisa ukuchaneka okufunekayo kukuzithemba kwinqanaba ngalinye.

Kutheni isisombululo sethu siliqabane elithembekileyo kukhathalelo lwe-CML:

1. Iprofayile eBanzi:Ngaxeshanye ibona imibhalo emithathu emikhulu ye-BCR-ABL (P210, P190, P230), iqinisekisa ukuba akukho meko ibalulekileyo ephosiweyo.
2. Uvakalelo olungahambelaniyo:Iphumeza umda wokubhaqa (LoD) ngokuphantsi njenge1,0Iikopi ze-00 / mL, eyenza uvavanyo lwakwangoko kunye noluchanekileyo lweempendulo ezinzulu zeemolekyuli.
3. Ukuchaneka okungqongqo:Ibandakanya ulawulo lwangaphakathi kunye nenkqubo ye-enzyme ye-UNG ukuphelisa izinto ezingalunganga / ezingalunganga, ukukhusela ingqibelelo yesiphumo.
4. Ukuqhutywa komsebenzi oLungelweyo:Iquka i-tube evaliweyo, i-post-PCR-free operation, ukuhambisa iziphumo zenjongo phantsi kwemizuzu engama-60 ukukhawulezisa ukwenza izigqibo zeklinikhi.
5. Ukusebenza bhetyebhetye:Inikezelwa ngolwelo kunye neefomathi ze-lyophilized ukuze zihambelane nokukhethwa kwelebhu ezahlukeneyo.
   
   Yamkela umgangatho wegolide kuhlolo lwemolekyuli. Xhobisa ikliniki yakho ngokuchaneka okufunekayo ukuze ukwandise ukhathalelo lobomi bonke kwizigulana zakho ze-CML.

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