Uphononongo lweIPhepha loPhando lweClassic
iRespiratory Syncytial Virus (RSV) kunye neHuman Metapneumovirus (HMPV) tYeha iintsholongwane ezinxulumene ngokusondeleyo ngaphakathiPneumoviridaeusaphoabasoloko bebhideka kwiimeko zosulelo lwabantwana olubukhali lokuphefumla. Ngelixa iinkcazo zabo zeklinikhi zidibana, idatha yokucupha (2016-2020) evela kwizibhedlele zabantwana ze-7 zase-US-ezibandakanya izigulane ze-8,605-zibonisa umahluko obalulekileyo kubantu abasengozini enkulu, ubunzima besifo, kunye nolawulo lweklinikhi. Olu phononongo lusebenzise uyilo olusebenzayo, olulindelekileyo kunye nokuqokelela okucwangcisiweyo kwe-nasopharyngeal swab kunye nokuvavanya iintsholongwane ezi-8 zokuphefumla, ukubonelela ngomlinganiselo wokuqala omkhulu, uthelekiso lwehlabathi lokwenyani koogqirha babantwana. Ngokuhlalutya amazinga okulaliswa esibhedlele, ukulaliswa kwe-ICU, ukusetyenziswa komatshini wokungena komoya, kunye nokuhlala ixesha elide esibhedlele (≥iintsuku ezi-3), kuseka isiseko esibalulekileyo se-epidemiological pre-intervention kwixesha logonyo olutsha lwe-RSV (umz., izitofu zokugonya komama, izithinteli-ntsholongwane ze-monoclonal ezithatha ixesha elide) kunye nokudala isakhelo sophuhliso lwe-HMP yekamva.
Ukufumana okungundoqo 1: IiProfayili ezicacileyo zoMngcipheko oMkhulu
-I-RSV ichaphazela ikakhulu iintsana ezincinci:Ubudala obuphakathi bokulaliswa esibhedlele yayiziinyanga ezi-7 kuphela, kunye ne-29.2% yezigulane ezivunyiweyo ziintsana (iinyanga ezi-0-2). I-RSV ngoyena nobangela uphambili wokulaliswa esibhedlele kwiintsana ezingaphantsi kweenyanga ezi-6, ngobukhali obuhambelana nobudala.
-I-HMPV ijolise kubantwana abadala kunye nabo banezigulo:Ubudala obuphakathi bokulaliswa esibhedlele yayiziinyanga ezili-16, kunye nempembelelo enkulu kubantwana abangaphezu konyaka omnye. Ngokucacileyo, ukuxhaphaka kweemeko zonyango eziphantsi (umz., i-cardiovascular, neurological, breathing) yayingaphezu kokuphindwe kabini kwizigulane ze-HMPV (26%) xa kuthelekiswa nezigulane ze-RSV (11%), zigxininisa ubuthathaka babo obuphezulu.
Umzobo 1. Ukuhanjiswa kweminyaka yobudala bokutyelelwa kwe-ED kunye nezibhedleleezinxulumene ne-RSV okanye i-HMPV
kubantwana abangaphantsi kweminyaka eyi-18.
Ukufumana okuPhambili kwesi-2: Ukwahlula iiNkcazo zeklinikhi
-I-RSV ibonakalisa ngeempawu ezibalaseleyo zokuphefumla ezisezantsi:Inxulumene kakhulu ne-bronchiolitis (i-76.7% yamatyala esibhedlele). Iimpawu eziphambili zibandakanyaukubuyisela udonga lwesifuba (76.9% izigulane; 27.5% ED)kwayetachypnea (91.8% izigulane; 69.8% ED), zombini ngokuphawulekayo rhoqo ngakumbi kune-HMPV.
-I-HMPV ibonakalisa umkhuhlane ophezulu kunye nomngcipheko we-pneumonia:I-Pneumonia yafunyaniswa kwi-35.6% yezigulane ze-HMPV ezibhedlele-ziphindwe kabini izinga le-RSV.Umkhuhlane yayiyeyona nto iphambili (83.6% yezigulane ezilaliswayo; 81% ED). Ngelixa iimpawu zokuphefumula ezifana nokuphefumla kunye ne-tachypnea zenzeka, ngokuqhelekileyo zincinci kakhulu kune-RSV.
Umfanekiso wesi-2.Iimpawu zokuthelekisa kunye neklinikhikunjaloye-RSV vs. HMPV kubantwana abangaphantsi kwe-18.
Isishwankathelo: RSVIkakhulu ibangela izifo ezimandla kwiintsana ezincinci, ezibonakaliswa kukuphefumla okukhulu (ukuphefumla, ukurhoxa) kunye ne-bronchiolitis.HMPVixhaphake kakhulu kubantwana abadadlana abanezigulo, iveza ifiva echaziweyo, inomngcipheko ophezulu wenyumoniya, kwaye isoloko ibangela ukudumba okubanzi kwenkqubo.
Ukufumana okungundoqo 3: Iipateni zoNyaka zibalulekile
-I-RSV inencopho yokuqala, eqikelelwayo:Umsebenzi wayo ugxininise kakhulu, uhlala ucotha phakathiNgoNovemba noJanuwari, okwenza kube yingozi enkulu yentsholongwane kwiintsana ekwindla nasebusika.
-Incopho ye-HMPV kamva inomahluko omkhulu:Ixesha layo lifika kamva, lidla ngokufika phezuluNgoMatshi nangoAprili, kwaye ibonisa ukuhluka okuphawulekayo konyaka nonyaka kunye nommandla, ngokuphindaphindiweyo kubonakala njenge "wave wesibini" emva kokuba i-RSV iyancipha.
Umfanekiso wesi-3.Lilonke kunye nesayithi-i-PCR elungileyoeiireyithi ze-RSV kunye ne-HMPV phakathi kwabantwana abangaphantsi kwe-18 abane-acute breathing infection (ARI)-ehambelana nokutyelelwa kwe-ED kunye nokulaliswa esibhedlele.
UThintelo noKhathalelo: Isicwangciso sokuSebenza esiSekwe kubungqina
-I-RSV Prophylaxis:Amacebo okuthintela ayafumaneka ngoku. Ngo-2023, i-US FDA yavuma i-anti-monoclonal antibody (i-Nirsevimab) yexesha elide, enokukhusela iintsana kwiinyanga zabo zokuqala ezi-5. Ukongeza, ugonyo lwe-RSV lomama ludlulisela ngempumelelo izilwa-buhlungu ezikhuselayo kubantwana abasanda kuzalwa.
-I-HMPV Prophylaxis:Okwangoku akukho machiza avunyiweyo othintelo. Nangona kunjalo, abaviwa abaninzi bogonyo (umzekelo, isitofu sokugonya se-RSV/HMPV esidityanisiweyo se-AstraZeneca) bakulingo lwezonyango. Abazali bayacetyiswa ukuba bahlale benolwazi malunga nohlaziyo oluvela kwabasemagunyeni kwezempilo yoluntu.
Funa iNgqwalasela yezoNyango eNgxamisekileyo kuyo nayiphi na kwezi "Flegi ziBomvu":
-Umkhuhlane kwiintsana:Ubushushu ≥38°C (100.4°F) kulo naluphi na usana olungaphantsi kweenyanga ezi-3 ubudala.
-Iqondo elinyusiweyo lokuphefumla:Ukuphefumula kudlula ukuphefumula kwe-60 ngomzuzu kwiintsana kwiinyanga ezi-1-5, okanye ukuphefumula kwe-40 ngomzuzu kubantwana abaneminyaka eyi-1-5, ebonisa ukuphefumla okunokwenzeka.
-Ukugcwala kweoksijini ephantsi:I-Oxygen saturation (SpO₂) iwela ngaphantsi kwe-90%, uphawu olubalulekileyo lwesifo esibi esibonwa kwi-30% ye-RSV kunye ne-32.1% yeemeko zesibhedlele se-HMPV kwisifundo.
-Ukutyhafa okanye ubunzima bokutyisa:Ukutyhafa okuphawulekayo okanye ukucutheka kokusela ubisi ngaphezu kwesinye esithathwini kwiiyure ezingama-24, nto leyo enokuba ngumanduleli wokuphelelwa ngamanzi emzimbeni.
Ngelixa uhlukeneyo kwi-epidemiology kunye nenkcazo yeklinikhi, ukwahlula ngokuchanekileyo phakathi kwe-RSV kunye ne-HMPV kwindawo yokunyamekela kuhlala kunzima. Ngaphaya koko, isoyikiso seklinikhi sidlulela ngaphaya kwezi ntsholongwane zimbini, kunye neepathogens ezinjengomkhuhlane A kunye ne-spectrum yezinye iipathogen zentsholongwane kunye neebhaktiriya ngaxeshanye zisongela impilo yabantu. Ukuxilongwa ngexesha kunye nokuchaneka kwe-etiological ke ngoko kubalulekile kulawulo olululo lwenkxaso, ukubekwa wedwa okusebenzayo, kunye nokwabiwa kwezibonelelo ezinengqondo.
Ukwazisa i-AIO800 + 14-Pathogen Combined Detection Kit (Fluorescence PCR)(NMPA, CE, FDA, SFDA ivunyiwe)
Ukuhlangabezana nale mfuno, iI-Eudemon™ AIO800 Inkqubo yokuFumana iNucleic Acid eZimeleyo ngokupheleleyo, idityaniswe neIphaneli yokuphefumula ye-14-pathogen, inikeza isisombululo sokuguqula - ukuhambisa inyaniso"isampulu ngaphakathi, phendula"diagnostics kwimizuzu nje 30.
Olu vavanyo lubanzi lokuphefumla lubhaqas zombini iintsholongwane kunye neebhaktheriyaukusuka kwisampulu enye, eyenza ababoneleli bezempilo bangaphambili ukuba benze izigqibo zokuzithemba, ngexesha, kunye nezijoliswe kuzo.
Iimpawu eziphambili zeNkqubo eziBalulekileyo kubaxumi bakho
Ukuhamba komsebenzi okuSebenzayo ngokupheleleyo
Ngaphantsi kwemizuzu emi-5 yezandla ngexesha. Akukho mfuneko yabasebenzi abanezakhono kwiimolekyuli.
- Iziphumo ezikhawulezayo
Ixesha lokuguqula imizuzu ye-30 lixhasa izicwangciso zeklinikhi ezingxamisekileyo.
- 14Ukufunyanwa kwePathogen Multiplex
Ukuchongwa ngaxeshanye:
Iintsholongwane:I-COVID-19, umkhuhlane A & B,RSV,Adv,hMPV,Rhv,Parainfluenza iindidi I-IV, HBoV,EV,CoV
Intsholongwane:MP,Cpn,SP
-I-Lyophilized Reagents Zizinzile kuBubushushu beGumbi (2–30°C)
Yenza lula ukugcinwa kunye nokuthutha, ukuphelisa ukuxhomekeka kwikhonkco elibandayo.
Inkqubo yoThintelo loNgcoliseko oluqinileyo
Imilinganiselo ye-11 yokuchasana nokungcoliswa kwe-UV, ukuhluzwa kwe-HEPA, kunye nokuhamba kwe-cartridge evaliweyo, njl.
Ukuchongwa okukhawulezayo, okubanzi kwe-pathogen kusisiseko kulawulo lwangoku losulelo lwabantwana lokuphefumla. Inkqubo ye-AIO800, ene-automated ngokupheleleyo, i-30-minute, ipaneli ye-PCR ye-multiplex, inika isisombululo esisebenzayo sezicwangciso zangaphambili. Ngokuvumela ukufunyanwa kwangaphambili kunye nokuchanekileyo kwe-RSV, i-HMPV, kunye nezinye iintsholongwane eziphambili, ixhobisa oogqirha ukuba benze izigqibo zonyango ezijoliswe kuzo, ukunyusa ukusetyenziswa kwe-antibiotics, kunye nokuphumeza ukulawulwa kokusuleleka okusebenzayo-ekugqibeleni kuphuculwe ukunakekelwa kwesigulane kunye nokusebenza kakuhle kwezempilo.
#RSV #HMPV #Ngokukhawuleza #Isazisi #Ukuphefumla #Pathogen # Isampuli-ukuphendula#MacroMicroTest
Ixesha lokuposa: Dec-02-2025