Ukufunyanwa ngaxeshanye kwesifo sephepha kunye ne-MDR-TB

Isifo sephepha (TB), esibangelwa yiMycobacterium tuberculosis(MTB), isengumngcipheko wezempilo kwihlabathi liphelakunye nokwandaukumelana nesitshixoTBiziyobisi ezifana neRifampicinn (RIF) kunye ne-Isoniazid (INH)kubaluleke kakhulu njengokoumqobo kwihlabathi liphelaTB imizamo yokulawula.Ikhawuleza kwaye ichanekileuvavanyo lwemolekyuliyesifo sephepha kunye nokunganyamezelani ne-RIF&I-INH icetyiswa yi-WHO ukubachongaizigulana ezineentsholongwanengexesha elifanelekileyokwayebanike unyango olufanelekileyo ngexesha elifanelekileyo.

Imingeni

Kuqikelelwa ukuba abantu abayi-10.6 yezigidiwagula sisifo sephepha ngo-2022, nto leyo ebangela ukubakuqikelelwa ukuba bangama-1.3 ezigidi abantu ababhubhileyo, kude kakhulu nomlinganiselo obalulekileyo ka-2025 weQhinga lokuPhelisa iTB

I-TB enganyangekiyo ngamayeza, ingakumbi i-MDR-TB (enganyangekiyo yi-RIF)&INH),ichaphazela ngakumbi ihlabathi TB unyangokunye nokuthintela.

Ukuxilongwa ngokukhawuleza ngaxeshanye kwe-TB kunye ne-RIF/INH ukumelana nayokufuneka ngokukhawulezangaphambilikwayeunyango olusebenza ngakumbi xa kuthelekiswakunyeiziphumo zovavanyo lokuchaphazeleka lula kweziyobisi zilibazisekile.

ZethuIsisombululo

UMarco kunye novavanyo oluncinciIsixhobo sokufumanisa i-TB esi-3 kwi-1 sosulelo lwe-TB/i-RIF kunye ne-NIH Resistance Detection Kitkwenza ukuba kuchongwe ngempumeleloI-TB kunye ne-RIF/INH ekufumaneni kanye.

Itekhnoloji yokunyibilikisa ijika ifumanisa ngaxeshanye iTB kunye neMDR-TB.

Ukufunyanwa kwe-3-in-1 TB/MDR-TB okufumanisa usulelo lwe-TB kunye nokuxhathisa amayeza aphambili odidi lokuqala (RIF/INH) kwenza ukuba unyango lwe-TB lufike ngexesha kwaye luchaneke.

I-Mycobacterium Tuberculosis Nucleic Acid kunye neRifampicin, iKit yokuFumanisa ukuKhawuleza kwe-Isoniazid (iMelting Curve)

Ufezekisa ngempumelelo uvavanyo lwe-TB oluphindwe kathathu (usulelo lwe-TB, i-RIF kunye ne-NIH Resistance) ngexesha elinye lokufumanisa!

Isiphumo esikhawulezayo: Ifumaneka kwiiyure ezi-2-2.5 kunye nokutolikwa kweziphumo ngokuzenzekelayo okunciphisa uqeqesho lobugcisa lokusebenza;

Isampuli yoVavanyo: isikhwehlela, inkcubeko eqinileyo, inkcubeko engamanzi

Uvakalelo oluphezulu: Iibhaktheriya ezingama-25/mL zeTB, iibhaktheriya ezingama-200/mL zebhaktheriya ezimelana ne-RIF, iibhaktheriya ezingama-400/mL zebhaktheriya ezimelana ne-INH, ukuqinisekisa ukufunyanwa okuthembekileyo nokuba imithwalo yebhaktheriya iphantsi.

Iithagethi ezininzi: I-TB-IS6110; I-RIF-resistance-rpoB (507~503); I-INH-resistance-InhA, AhpC, katG 315;

Ukuqinisekiswa koMgangatho: Ulawulo lwangaphakathi lokuqinisekisa umgangatho wesampulu ukunciphisa izinto ezingalunganga;

Ukuhambelana Okubanziy: Ukuhambelana neenkqubo ezininzi ze-PCR eziphambili ukuze kufikeleleke kwiilebhu ezininzi (i-Bio-Rad CFX96, i-SLAN-96P/96S, i-Bioer Quantgene 9600);

Ukuthotyelwa kweMigaqo ye-WHO: Ukunamathela kwizikhokelo ze-WHO zolawulo lwesifo sephepha esinganyangekiyo ngamayeza, ukuqinisekisa ukuthembeka nokufaneleka kwindlela yokusebenza kwezonyango.