Ukufunyanwa ngaxeshanye kwesifo sephepha kunye nokunganyamezelani ne-RIF kunye ne-NIH

Isifo sephepha (TB), esibangelwa yiMycobacterium tuberculosis, sisengumngcipheko kwimpilo yehlabathi. Kwaye ukwanda kokunganyangeki kwamayeza aphambili esifo sephepha afana neRifampicin (RIF) kunye neIsoniazid (INH) kubalulekile kwaye kungumqobo omkhulu kwimizamo yolawulo lwesifo sephepha kwihlabathi liphela. Uvavanyo lwe-molecular lwesifo sephepha olukhawulezileyo noluchanekileyo kunye nokunganyangeki kwiRIF & INH luyacetyiswa yi-WHO ukuze ichonge izigulane ezinentsholongwane ngexesha elifanelekileyo kwaye ibanike unyango olufanelekileyo ngexesha elifanelekileyo.

Imingeni

Kuqikelelwa ukuba abantu abazizigidi ezili-10.6 bagula yiTB ngo-2021, nto leyo ebangele ukwanda kwe-4.5% ukusuka kwi-10.1 yezigidi ngo-2020, nto leyo ebangele ukufa kwabantu abaqikelelwa kwi-1.3 yezigidi, okulingana ne-133 kwi-100,000 nganye.

I-TB engamelani namayeza, ingakumbi i-MDR-TB (engamelani ne-RIF kunye ne-INH), ichaphazela ngakumbi unyango kunye nothintelo lwe-TB kwihlabathi liphela.

Ukuxilongwa ngokukhawuleza ngaxeshanye kwe-TB kunye ne-RIF/INH ukumelana nonyango kufuneka ngokukhawuleza ukuze kufumaneke unyango lwangethuba nolusebenzayo xa kuthelekiswa neziphumo zovavanyo lokuchaphazeleka kukusetyenziswa kweziyobisi ezilibazisekileyo.

Isisombululo Sethu

Ukufunyanwa kwe-TB ye-3-in-1 kaMarco kunye neMicro-Test yosulelo lwe-TB/RIF kunye ne-NIH Resistance Detection Kityenza kube lula ukufumanisa isifo se-TB kunye ne-RIF/INH ngokukuko xa kuchongwa kanye.

Itekhnoloji yokunyibilikisa ijika ifumanisa ngaxeshanye iTB kunye neMDR-TB.

Ukufunyanwa kwe-3-in-1 TB/MDR-TB okufumanisa usulelo lwe-TB kunye nokuxhathisa amayeza okuqala (RIF/INH) kwenza ukuba unyango lwe-TB lufike ngexesha kwaye luchaneke.

I-Mycobacterium Tuberculosis Nucleic Acid kunye neRifampicin, iKit yokuFumanisa ukuKhawuleza kwe-Isoniazid (iMelting Curve)

Ufezekisa ngempumelelo uvavanyo lwe-TB oluphindwe kathathu (usulelo lwe-TB, i-RIF kunye ne-NIH Resistance) ngexesha elinye lokufumanisa!

Ngokukhawulezaisiphumo:Ifumaneka kwiiyure eziyi-1.5-2 kunye nokutolikwa kweziphumo ngokuzenzekelayo okunciphisa uqeqesho lobugcisa lokusebenza;

Isampuli yoVavanyo:I-sputum eyi-1-3 mL;

Uvakalelo oluphezulu:Uvakalelo lohlalutyo lweebhaktheriya ezingama-50/mL kwi-TB kunye ne-2x10³iibhaktheriya/mL kwiibhaktheriya ezimelana ne-RIF/INH, ukuqinisekisa ukufunyanwa okuthembekileyo nokuba imithwalo yebhaktheriya iphantsi.

Iithagethi ezininzis: I-TB-IS6110; Ukumelana ne-RIF -rpoB (507~503);

I-INH-resistance- InhA/AhpC/katG 315;

Ukuqinisekiswa koMgangatho:Ulawulo lweeseli lokuqinisekisa umgangatho wesampulu ukunciphisa izinto ezingalunganga;

Ukuhambelana okubanzi: Ukuhambelana neenkqubo ezininzi ze-PCR eziphambili ukuze kufikeleleke kwiilabhoratri ezininzi;

Ukuthotyelwa kweMigaqo ye-WHO: Ukunamathela kwizikhokelo ze-WHO zolawulo lwesifo sephepha esinganyangekiyo ngamayeza, ukuqinisekisa ukuthembeka nokufaneleka kwindlela yokusebenza kwezonyango.