Ngokwengxelo yamva nje yomhlaza wehlabathi jikelele, umhlaza wemiphunga usaqhubeka nokuba ngoyena nobangela wokusweleka okunxulumene nomhlaza kwihlabathi liphela, uthatha i-18.7% yazo zonke ezi zinto zibulalayo ngo-2022. Uninzi lwezi meko zi-Non-Small Cell Lung Cancer (NSCLC). Ngelixa ukuthembela kwembali kwi-chemotherapy kwisifo esiqhubela phambili kunikeze inzuzo encinci, i-paradigm itshintshile ngokusisiseko.
Ukufunyanwa kwezinto eziphambili ze-biomarkers, ezifana ne-EGFR, i-ALK, kunye ne-ROS1, iguqule unyango, ilususa kwindlela yokulinganisa yonke into ukuya kwisicwangciso esichanekileyo esijolise kubaqhubi bezofuzo ezizodwa zomhlaza wesigulane ngasinye.
Nangona kunjalo, impumelelo yolu nyango lwenguquko ixhomekeke ngokupheleleyo kuvavanyo oluchanekileyo noluthembekileyo lwemfuza ukuchonga into ekujoliswe kuyo kwisigulane esifanelekileyo.
I-Biomarkers ebalulekileyo: i-EGFR, i-ALK, i-ROS1, kunye ne-KRAS
Iimpawu ezine zebhayoloji zime njengeentsika kuxilongo lwemolekyuli ye-NSCLC, zikhokela izigqibo zonyango lokuqala:
-EGFR:Olona tshintsho luxhaphakileyo lunokwenzeka, ngakumbi kubantu baseAsia, ababhinqileyo, nabangatshayiyo. I-EGFR tyrosine kinase inhibitors (TKIs) njenge-Osimertinib iye yaphucula kakhulu iziphumo zesigulane.
-I-ALK:"Ukuguqulwa kwedayimane," ekhoyo kwi-5-8% yamatyala e-NSCLC. Izigulane ezine-ALK fusion-positive zihlala ziphendula ngokugqithiseleyo kwi-ALK inhibitors, ukufezekisa ukusinda kwexesha elide.
-I-ROS1:Ukwabelana ngokufana kwesakhiwo kunye ne-ALK, le "gem enqabileyo" iyenzeka kwi-1-2% yezigulane ze-NSCLC. Iindlela zonyango ezisebenzayo ezijoliswe kuzo ziyafumaneka, nto leyo eyenza ukuba ukufunyaniswa kwayo kubaluleke kakhulu.
-I-KRAS:Ngokwembali ibijongwa “njengengenangxaki,” iinguqulelo zeKRAS zixhaphakile. Ulwamkelo lwakutsha nje lwe-KRAS G12C inhibitors luguqule le biomarker ukusuka kwi-prognostic marker ukuya kwindawo ekujoliswe kuyo, ukuguqula ukhathalelo kwesi sigulana esisezantsi.
I-MMT Portfolio: Yenzelwe uQiniseko kuDidiagnostic
Ukuhlangabezana nemfuno engxamisekileyo yokuchongwa kwe biomarker echanekileyo, iMMT ibonelela ngepotfoliyo ye-CE-IVD ephawulwe ngexesha lokwenyani.Izixhobo zokufumanisa i-PCR, nganye yenziwe ngobuchwephesha be-cutting-edge ukuqinisekisa ukuzithemba kokuxilonga.
1. I-EGFR Mutation Detection Kit
-Itekhnoloji eyomeleziweyo ye-ARMS:Izixhasi ezizizo zonyusa ulwandiso oluthe ngqo kwinguqu.
-Ukutyebisa i-Enzymatic:Izithintelo ze-endonuclease zetyise imvelaphi yohlobo lwasendle, iphucula ulandelelwano oluguqukileyo kunye nokuphucula isisombululo.
-Ukuthintela ubushushu:Inyathelo elithile le-thermal linciphisa i-priming engacacanga, ngakumbi ukunciphisa imvelaphi yohlobo lwasendle.
-IziNzuzo eziPhambili:Uvakalelo olungahambelaniyo ukuya kutsho1%i-mutant allele frequency, ukuchaneka okugqwesileyo kunye nolawulo lwangaphakathi kunye ne-UNG enzyme, kunye nexesha lokuguqula ngokukhawuleza malunga120 imizuzu.
- Iyahambelana nezombini izicubu kunye neesampuli zebiopsy ezingamanzi.
- MMT EML4-ALK Fusion Kit yokubona
- Uvakalelo oluPhezulu:Ifumanisa ngokuchanekileyo ukuguqulwa kwe-fusion kunye nomda ophantsi wokufumanisa iikopi ze-20 / ukusabela.
-Ukuchaneka okugqwesileyo:Ibandakanya imigangatho yangaphakathi yokulawulwa kwenkqubo kunye ne-UNG enzyme yokuthintela ukungcoliswa kwe-carryover, ukuphepha ngokufanelekileyo ukuthintela ubuxoki kunye nokungahambi kakuhle.
-Ilula & iKhawulezayo:Ifaka umsebenzi olungelelanisiweyo, ovaliweyo wetyhubhu egqityiweyo malunga nemizuzu eyi-120.
-Ukuhambelana kwesixhobo:Iyahambelana neentlobo ezahlukeneyo eziqhelekileyoizixhobo PCR ngexesha lokwenyani, enikezela ubhetyebhetye kulo naluphi na umiselo lwebhubhoratri.
- I-MMT ROS1 Ikhithi yokubona iFusion
Uvakalelo oluPhezulu:Ibonisa ukusebenza okugqwesileyo ngokuqaphela ngokuthembekileyo okusezantsi kweekopi ezingama-20/intshukumo ekujoliswe kuyo ngokudityaniswayo.
Ukuchaneka okugqwesileyo:Ukusetyenziswa kokulawulwa kwekhwalithi yangaphakathi kunye ne-UNG enzyme iqinisekisa ukuthembeka kwesiphumo ngasinye, ukunciphisa umngcipheko weempazamo zokubika.
Ilula & iKhawulezayo:Njengenkqubo yetyhubhu evaliweyo, ayifuni amanyathelo anzima emva kokukhulisa. Iziphumo kunye neziphumo ezithembekileyo zifumaneka malunga nemizuzu eyi-120.
Ukuhambelana kwesixhobo:Yenzelwe ukuhambelana okubanzi kunye noluhlu lwee-PCR eziphambili, iququzelela ukudityaniswa lula kwi-lab workflows ekhoyo.
- Ikhithi yokubona iMMT KRAS
- Itekhnoloji eyongeziweyo ye-ARMS, iqiniswe yi-Enzymatic Enrichment kunye neTemperature Blocking.
- Ukutyebisa i-Enzymatic:Isebenzisa izithintelo ze-endonuclease ukwetyisa ngokukhethiweyo imvelaphi yohlobo lwasendle, ngaloo ndlela ityebisa ulandelelwano oluguquguqukayo kunye nokuphucula ngokubonakalayo isisombululo.
-Ukuthintela ubushushu:Yazisa inyathelo elithile lobushushu ukuphembelela ukungahambelani phakathi kwe-mutant-specific primers kunye ne-wild-type templates, ukunciphisa ngakumbi imvelaphi kunye nokuphucula ukucaciswa.
- Uvakalelo oluPhezulu:Ukufumana uvakalelo lokufumanisa i-1% ye-alleles eguquguqukayo, ukuqinisekisa ukuchongwa kokuguqulwa kobuninzi obuphantsi.
-Ukuchaneka okugqwesileyo:Imigangatho edibeneyo yangaphakathi kunye ne-UNG enzyme yokukhusela ngokuchasene neziphumo zobuxoki kunye neziphumo ezibi.
-Iphaneli eBanzi:Ibunjwe ngokufanelekileyo ukuququzelela ukuchongwa kweenguqu ezisibhozo ezahlukeneyo ze-KRAS kuzo zonke iityhubhu ezimbini zokusabela.
- Ilula & iKhawulezayo:Inika iziphumo ezinenjongo nezithembekileyo malunga nemizuzu eyi-120.
- Ukuhambelana kwesixhobo:Iqhelanisa ngaphandle komthungo kwizixhobo ezahlukeneyo zePCR, ibonelela ngezinto ezininzi kwiilabhoratri zeklinikhi.
Kutheni ukhetha iMMT NSCLC Solution?
Okubanzi: Isuti epheleleyo yezona zinto zine zibalulekileyo ze-NSCLC biomarkers.
IThekhnoloji ePhakamileyo: Izixhasi zoBunini (uKutyebisa i-Enzymatic, ukuThintelwa koBubushushu) kuqinisekisa ukuchaneka okuphezulu kunye novakalelo apho kubaluleke kakhulu.
Ukukhawuleza & Ngokufanelekileyo: I-uniform ~ 120-minute yeprotocol kuyo yonke ipotifoliyo ikhawulezisa ixesha lokunyanga.
I-Flexible & Accessibility: Iyahambelana noluhlu olubanzi lweesampuli kunye nezixhobo zePCR eziqhelekileyo, ukunciphisa imiqobo yokuphunyezwa.
Ukuqukumbela
Ngexesha le-oncology echanekileyo, i-molecular diagnostics yikhampasi ekhokela ukuhamba kwezonyango. Iikhithi zokubona ezikwinqanaba eliphezulu ze-MMT zixhobisa oogqirha ukuba benze imephu ngokuzithemba imbonakalo yemfuzo ye-NSCLC yesigulana, ivula amandla okusindisa ubomi kunyango ekujoliswe kulo.
Contact to learn more: marketing@mmtest.com
Ixesha lokuposa: Nov-05-2025