Ukumelana neentsholongwane (i-AMR) kube yenye yezona ngozi zinkulu kwimpilo yoluntu kule nkulungwane, okubangela ngokuthe ngqo ukufa kwabantu abangaphezu kwezigidi ezili-1.27 minyaka le kwaye kunegalelo ekufeni kwabantu abaphantse babe zizigidi ezi-5—le ngxaki yezempilo yehlabathi ingxamisekileyo ifuna ukuba sithathe amanyathelo ngokukhawuleza.
Kule veki yeHlabathi yoKwazisa nge-AMR (ngoNovemba 18-24), iinkokheli zempilo zehlabathi zimanyene kwikhwelo lazo:"Thatha Inyathelo Ngoku: Khusela Ixesha Lethu Langoku, Sikhusele Ikamva Lethu."Le ngxubusho igxininisa ukungxamiseka kokujongana ne-AMR, efuna imizamo edibeneyo kuzo zonke iicandelo lezempilo zabantu, impilo yezilwanyana, kunye nokusingqongileyo.
Ingozi ye-AMR idlula imida yelizwe kunye neendawo zonyango. Ngokutsho kophando lwamva nje lweLancet, ngaphandle kokungenelela okusebenzayo nxamnye ne-AMR,Ukubhubha kwabantu kwihlabathi liphela kungafikelela kwizigidi ezingama-39 ngo-2050, ngelixa iindleko zonyaka zokunyanga izifo ezinganyangekiyo ngamayeza kulindeleke ukuba zinyuke ukusuka kwi-$66 yeebhiliyoni zangoku ukuya kwi-$66 yezigidigidiI-159 yezigidigidi zeerandi.
Ingxaki ye-AMR: Inyani Enzima Engasemva Kwamanani
Ukumelana neentsholongwane (AMR) kwenzeka xa iintsholongwane—iintsholongwane, iintsholongwane, iiparasites, kunye neefungi—zingasaphenduli kumayeza aqhelekileyo okulwa neentsholongwane. Le ngxaki yezempilo yehlabathi ifikelele kwinqanaba elimangalisayo:
-Rhoqo ngemizuzu emi-5, umntu omnye uyafa ngenxa yosulelo olunganyangekiyo kumayeza okubulala iintsholongwane
-Ngu2050, i-AMR inokunciphisa i-GDP yehlabathi nge-3.8%
-96% yamazwe(186 iyonke) bathathe inxaxheba kuphando lwe-AMR lwehlabathi ngo-2024, bebonisa ukuqondwa ngokubanzi kwesi sisongelo
-Kwiiyunithi zokhathalelo oluphezulu kwezinye iindawo,ngaphezulu kwama-50% eebhaktheriya ezizimeleyobonisa ukuxhathisa ubuncinane kwi-antibiotic enye
Indlela IiAntibiotics Ezisilela Ngayo: Iindlela Zokuzikhusela ZeeMicroorganisms
Ii-antibiotics zisebenza ngokujolisa kwiinkqubo ezibalulekileyo zebhaktheriya:
-Ukwenziwa kodonga lweSeliIipenicillin ziphazamisa udonga lweeseli zebhaktiriya, zibangela ukuqhekeka nokufa kweebhaktiriya
-Imveliso yeeProteni: IiTetracyclines kunye neemacrolides zithintela ii-ribosomes zebhaktheriya, zimisa ukwenziwa kweeproteni
-Ukuphindaphinda kwe-DNA/RNA: Ii-Fluoroquinolones zithintela ii-enzymes ezifunekayo ekuphindaphindweni kwe-DNA yebhaktheriya
-Ukunyaniseka kweMembrane yeSeliIipolymyxins zonakalisa iimembrane zeeseli zebhaktheriya, nto leyo ekhokelela ekufeni kweeseli
-Iindlela zeMetabolicI-Sulfonamides ithintela iinkqubo ezibalulekileyo zebhaktheriya ezifana nokwenziwa kwe-folic acid
Nangona kunjalo, ngokukhetha kwendalo kunye nokuguquka kwezakhi zofuzo, iibhaktheriya ziphuhlisa iindlela ezininzi zokuxhathisa ii-antibiotics, kuquka ukuvelisa ii-enzymes ezingasebenziyo, ukutshintsha iinjongo zamayeza, ukunciphisa ukuqokelelwa kwamayeza, kunye nokwenza ii-biofilms.
I-Carbapenemase: "Isixhobo Esiphambili" kwiNgxaki ye-AMR
Phakathi kweendlela ezahlukeneyo zokuxhathisa, ukuveliswaii-carbapenemaixhalabisa ngokukodwa. Ezi enzymes zi-hydrolyze carbapenem antibiotics—ezidla ngokuthathwa njengeziyobisi “zokugqibela”. IiCarbapenemas zisebenza njengezixhobo “eziphambili” zebhaktiriya, ziqhekeza ii-antibiotics ngaphambi kokuba zingene kwiiseli zebhaktiriya. Iibhaktiriya ezithwele ezi enzymes—ezifanaIKlebsiella i-pneumoniaekwayeI-Acinetobacter baumannii—inokuphila ize iphindaphindeke nokuba isetyenziswa kakhulu zii-antibiotics.
Okubangela uloyiko ngakumbi kukuba, ii-genes ezifaka ii-carbapenemases zifumaneka kwizinto ze-genetic ezihambayo ezinokudlula phakathi kweentlobo ezahlukeneyo zebhaktheriya,ukukhawulezisa ukusasazeka kwebhaktheriya enganyangekiyo ngamayeza amaninzi kwihlabathi liphela.
Uxilongos: Umgca Wokuqala Wokhuselo Kulawulo lwe-AMR
Ukuxilongwa ngokuchanekileyo nangokukhawuleza kubalulekile ekulweni ne-AMR. Ukuchonga iintsholongwane ezinganyangekiyo ngexesha elifanelekileyo kunokwenza oku kulandelayo:
-Khokela unyango oluchanekileyo, uphephe ukusetyenziswa kakubi kwee-antibiotics
-Sebenzisa amanyathelo okulawula usulelo ukuthintela ukudluliselwa kweebhaktheriya ezinganyangekiyo
-Jonga iindlela zokuxhathisa ukuze unike ulwazi ngezigqibo zempilo yoluntu
Izisombululo Zethu: Izixhobo Ezintsha Zokulwa Nge-AMR Ngokuchanekileyo
Ukujongana nomngeni okhulayo we-AMR, iMacro & Micro-Test iphuhlise izixhobo ezintathu ezintsha zokufumanisa i-carbapenemase ezihlangabezana neemfuno ezahlukeneyo zeklinikhi, zinceda ababoneleli bezempilo ngokukhawuleza nangokuchanekileyo ukuba bachonge iintsholongwane ezinganyangekiyo ukuqinisekisa ukungenelela ngexesha elifanelekileyo kunye neziphumo eziphuculweyo zezigulane.
1. Isixhobo sokuFumanisa iCarbapenemase (iColloidal Gold)
Isebenzisa itekhnoloji ye-colloidal gold ukufumanisa ngokukhawuleza nangokuthembekileyo i-carbapenemase. Ifanelekile kwizibhedlele, kwiikliniki, kwanasekhaya, yenza kube lula inkqubo yokuxilonga ngokuchanekileyo.
Iingenelo ezingundoqo:
-Ukufunyanwa Okupheleleyo: Ngaxeshanye ichonga iijini ezintlanu zokuxhathisa—i-NDM, i-KPC, i-OXA-48, i-IMP, kunye ne-VIM
-Iziphumo ezikhawulezayo: Ibonelela ngeziphumo ngaphakathiimizuzu eli-15, ngokukhawuleza kakhulu kuneendlela zesintu (iintsuku ezi-1-2)
-Ukusebenza okululaAkukho zixhobo zinzima okanye uqeqesho olukhethekileyo olufunekayo, olufanelekileyo kwiindawo ezahlukeneyo
-Ukuchaneka Okuphezulu: Uvakalelo lwe-95% ngaphandle kweziphumo ezingezizo ezilungileyo ezivela kwiibhaktheriya eziqhelekileyo ezifana neKlebsiella pneumoniae okanye iPseudomonas aeruginosa
2. Ikhithi yokuFumanisa iGene yokuKhathazeka neCarbapenem (iFluorescence PCR)
Yenzelwe uhlalutyo olunzulu lwezakhi zofuzo lokuxhathisa i-carbapenem. Ilungele ukujongwa ngokupheleleyo kwiilebhu zeklinikhi, ibonelela ngokuchongwa ngokuchanekileyo kwezakhi zofuzo ezininzi zokuxhathisa i-carbapenem.
Iingenelo ezingundoqo:
-Isampuli eguquguqukayo: Ukufunyanwa ngokuthe ngqo kwiiikholoni ezicocekileyo, i-sputum, okanye i-rectal swabs—akukho nkcubekoiyadingeka
-Ukuncitshiswa kweendleko: Ifumanisa iijini ezintandathu eziphambili zokuxhathisa (i-NDM, i-KPC, i-OXA-48, i-OXA-23) i-IMP, kunye ne-VIM kuvavanyo olunye, isusa uvavanyo olungafunekiyo.
-Uvakalelo oluphezulu kunye nokuKhethekileyoUmda wokufumanisa uphantsi njenge-1000 CFU/mL, akukho ntshukumo edibeneyo nezinye iijini zokumelana ezifana ne-CTX, i-mecA, i-SME, i-SHV, kunye ne-TEM
-Ukuhambelana Okubanzi: Iyahambelana neUmzekelo-wempenduloI-AIO 800 i-POCT yeemolekyuli ezizenzekelayo ngokupheleleyo kunye nezixhobo ze-PCR eziphambili
3. I-Klebsiella pneumoniae, i-Acinetobacter baumannii, i-Pseudomonas aeruginosa kunye ne-Resistance Genes Multiplex Detection Kit (i-Fluorescence PCR)
Le khithi idibanisa ukuchonga iintsholongwane kunye neendlela zokuxhathisa ezinxulumene nazo kwinkqubo enye elungelelanisiweyo yokuchonga ngempumelelo.
Iingenelo ezingundoqo:
-Ukufunyanwa Okupheleleyo: Ichonga ngaxeshanyeiintsholongwane ezintathu eziphambili zebhaktheriya—I-Klebsiella pneumoniae, i-Acinetobacter baumannii, kunye ne-Pseudomonas aeruginosa—kwaye ichonga ii-genes ezine ezibalulekileyo ze-carbapenemase (i-KPC, i-NDM, i-OXA48, kunye ne-IMP) kuvavanyo olunye.
-Uvakalelo oluphezulu: Iyakwazi ukubona i-DNA yebhaktheriya kumanqanaba aphantsi njenge-1000 CFU/mL
-Ixhasa Isigqibo Seklinikhi: Inceda ekukhetheni unyango olusebenzayo lokulwa neentsholongwane ngokuchongwa kwangethuba kweentlobo ezichaseneyo
-Ukuhambelana Okubanzi: Iyahambelana neUmzekelo-wempenduloI-AIO 800 i-POCT yeemolekyuli ezizenzekelayo ngokupheleleyo kunye nezixhobo ze-PCR eziphambili
Ezi zixhobo zokufumanisa zibonelela iingcali zezempilo ngezixhobo zokujongana ne-AMR kumanqanaba ahlukeneyo—ukusuka kuvavanyo olukhawulezileyo lwendawo yokhathalelo ukuya kuhlalutyo oluneenkcukacha lwemfuza—ukuqinisekisa ukungenelela ngexesha elifanelekileyo kunye nokunciphisa ukusasazeka kweentsholongwane ezinganyangekiyo.
Ukulwa ne-AMR ngePrecision Diagnostics
KwiMacro & Micro-Test, sinikezela ngeekhithi zokuxilonga ezisemgangathweni ezinika amandla ababoneleli beenkonzo zempilo ngolwazi olukhawulezayo noluthembekileyo, olwenza ukuba kubekho uhlengahlengiso lonyango ngexesha elifanelekileyo kunye nolawulo olusebenzayo losulelo.
Njengoko kugxininisiwe kwiVeki yoLwazi lwe-AMR yeHlabathi, ukhetho lwethu namhlanje luya kuqinisekisa amandla ethu okukhusela izizukulwana zangoku nezexesha elizayo kwingozi yokuxhathisa iintsholongwane.
Joyina umlo wokulwa nokuxhathisa iintsholongwane—yonke into esindiswe bubomi ibalulekile.
For more information, please contact: marketing@mmtest.com
Ixesha leposi: Novemba-19-2025