ICovid-19 (2019-NCOV) ibangele amakhulu ezigidi zosulelo kunye nezigidi zokufa ukusukela ekuphunyezweni kwayo ekupheleni kuka-2019. Umbutho wezeMpilo weHlabathi (WHO)[1], eweni, iBeta, iGama, Delta kunye ne-Omicon, kunye ne-Omicron, kunye ne-Omicron Mutant Surin yeyona ngxaki iphambili kwisifo sehlabathi okwangoku. Emva kokuba wosulelwe yi-Omicron idute, iimpawu zinobulali, kodwa kubantu abakhethekileyo njengaba bantu baseMongomomom, abantu abadala, abagulayo, umngcipheko wokugula uphuphume. Imeko yokufa kwamatyala e-Omicins, iDatha yeHlabathi yeHlabathi yeHlabathi ibonisa ukuba inqanaba lokufa kwamatyala limalunga ne-0.75%, kunye ne-7 ukuya kwi-8 ukuya kuthi ga kangangesithuba seminyaka eli-8 ubudala, ngakumbi abaneminyaka engama-80 indala, idlula i-10%, ephantse ibe ngama-100 amaxesha e-influenza[2]. Ukubonakaliswa kweklinikhi yesiqhelo yi-fever, ukukhohlela, umqala owomileyo, umqala obuhlungu, iMylua, njl. Njl. Njl.
Kukho iintlobo ezine zentsholongwane ye-influenjasza: A, B, C kunye ne-D. Iindidi eziphambili ze-subtypes a (h1n1) kunye ne-H3N2, kwaye i-Hictoria kunye ne-Yamagata). Intsholongwane ye-Influenza ebangelwa yintsholongwane ye-Efweenaenza iza kubangela ukuba isifo samaxesha esibhubhini kunye ne-pandedic engalindelekanga minyaka le, ngereyithi ephezulu yemfundo. Ngokweenkcukacha-manani, malunga ne-3.4 amatyala ezigidi ezi-3.4 banyangwa ngenxa yezifo zefloweenza-njengezifo minyaka le[3].[4]. Iimpawu zeklinikhi zibandakanya umkhuhlane, intloko ebuhlungu, i-mylualgia kunye nokukhohlela. Amaqela abeka emngciphekweni, njengabasetyhini abakhulelweyo, iintsana, abantu abadala nabaguli abanesifo esinganyangekiyo, bathambekele ekufeni kwiimeko ezinzima.
I-1 Covid-19 kunye ne-Fobluenzaen.
Ukusuleleka komkhuhlane onosulelo kunye neCoVing-19 kusenokukhulisa ifuthe lesi sifo. Isifundo saseBritane sibonisa ukuba[5], xa kuthelekiswa neCovid-19 isohlwayo se-19 yodwa kuphela, umngcipheko wokonwaba koomatshini kunye nomngcipheko wokufa esibhedlele kwizikolo ezinesidivi-ezili-19 ezinosulelo lwe-Febluenzan
IKholeji yezoNyango ye-hungjang yeHuzhong yeDyunivesithi yeSayensi neTekhnoloji yapapasha isifundo[6], equka izifundo ezingama-95 ezibandakanya abaguli abangama-62,107 eCodd-19. Inqanaba lokwahlulahlula intsholongwane ye-Foungeena Virus yayiyi-2.45%, phakathi kwe-Foungeenza A inikwe umda okuphezulu. Xa kuthelekiswa neziguli kuphela ezosuleleke kuphela yiCovid-19, abaguli bosulelwe ngumngcipheko ophezulu kwiziphumo eziphezulu, kubandakanya ukwamkelwa kwe-ICU, inkxaso yomoya yomoya kunye nokufa. Nangona ukwanda kokusuleleka kwe-Co-isulele, izigulana ezinesifo sosulelo xa sijamelana nomngcipheko omkhulu weziphumo ezibi.
Uhlalutyo lwe-meta lubonisa ukuba[7], xa kuthelekiswa ne-B-hism, i-a-hism inokwenzeka ukuba isuswe yiCovid-19. Phakathi kwabaguli abayi-143 abasulelekileyo, i-74% yosuleleka ngumjelo, kwaye iipesenti ezingama-20 zosulelekile ngumjelo we-B-his. Ukunyamezelelo kunokukhokelela ekuguleni izigulana, ngakumbi phakathi kwamaqela abuthathaka njengabantwana.
Uphando kubantwana kunye nolutsha olungaphantsi kweminyaka eli-18 ebila esibhedlele okanye lwabulawa ngumkhuhlane ngexesha le-United States kwi-2021-22 ifunyenwe[8]I-phenomenon yosulelo kunye nomkhuhlane kwiCovid-19 ifanele ingqalelo. Phakathi kwamatyala obubhengezo esinezibuko lase-influenza -sza-izalisa, i-6% yasuswa yiCovid-19 kunye ne-Fosee, kunye nenxalenye ye-Febluenza enxulumene ne-fluenzan rose ukuya kwi-16%. Ukufunyanwa kubonisa ukuba abaguli abasuleleke yiCovid-19 kunye ne-Frouenza bafuna inkxaso yokuphefumla nengahlambulukiyo ngaphezulu kunabo banosulelo kuphela, kwaye batsho ukuba usulelo olunokukhokelela kwisifo esibi kakhulu ebantwaneni .
Ukufumanisa ukwahluka komkhuhlane kunye neCovide-19.
Zombini izifo ezitsha kunye ne-influenza zisuleleke kakhulu, kwaye kukho izinto ezifanayo kwezinye iimpawu zeklinikhi, ezinje ngomkhuhlane, ukukhohlela kunye neMaluli. Nangona kunjalo, izikimu zonyango kwezi nyusi zimbini zahlukile, kwaye amachiza afunyanwa asetyenziswayo ayahlukile. Ngexesha lonyango, iziyobisi zinokutshintsha ukubonakaliswa kwesi sifo, kusenza kube nzima ngakumbi ukufumanisa isifo kuphela ngeempawu. Ke ngoko, ukufumanisa ulwazi oluchanekileyo lweCovid-19 kunye ne-Fefluenza kufuneka ixhomekeke ekufumaneni intsholongwane yokuqinisekisa ukuba izigulana zinokufumana unyango olufanelekileyo nolusebenzayo.
Inani leengcebiso zokuvumelanisa ngokuxilongwa kunye nonyango zibonisa ukuba ukuchongwa ngokuchanekileyo kweCovid-19 kunye neVidiyo ye-Influenjas kuvavanyo lwelebhu kubaluleke kakhulu ekuqulunqeni isicwangciso sonyango esifanelekileyo.
"Isicwangciso sonyango se-Foudozis kunye nesiCwangciso soNyango (2020)"[9]kunye "" ne-Inluasa yokufumana isifo kunye nengcaphephe yonyango lwengcaciso engxamisekileyo (2022)"[10]Zonke zenza icace into yokuba umkhuhlane uyafana nezinye izifo eCovid-19, kwaye coud-19 uneempawu ezinobulali kwaye eziqhelekileyo ezifana nomkhuhlane, akukho lula ukwahlula umkhuhlane; Iimpawu ezinobuzaza kwaye ezibalulekileyo zibandakanya i-nyumonia eqatha, i-acpiratory yoxinzelelo lokuphefumla kunye nokungasebenzi kakuhle komzimba, okufana nolwalamano oluqinileyo lomkhuhlane noluqilima, kwaye kufuneka zahlulwe yi-Entioloss.
I-Noves Coronavirus yosulelo kunye nesicwangciso sonyango[11]Ukukhankanya ukuba usulelo lwe-Covids-19 lufanele ukwahlulwa kulosulelo lwephecana oluphezulu olubangelwa zezinye iintsholongwane.
3 Umahluko kunyango lwe-influenza kunye ne-Covidd-Lisulelo
Ngo-2019-i-NCOv kunye ne-influenza zizifo ezahlukileyo ezibangelwa ziintsholongwane ezahlukeneyo, kwaye iindlela zonyango zahlukile. Ukusetyenziswa ngokufanelekileyo kwamachiza a-adovicral kunokubangela iingxaki ezinzulu nokufa komngcipheko kwezi zifo zimbini.
Kucetyiswa ukuba usebenzise amachiza amancinci e-antivreal efana ne-Nimatvir / Ritonavir, i-Azvodine, i-azvidine, i-anticrala kunye ne-anticlolas efana ne-Ambirbumab / Romvir Mousiclonion Antiction e-Anticle in Antict injescoction eCoud-19[12].
Iziyobisi ezichasene ne-Inli ikakhulu zisebenzisa i-Neuraminidase i-Infinitors (i-Oseltamivir), i-Zanamivir), i-Himagglutinin i-Ithitor (i-hemagglutinin ithintelo (i-hemardutinin) kunye ne-ralymerase i-infitors (i-mabaloxavir), eneziphumo ezimnandi[13].
Ukukhetha irejimeni efanelekileyo ye-antivimen kubaluleke kakhulu kunyango luka-2019-quov kunye nefliki. Ke ngoko, kubaluleke kakhulu ukubona i-pathogen ngokucacileyo yokukhokela amayeza eekliniki.
4 Codd-19 / i-Ifluenze A / Ifluenza B Thuthuli-hlaluvo lwe-Nuecleid I-Nucleid I-Acid Iimveliso ze-Acid
Le mveliso ibonelela ngokukhawuleza kwaye ngokuchanekileyo oF 2019-I-NCOV, i-Forluenza a kunye ne-influenza b intsholongwane, kwaye kunceda ukwahlula-hlula kuka-2019-NCOv kunye ne-Fefluenza, izifo ezizosulelekileyo zokuphefumla ezineempawu ezifanayo zeklinikhi kodwa iindlela ezahlukeneyo zonyango. Ngokuchonga iPathogen, inokukhokela ukuphuculwa kweklinikhi yeenkqubo ekujoliswe kuzo zonyango kwaye kuqinisekiswe ukuba izigulana zinokufumana unyango olufanelekileyo ngexesha.
Isicombululo sisonke:
Ukuqokelelwa kwesampulu-Ukukhupha i-nucleid Acid - Ukuqesha Ukufunyanwa kwe-Polymerase-Polymerase Chain
Ukuchongwa ngokuchanekileyo: Chonga iCodd-19 (Orf1b, N), intsholongwane intsholongwane kunye ne-influenza b rirus kwityhubhu enye.
Inobuthathaka kakhulu: Indawo yokuhlala yeCovide-19 ziikopi ezingama-300 / ml, kunye ne-influenza a kwaye i-B intsholongwane i-500 iikopi / ml.
Isigqubuthelo esibanzi: ICovid-19 ibandakanya yonke into eyaziwayo, kunye nefuthe le-H1N1, H1NN1 2009, H5N1, njl. ukufunyanwa.
Ulawulo oluthembekileyo oluthembekileyo: Ulawulo olungenamgangatho olingeneyo / olululo, isalathiso sangaphakathi kunye ne-UDG Enzyme Doolme yoLawulo loMgangatho
Isetyenziswe ngokubanzi: iyahambelana ne-witstream fluorescence fl ye-pcr ye-PCR kwintengiso.
Ukukhutshwa ngokuzenzekelayo: nge-macro & micro-tiEstInkqubo yokukhupha i-nucleic ozenzekelayo kunye nokuhanjiswa kweerejista, ukusebenza ngokufezekileyo kunye nokungqinelana kweziphumo kuphucuka.
Ulwazi ngeMveliso
Izalathiso
I-1. I-Organtehition yezeMpilo yeHlabathi. Ukulandelela umkhondo we-SARS-cov-2 uqhawulo-msebenzi [EB / Ol / Ol (2022-12-01) [2023-01-08]. https: // www. oobani
2. Utoliko lweGerahraitive _I-Wannian: Inqanaba lokufa e-Omicron yi-7 ukuya kwi-8 ka-8 ukuya kwi-8 le-8 ukuya kwi-8 ye-FORINEA.CTP.BA0FD7091019191984l
3. Feng lz, feng s, chen t, et al. Umthwalo we-Inluenza--Vavatived Ene-Inluative-Afpatative-njengezahlulo zokunxiba eTshayina, 2006-2015: Isifundo esisekwe kuluntu [J]. I-Foungeenza Ezinye iintsholongwane zokuhlangula, 2020, 14 (2): 162-172.
4. Li l, liu yn, wu p, et al. I-Fefluenza-inxulumene nokuphefumla okuphefumlayo kwi-China, ngo-2010-15: Isifundo esekwe kuluntu [J]. Impilo yoluntu yaseLancet, 2019, 4 (9): E473-E481.
I-5. I-Sweets MC, Russell CD, Harrison E, et al. I-SIR-CoV-2 ye-CO-Elessulelo nge-Foodluenza Viasus, intsholongwane yokuphefumla ye-syncylial, okanye i-addenovirus. I-Lancet. 2022; 399 (10334): 1463-1464.
6. Yan X, li k, Lei z, Luo J, Wang Q, I-Wei S. Ukwanda kunye neziphumo ezinxulumene noko phakathi kwe-SARS-2 kunye ne-Prounia: Uhlalutyo lwenkqubo kunye nohlalutyo lweMeta. Int junge 2023; 136: 29-36.
7. UDao Tl, hoang vt, i-Colson P, kwizigidi m, i-Gautret P. Co-Sosusuleleko ye-SARS-MO-TAVENICHICS: Uhlalutyo olucwangcisiweyo kunye nohlalutyo lweMeta. J cl virol dibanisa. 2021 Sep; 1 (3): 100036.
8. Adastal K, Tastad KJ, Huang s, et al. Ukwanda kwe-SARS-Cov-2 kunye ne-Founistine County kunye neempawu zekliniki phakathi kwabantwana kunye neshumi elidlulileyo Mmwr morb fell wkly rep. 2022; (50): 1589-1596.
9. IKomiti yezeMpilo yeSizwe kunye neMpilo-ntle yeRiphabhlikhi yase China (PRC), uLawulo lweStena weZiko leSiko laseTshayina. Iprogram yonyango lwe-Founge Ijenali yaseTshayina yezifo ezosulelayo zekliniki, i-2020, 13 (6): 401-405,41,411.
I-10. Isebe le-testician likagqirha waseTshayina, isebe lamayeza oluxakekileyo lombutho wezonyango baseTshayina, i-China engxamisekileyo yonyango, iBeijing UMbutho wezoNyango oluNgxamisekileyo yeHlabathi, i-Chinam Adsmores Medical Audes. Imvumelwano yeengcali ezingxamisekileyo kwi-Fefliza yabantu abadala ekuthiwa yintsilelo kunye nonyango (i-2022). Ijenali yaseTshayina yamayeza Ononophelo Olona nyango lukhulu, 2022, 42 (12): 1013-1026.
11. I-Ofisi Jikelele yeKhomishini yezeMpilo yeLizwe neWelly State, isebe ngokubanzi lolawulo lukarhulumente lwamayeza esintu. Qaphela ngokuprintwa nokusasaza i-Novel Coronavirus yosulelo kunye nesicwangciso sonyango (udidi lweshumi).
12. Zhang fujie, zhang fujie, zhang fujie, zhuo wang, wang quanhong, et al. I-Consetsus imvume kunyango lwe-antiviral lwe-novel coronavirus osulelekileyo [J]. Ijenali yaseTshayina yezifo ezosulelayo zekliniki, 2023, 16 (1): 10-20.
13. Isebe le-testician likagqirha waseTshayina, isebe lamayeza oluxakekileyo lombutho wezonyango baseTshayina, i-China yoNyango kwezoNyango oluNgxamisekileyo, iBeijing UMbutho wezoNyango oluNgxamisekileyo yeHlabathi, i-Chinam Admocial Advist Allies Camict Audes Advings. Imvumelwano yeengcali ezingxamisekileyo kwi-Fefliza yabantu abadala ekuthiwa yintsilelo kunye nonyango (i-2022). Ijenali yaseTshayina yamayeza Ononophelo Olona nyango lukhulu, 2022, 42 (12): 1013-1026.
IXESHA LOKUQALA: UMar-29-2024