Unyango lwe-Open Precision lwe-NSCLC olune-Advanced EGFR Mutation Test

Umhlaza wemiphunga usengumngeni wezempilo kwihlabathi liphela, ubekwe njengomhlaza wesibini oxhaphakileyo. Ngowama-2020 kuphela, bekukho amatyala amatsha angaphezu kwezigidi ezi-2.2 kwihlabathi liphela. Umhlaza wemiphunga ongengoweeseli ezincinci (i-NSCLC) umele ngaphezulu kwe-80% yazo zonke izifo zomhlaza wemiphunga, nto leyo egxininisa imfuneko engxamisekileyo yezicwangciso zonyango ezijoliswe kuzo nezisebenzayo.

Utshintsho lwe-EGFR luye lwavela njengesiseko sonyango olulungiselelwe umntu ngamnye lwe-NSCLC. I-EGFR tyrosine kinase inhibitors (TKIs) zibonelela ngendlela entsha ngokuthintela imiqondiso ebangela umhlaza, ukuthintela ukukhula kwethumba, kunye nokukhuthaza ukufa kweeseli zomhlaza—konke oku kusenzeka ngelixa kunciphisa umonakalo kwiiseli eziphilileyo.

Izikhokelo eziphambili zeklinikhi, kuquka ne-NCCN, ngoku ziyalela uvavanyo lokuguqulwa kwe-EGFR ngaphambi kokuba kuqaliswe unyango lwe-TKI, ukuqinisekisa ukuba izigulana ezifanelekileyo zifumana amayeza afanelekileyo kwasekuqaleni.

Utshintsho lwe-EGFR luye lwavela njengesiseko sonyango olulungiselelwe umntu ngamnye lwe-NSCLC. I-EGFR tyrosine kinase inhibitors (TKIs) zibonelela ngendlela entsha ngokuthintela imiqondiso ebangela umhlaza, ukuthintela ukukhula kwethumba, kunye nokukhuthaza ukufa kweeseli zomhlaza—konke oku kusenzeka ngelixa kunciphisa umonakalo kwiiseli eziphilileyo.

Izikhokelo eziphambili zeklinikhi, kuquka ne-NCCN, ngoku ziyalela uvavanyo lokuguqulwa kwe-EGFR ngaphambi kokuba kuqaliswe unyango lwe-TKI, ukuqinisekisa ukuba izigulana ezifanelekileyo zifumana amayeza afanelekileyo kwasekuqaleni.

Ukwazisa iHuman EGFR Gene 29 Mutations Detection Kit (Fluorescence PCR)
Ukuchonga ngokuchanekileyo kwizigqibo zonyango eziqinisekileyo

Ikhithi yokufumanisa i-EGFR yeMacro & Micro-Test ivumela ukuchongwa ngokukhawuleza nangokuchanekileyo kwe-29 key mutations kwi-exons 18-21 kwi-tissue kunye ne-liquid biopsies—inika amandla oogqirha ukuba balungiselele unyango ngokuzithemba.

Kutheni UkhethaUvavanyo lweMacro kunye nolweMicro'sIkhithi yovavanyo lwe-EGFR?

Le khithi ibona utshintsho oluqhelekileyo lwe-EGFR gene oluyi-29 kwi-exons 18-21 kwiisampuli zezicubu okanye zegazi zezigulane ze-NSCLC, igubungela uvakalelo lwamayeza kunye neendawo zokuxhathisa ukukhokela ukusetyenziswa kwamayeza ajoliswe kuwo afana ne-gefitinib kunye ne-osimertinib.

1. 1. Ubuchwepheshe be-ARMS obuphuculweyo: I-ARMS ephuculweyo ene-patent enhancer ukuze icaciseke ngakumbi;
2. 2. Ukwandiswa kwe-Enzymatic: Kunciphisa imvelaphi yohlobo lwasendle ngokugaya i-enzymatic, ukuphucula ukuchaneka kokufunyanwa kunye nokunciphisa ukwanda okungachazwanga ngenxa yemvelaphi ephezulu ye-genomic;
3. 3. Ukuvalelwa kobushushu: Yongeza izigaba ezithile zobushushu kwinkqubo ye-PCR, inciphisa ukungalingani kwaye yonyusa ukuchaneka kokufunyanwa;
4. 4. Uvakalelo oluphezulu: Ifumanisa utshintsho oluphantsi njenge-1% yenguqu;
5. 5. Ukuchaneka Okukhulu: Ulawulo lwangaphakathi kunye ne-enzyme ye-UNG ukunciphisa iziphumo ezingezizo;
6. 6. Ukusebenza kakuhle: Iziphumo ezijolise ekufezekiseni iinjongo zingadlulanga imizuzu eli-120
7. 7. Inkxaso yeSampuli ezimbini - Yenzelwe zombini iisampulu zezicubu kunye negazi, inika ukuguquguquka kwindlela yokusebenza kweklinikhi
8. 8. Ukuhambelana okubanzi: Ihambelana kakhulu nezixhobo ze-PCR eziphambili kwimarike;
9. 9. Ixesha lokuphelelwa yimali: iinyanga ezili-12.

Khokela Unyango Ngokuzithemba
Le khithi inceda ekuphuculeni iziphumo zonyango kwaye ihlale iphambili kunokumelana nobunzima obukhulu kunye notshintsho lokumelana.

Yandisa iPotfoliyo yakho ye-Precision Oncology
Hlola uluhlu lwethu olupheleleyo lwezisombululo zokufumanisa utshintsho kwi-KRAS, BRAF, ROS1, ALK, BCR-ABL, TEL-AML1, kunye nokunye—zonke zenzelwe ukuxhasa ukhathalelo olupheleleyo oluqhutywa yi-biomarker.

Funda nzulu:https://www.mmtest.com/oncology/

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