Ukuvula unyango oluchanekileyo lwe-NSCLC ngoVavanyo oluPhezulu loGuquko lwe-EGFR

Umhlaza wemiphunga usengumceli mngeni wezempilo wehlabathi, ubekwa njengowesibini umhlaza ofunyaniswa ufunyaniswa uqheleke. Ngo-2020 kuphela, bekukho ngaphezulu kwe-2.2 yezigidi zeemeko ezintsha kwihlabathi liphela. Umhlaza wemiphunga yeseli engeyiyo encinci (NSCLC) imele ngaphezu kwe-80% yazo zonke izifo zokuxilongwa komhlaza wemiphunga, igxininisa imfuno engxamisekileyo yeendlela zonyango ezichongiweyo nezisebenzayo.

Ukuguqulwa kwe-EGFR kuye kwavela njengelitye lembombo kunyango lomntu lwe-NSCLC. I-EGFR tyrosine kinase inhibitors (TKIs) inikezela ngendlela yokuguqula ngokuthintela izibonakaliso zokuqhuba umhlaza, ukuvimbela ukukhula kwe-tumor, kunye nokukhuthaza ukufa kweseli yomhlaza-lonke ixesha linciphisa umonakalo kwiiseli eziphilileyo.

Izikhokelo zeklinikhi ezihamba phambili, ezibandakanya i-NCCN, ngoku zigunyazisa uvavanyo lokuguqulwa kwe-EGFR ngaphambi kokuba uqalise unyango lwe-TKI, ukuqinisekisa ukuba izigulane ezifanelekileyo zifumana iziyobisi ezifanelekileyo kwasekuqaleni.

Ukuguqulwa kwe-EGFR kuye kwavela njengelitye lembombo kunyango lomntu lwe-NSCLC. I-EGFR tyrosine kinase inhibitors (TKIs) inikezela ngendlela yokuguqula ngokuthintela izibonakaliso zokuqhuba umhlaza, ukuvimbela ukukhula kwe-tumor, kunye nokukhuthaza ukufa kweseli yomhlaza-lonke ixesha linciphisa umonakalo kwiiseli eziphilileyo.

Izikhokelo zeklinikhi ezihamba phambili, ezibandakanya i-NCCN, ngoku zigunyazisa uvavanyo lokuguqulwa kwe-EGFR ngaphambi kokuba uqalise unyango lwe-TKI, ukuqinisekisa ukuba izigulane ezifanelekileyo zifumana iziyobisi ezifanelekileyo kwasekuqaleni.

Ukwazisa i- Human EGFR Gene 29 Mutations Detection Kit (Fluorescence PCR)
Ukuchongwa okuchanekileyo kweZigqibo zoNyango oluziZithekileyo

Ikiti yokuchongwa kwe-EGFR yeMacro kunye neMicro-Test's yenza ukuba kuchongwe ngokukhawuleza nangokuchanekileyo kweenguqu eziphambili ezingama-29 kuzo zonke ii-exons ze-18-21 kuzo zombini iithishu kunye ne-biopsies yolwelo-ixhobisa oogqirha ukuba balungelelanise unyango ngokuzithemba.

Kutheni KhethaUvavanyo olukhulu kunye novavanyo oluncinci'sEGFR Testing Kit?

Ikiti ifumanisa i-29 eqhelekileyo ye-EGFR yokuguqulwa kofuzo kwi-exons 18-21 ukusuka kwizicubu okanye iisampulu zegazi zezigulane ze-NSCLC, ezigubungela ukuvakalelwa kweziyobisi kunye neendawo zokuchasana ukukhokela ukusetyenziswa kweziyobisi ezijoliswe kuzo njenge-gefitinib kunye ne-osimertinib.

1. 1.ITekhnoloji ye-ARMS ephuculweyo: Ii-ARMS eziphuculweyo ezinezixhasi ezinelungelo elilodwa lomenzi wechiza ukwenzela ukuba kucace kakhulu;
2. I-2.I-Enzymatic Enrichment: Ukunciphisa imvelaphi yendalo yasendle nge-enzymatic digestion, ukuphucula ukuchaneka kokuchongwa kunye nokunciphisa ukukhulisa okungekho ngqo ngenxa yemvelaphi ephezulu ye-genomic;
3. I-3.I-Temperature Blocking: Yongeza izigaba ezithile zeqondo lokushisa kwinkqubo ye-PCR, ukunciphisa ukungahambi kakuhle kunye nokwandisa ukuchaneka kokufumanisa;
4. 4.Uvakalelo oluphezulu: Ifumanisa utshintsho olusezantsi njenge-1% yokuguqulwa;
5. I-5.Ukuchaneka okukhulu: Ulawulo lwangaphakathi kunye ne-UNG enzyme yokunciphisa iziphumo zobuxoki;
6. I-6.Ukusebenza kakuhle: Iziphumo zenjongo ngaphakathi kwe-120 min
7. I-7.Inkxaso yeeSampuli ezimbini-Ilungiselelwe zombini izicubu kunye neesampuli zegazi, ezinikezela ukuguquguquka ekusebenzeni kweklinikhi
8. I-8.Ukuhambelana okubanzi: Ihambelana ngokubanzi nezixhobo zePCR eziqhelekileyo kwimarike;
9. 9.Shelf-ubomi: 12 iinyanga.

Isikhokelo soNyango ngokuzithemba
Ikiti inceda ukwandisa iziphumo zeklinikhi kwaye uhlale uphambi kokuchasana ngovakalelo olubalulekileyo kunye nokuguqulwa kokumelana.

Yandisa iPotfoliyo yakho yeOncology echanekileyo
Phonononga uluhlu lwethu olupheleleyo lwezisombululo zokufumanisa ukuguqulwa kwenguqu ye-KRAS, i-BRAF, i-ROS1, i-ALK, i-BCR-ABL, i-TEL-AML1, kunye nokunye-zonke ziyilelwe ukuxhasa ukhathalelo olubanzi oluqhutywa yi-biomarker.

Funda nzulu:https://www.mmtest.com/oncology/

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