Umhlaza wesine uxhaphakileyo phakathi kwabasetyhini kwihlabathi liphela ngokwenani lamatyala amatsha kunye nokufa ngumhlaza womlomo wesibeleko emva kwebele, i-colorectal kunye nemiphunga. Zimbini iindlela zokuthintela umhlaza womlomo wesibeleko – uthintelo lokuqala kunye nothintelo lwesibini. Uthintelo olusisiseko luthintela abokuqala umhlaza kwindawo yokuqala besebenzisa ugonyo lwe-HPV. Uthintelo lwesibini lufumanisa izilonda ezinomhlaza ngokuzivavanya kwaye zinyange phambi kokuba zibe ngumhlaza. Kukho iindlela ezintathu eziqhelekileyo ezisetyenziswayo zokuhlola umhlaza womlomo wesibeleko, nganye iyilelwe istratum ethile yezentlalo noqoqosho oko kukuthi, i-VIA, i-cytology/iPapanicolaou (Pap) uvavanyo lwe-smear kunye novavanyo lwe-HPV DNA. Kubemi ngokubanzi babasetyhini, izikhokelo zamva nje ze-WHO zowama-2021 ngoku zicebisa ukuba zihlolwe nge-HPV DNA njengovavanyo lokuqala oluqala kwiminyaka engama-30 ngezithuba zeminyaka emihlanu ukuya kwelishumi endaweni ye-Pap Smear okanye i-VIA. Uvavanyo lwe-HPV DNA lunovakalelo oluphezulu (90 ukuya kwi-100%) xa kuthelekiswa ne-pap cytology kunye ne-VIA. Kwakhona kuneendleko ezingaphezulu kuneendlela zokuhlola ezibonakalayo okanye i-cytology kwaye ifanelekile kuzo zonke izicwangciso.
Ukuzithathela iisampulu lolunye ukhetho olucetyiswe yi-WHO. ingakumbi kubafazi abangajongwanga ngokwaneleyo. Izibonelelo zokuhlola usebenzisa uvavanyo lwe-HPV oziqokeleleyo lubandakanya ukonyuka kokulula kunye nokunciphisa imiqobo yabasetyhini. Apho uvavanyo lwe-HPV lufumanekayo njengenxalenye yenkqubo yesizwe, ukhetho lokukwazi ukuzenzela iisampulu lunokukhuthaza abasetyhini ukuba bafikelele kwiinkonzo zovavanyo kunye nonyango kwaye kwakhona kuphuculwe ukhuseleko lwe-screening. Abasetyhini banokuziva bekhululekile ukuba bathathe iisampulu zabo, kunokuba baye kubona unompilo ukuze avavanye umhlaza womlomo wesibeleko.
