I-Carbapenemase

Inkcazo emfutshane:

Le khithi isetyenziselwa ukufumanisa umgangatho we-NDM, KPC, OXA-48, IMP kunye ne-VIM carbapenemases eziveliswe kwiisampuli zebhaktiriya ezifunyenwe emva kokukhuliswa kwi-vitro.

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Igama lemveliso

Ikhithi yokuFumanisa i-HWTS-OT085E/F/G/H -Carbapenemase (iGolide yeColloidal)

I-Epidemiology

Ii-antibiotics zeCarbapenem zii-antibiotics ze-β-lactam ezingaqhelekanga ezine-spectrum ebanzi ye-antibacterial kunye nomsebenzi onamandla we-antibacterial^[1]Ngenxa yokuzinza kwayo kwi-β-lactamase kunye nobuthi obuphantsi, iye yaba yenye yezona ziyobisi zibalulekileyo zokulwa neentsholongwane kunyango lwezifo ezinzulu zebhaktiriya. IiCarbapenems zizinzile kakhulu kwi-plasmid-mediated extended-spectrum β-lactamases (ESBLs), ii-chromosomes kunye ne-plasmid-mediated cephalosporinases (ii-enzymes ze-AmpC)^[2].

Iiparameters zobugcisa

Indawo ekujoliswe kuyo	I-NDM, i-KPC, i-OXA-48, i-IMP kunye ne-VIM carbapenemases
Ubushushu bokugcina	4℃ -30℃
Uhlobo lwesampulu	Iisampulu zeebhaktheriya ezifunyenwe emva kokukhuliswa
Beka ubomi kwishelufa	Iinyanga ezingama-24
Izixhobo ezincedisayo	Ayifuneki
Izinto ezisetyenziswayo ezongezelelweyo	Ayifuneki
Ixesha lokufunyaniswa	Iisampulu zeebhaktheriya ezifunyenwe emva kokukhuliswa
I-LoD	Uhlobo lwe-NDM:0.15ng/mL Uhlobo lwe-KPC: 0.4ng/mL Uhlobo lwe-OXA-48:0.1ng/mL Uhlobo lwe-IMP:0.2ng/mL Uhlobo lwe-VIM:0.3ng/mL.
Isiphumo sehoko	Kwi-NDM, KPC, OXA-48 type carbapenemase, akukho siphumo sehook esifumaneka kuluhlu lwe-100ng/mL; kwi-IMP, VIM type carbapenemase, akukho siphumo sehook esifumaneka kuluhlu lwe-1μg/mL.