I-Clostridium Difficile Glutamate Dehydrogenase (GDH) kunye neToxin A/B

I-Clostridium difficile (CD) yi-bacillus ebophelelekileyo ye-anaerobic gram-positive, eyi-flora eqhelekileyo emzimbeni womntu. Ezinye ii-flora ziya kuthintelwa ukuba zingaphindaphindeki ngenxa yee-antibiotics ezisetyenziswa kwiidosi ezinkulu, kwaye i-CD izala emzimbeni womntu ngobuninzi. I-CD yahlulwe yaba ziintlobo ezivelisa ityhefu kunye nezingezizo ezivelisa ityhefu. Zonke iintlobo ze-CD zivelisa i-glutamate dehydrogenase (GDH) xa zizala, kwaye ziintlobo ze-toxigenic kuphela ezibangela i-pathogenic. Iintlobo ezivelisa ityhefu zinokuvelisa iityhefu ezimbini, u-A kunye no-B. I-Toxin A yi-enterotoxin, enokubangela ukudumba kodonga lwamathumbu, ukungena kweeseli, ukwanda kokungena kodonga lwamathumbu, ukopha kwegazi kunye ne-necrosis. I-Toxin B yi-cytotoxin, eyonakalisa i-cytoskeleton, ibangela i-cell pyknosis kunye ne-necrosis, kwaye yonakalisa ngokuthe ngqo iiseli ze-intestinal parietal, okubangela urhudo kunye ne-pseudomembranous colitis.