I-Clostridium Difficile Glutamate Dehydrogenase (GDH) kunye neToxin A/B

I-Clostridium difficile(CD) yi-anaerobic gram-positive bacillus enyanzelekileyo, eyintyatyambo eqhelekileyo emzimbeni womntu. Ezinye iintyatyambo ziyakuthintelwa ukuba zingaphindaphindeki ngenxa yamayeza okubulala iintsholongwane asetyenziswa kwidosi enkulu, kwaye iCD ivelisa kwakhona emzimbeni womntu ngobuninzi. I-CD yahlulwe yaba ziindidi ezivelisa ityhefu nezingavelisi ityhefu. Zonke iintlobo ze-CD zivelisa i-glutamate dehydrogenase (GDH) xa ziphindaphinda, kwaye kuphela iintlobo ze-toxigenic ezibangelwa yi-pathogenic. Iintlobo ze-toxin ezivelisa i-toxin ziyakwazi ukuvelisa i-toxins ezimbini, i-A kunye ne-B. I-Toxin A yi-enterotoxin, enokubangela ukuvuvukala kwodonga lwamathumbu, ukungena kweeseli, ukunyuka kwe-intestinal wall, i-hemorrhage kunye ne-necrosis. I-Toxin B yi-cytotoxin, eyonakalisa i-cytoskeleton, ibangela i-cell pyknosis kunye ne-necrosis, kwaye yonakalise ngokuthe ngqo iiseli ze-parietal zamathumbu, okukhokelela kurhudo kunye ne-pseudomembranous colitis.