Ikiti iyasebenza kwi-pretreatment yesampuli ukuba ivavanywe, ukwenzela ukuba umhlalutyi kwisampuli akhululwe ekubopheni kwezinye izinto, ukulungiselela ukusetyenziswa kwe-in vitro diagnostic reagents okanye izixhobo zokuvavanya umhlalutyi.
Uhlobo I-arhente yokukhulula isampula ifanelekile iisampulu zentsholongwane,kwayeUhlobo lwe-II i-arhente yokukhulula isampuli ifanelekile kwiisampuli zebhaktheriya kunye nesifo sofuba.