Le khithi ilungele ukuchongwa okusemgangathweni kweendawo eziphambili zokuguqula iisampulu zesikhohlela somntu eziqokelelwe kwizigulane ezine-Tubercle bacillus positive ezikhokelela kuxhathiso lwe-mycobacterium tuberculosis isoniazid: Ingingqi ye-InhA yokukhuthaza -15C>T, -8T>A, -8T>C;Ummandla womgqugquzeli we-AhpC -12C>T, -6G>A;ukuguqulwa kwe-homozygous ye-KatG 315 codon 315G>A, 315G>C.