Ukususela ngoMeyi ka-2022, iimeko ze-mpox ziye zabikwa kumazwe amaninzi angenasiphelo kwihlabathi kunye nokuhanjiswa koluntu.
Ngomhla wama-26 ku-Agasti, uMbutho wezeMpilo weHlabathi (i-WHO) usungule ihlabathiULungiselelo oluCwangcisiweyo kunye nesiCwangciso sokuSabelaukunqanda ukuqhambuka kosulelo lwe-pox ebantwini ngolungelelwaniso lwehlabathi, lwengingqi kunye nelizwe. Oku kulandela isibhengezo semeko engxamisekileyo yezempilo yoluntu exhalabisa amazwe ngamazwe nguMlawuli-Jikelele we-WHO ngomhla we-14 kweyeThupha.
Kufuneka kuqatshelwe ukuba ukuqhambuka kwempox kweli xesha kwahlukile kuleyo ka-2022, eyayisasazeka kakhulu phakathi kwamadoda alala namadoda, kwaye izinga lokufa kwabantu abosulelekileyo lalingaphantsi kwe-1%.
Uxinzelelo oluxhaphakileyo lwakutsha nje "i-Clade Ib", eyohlukileyo ye-Clade I, inezinga eliphezulu lokusweleka. Lo mahluko mtsha waqala ukusasazeka e-DRC ngoSeptemba ophelileyo, ekuqaleni phakathi kwabathengisi ngemizimba, kwaye ngoku sele benwenwele nakwamanye amaqela, kwaye abantwana bachaphazeleka ngakumbi.
I-CDC yase-Afrika yathi kwingxelo yenyanga edlulileyo i-mpox ifunyenwe kumazwe a-10 ase-Afrika kulo nyaka, kuquka i-DRC, ebike i-96.3% yazo zonke iimeko e-Afrika kulo nyaka kunye ne-97% yokusweleka. Kuyafaneleka ukuba uqaphele ukuba phantse i-70% yamatyala e-DRC ngabantwana abangaphantsi kweminyaka eyi-15, kwaye eli qela libalelwa kwi-85% yokufa kweli lizwe.
I-Mpox yi-zoonosis ebangelwa yintsholongwane ye-mpox kunye nexesha lokufukamela iintsuku ezi-5 ukuya kwezi-21, ubukhulu becala iintsuku ezi-6 ukuya kwezi-13. Umntu osulelekileyo uya kuba neempawu ezifana nomkhuhlane, intloko ebuhlungu kunye nokudumba kwe-lymph nodes, kulandele irhashalala ebusweni nakwamanye amalungu omzimba, athi ngokuthe ngcembe akhule abe ngamaqhuma kwaye athathe isithuba esingangeveki phambi kokuba ahlatshwe. Ityala liyasulela ukususela ekuqaleni kweempawu de ukhwekhwe luwe ngokwemvelo.
I-Macro kunye ne-Micro-Test inikezela iimvavanyo ezikhawulezayo, iikiti ze-molecular kunye nezisombululo zokulandelelanisa ukufunyanwa kwentsholongwane ye-mpox, ukuncedisa ukuxilongwa kwentsholongwane ye-mpox ngexesha, ukubeka iliso kwimvelaphi yayo, umgca, ukuhanjiswa kunye nokuhluka kwe-genomic:
Monkeypox Virus AntigenIkhithi yokubona (Immunochromatography)
Isampula elula (i-rash fluid / isampuli yomphimbo) kunye nesiphumo esikhawulezayo ngaphakathi kwe-10-15 min;
Uvakalelo oluphezulu kunye ne-LoD ye-20pg / mL egqumayo i-Clade I & II;
Ukuchaneka okuphezulu ngaphandle kokusebenza kwakhona kunye nentsholongwane ye-smallpox, i-varicella zoster virus, intsholongwane ye-rubella, i-herpes simplex virus, njl.
I-OPA ye-96.4% xa ithelekiswa nee-NAATs;
Isicelo esibanzi njengamasiko, iiCDC, iikhemesti, iikliniki, izibhedlele okanye ekhaya.
I-Monkeypox-virus ye-IgM/IgG ye-Antibody Detection Kit(Immunochromatographhy)
Ukusebenza okulula kwesixhobo kunye nesiphumo esikhawulezayo ngaphakathi kwe-10 min;
Uvakalelo oluphezulu kunye neenkcukacha ezigqume iClade I & II;
Ichonga i-IgM kunye ne-IgG ukugqiba ngezigaba zosulelo lwe-mpox;
Isicelo esibanzi njengamasiko, iiCDC, iikhemesti, iikliniki, izibhedlele okanye ekhaya;
Kufanelekile ukujongwa ngomlinganiselo omkhulu wosulelo olukrokrelekayo lwempoksi.
I-Monkeypox Virus Nucleic Acid Detection Kit (Enzymatic Probe Isothermal Amplification)
Uvakalelo oluphezulu kunye ne-LoD yeekopi ze-200 / mL ene-IC, ilingana ne-florescence PCR;
Ukusebenza okulula: Isampulu yeLysed yongezwa kwityhubhu ye-reagent ye-lyophilized yokwandisa ngokuthe ngqo kwi-imfuno eyenziwe yimodyuli ezizimeleyo ze-Easy Amp System;
Ukucaciswa okuphezulu ngaphandle kokusebenza kwakhona kunye nentsholongwane ye-smallpox, intsholongwane ye-vaccinia, i-virus ye-cowpox, i-mousepox virus, i-herpes simplex virus, i-varicella-zoster virus, kunye ne-genome yabantu, njl.;
Isampula elula (i-rash fluid / i-oropharyngeal swab) kunye nesiphumo esikhawulezayo esilungileyo ngaphakathi kwe-5 min;
Ukusebenza kweklinikhi okugqwesileyo okugubungela i-Clade I & II kunye nePPA ye-100%, i-NPA ye-100%, i-OPA ye-100% kunye nexabiso le-Kappa le-1.000 xa kuthelekiswa nekhithi ye-Fluorescence PCR;
Inguqulo ye-Lyophilized efuna kuphela ukuthuthwa kobushushu begumbi kunye nokugcinwa kwenza ukuba kufikeleleke kuyo yonke imimandla;
Iimeko eziguquguqukayo kwiiklinikhi, iziko lokhathalelo lwempilo, kunye ne-Easy Amp yokufunyanwa kwimfuno;
I-Monkeypox Virus Nucleic Acid Detection Kit (Fluorescence PCR)
Ufuzo olubini olujoliswe ngovakalelo oluphezulu kunye ne-LoD yeekopi ze-200 / mL;
Iisampulu eguquguqukayo yerash fluid, i-swab yomqala kunye neserum;
Ukucaciswa okuphezulu ngaphandle kokusebenza kwakhona kunye nentsholongwane ye-smallpox, intsholongwane ye-vaccinia, i-virus ye-cowpox, i-mousepox virus, i-herpes simplex virus, i-varicella-zoster virus, kunye ne-genome yabantu, njl.;
Ukusebenza okulula: isampula esheshayo ye-lysis nge-reagent yokukhululwa kwesampulu ukuba yongezwe kwi-tube yokusabela;
Ukufunyanwa ngokukhawuleza: isiphumo ngaphakathi kwe-40 min;
Ukuchaneka okuqinisekiswe ngolawulo lwangaphakathi ngokubeka iliso kuyo yonke inkqubo yokubhaqa;
Ukusebenza kweklinikhi okugqwesileyo okugubungela i-Clade I & II kunye nePPA ye-100%, i-NPA ye-99.40%, i-OPA ye-99.64% kunye nexabiso le-Kappa lika-0.9923 xa kuthelekiswa nolandelelwano;
Inguqulo ye-Lyophilized efuna kuphela ukuthuthwa kobushushu begumbi kunye nokugcinwa kwenza ukuba kufikeleleke kuyo yonke imimandla;
Iyahambelana neeNkqubo zePCR zeFluorescence;
Iimeko eziguquguqukayo zezibhedlele, iiCDCs kunye neelebhu;
I-Orthopox Virus Universal Type/Monkeypox Virus Nucleic Acid Detection Kit (Fluorescence PCR)
I-coverage epheleleyo: ivavanya zonke iintsholongwane ze-4 ze-orthopox ezinokuchaphazela umntu kunye ne-mpox exhaphakileyo (i-Clade I & II ifakiwe) kuvavanyo olulodwa ukuphepha ukufunyanwa okuphosiweyo;
Uvakalelo oluphezulu kunye ne-LoD yeekopi ze-200 / mL;
Ukuchaneka okuphezulu ngaphandle kwe-cross reactivity kunye nezinye ii-pathogens ezibangela i-rashes njenge-herpes simplex virus, i-varicella-zoster virus, kunye ne-genome yabantu, njl.;
Ukusebenza okulula: isampuli ekhawulezayo ye-lysis ngesampulu yokukhululwa kwe-reagent ukuba yongezwe kwi-buffer enye yokusabela ityhubhu;
Ukufumanisa ngokukhawuleza: ukukhulisa ngokukhawuleza kunye nesiphumo ngaphakathi kwe-40 min;
Ukuchaneka okuqinisekiswe ngolawulo lwangaphakathi ngokubeka iliso kuyo yonke inkqubo yokubhaqa;
Iyahambelana neeNkqubo zePCR zeFluorescence;
Iimeko eziguquguqukayo zezibhedlele, iiCDCs kunye neelebhu;
InkawuVirus TypingNucleicAcidDetectionKyona (Fluorescence PCR)
Ngaxeshanye ichonga i-Clade I kunye ne-Clade II, ebaluleke kakhulu ekuqondeni iimpawu ze-epidemiological zentsholongwane, ukulandelela usulelo lwayo, kunye nokuqulunqa amanyathelo ajoliswe kuwo okuthintela nokulawula.
Uvakalelo oluphezulu kunye ne-LoD yeekopi ze-200 / mL;
Isampuli eziguquguqukayo ze-rash fluid, i-oropharyngeal swab kunye ne-serum;
Ukuchaneka okuphezulu ngaphandle kwe-cross reactivity phakathi kwe-Clade I kunye ne-II, ezinye iintsholongwane ezibangela i-rashes njenge-herpes simplex virus, i-varicella-zoster virus, kunye ne-genome yabantu, njl.;
Ukusebenza okulula: isampuli ekhawulezayo ye-lysis ngesampulu yokukhululwa kwe-reagent ukuba yongezwe kwi-buffer enye yokusabela ityhubhu;
Ukufunyanwa ngokukhawuleza: isiphumo ngaphakathi kwe-40 min;
Ukuchaneka okuqinisekiswe ngolawulo lwangaphakathi ngokubeka iliso kuyo yonke inkqubo yokubhaqa;
Inguqulo ye-Lyophilized efuna kuphela ukuthuthwa kobushushu begumbi kunye nokugcinwa kwenza ukuba kufikeleleke kuyo yonke imimandla;
Iyahambelana neeNkqubo zePCR zeFluorescence;
Iimeko eziguquguqukayo zezibhedlele, iiCDCs kunye neelebhu;
Monkey Virus Universal Whole GenomeUkufunyanwaIkhithi (Multi-PCR NGS)
Esanda kuphuhliswa i-Monkeypox Virus Whole Genome Detection Kit yi-Macro & Micro-Test yeemeko ezahlukeneyo, ezidityaniswe ne-ONT nanopore sequencer, zinokufumana i-MPXV yonke i-genome ulandelelwano kunye ne-coverage engekho ngaphantsi kwe-98% kwiiyure ze-8.
Kulula ukuyisebenzisa: itekhnoloji yokukhulisa inqanaba elinye lelungelo elilodwa lomenzi, i-genome yonke ukulandelelana kwentsholongwane ye-mpox inokufumaneka ngokukhuliswa komjikelo omnye;
I-Sensitive kwaye ichanekile: ibona iisampuli eziphantsi ukuya kwi-32CT, kunye ne-600bp amplicon nanopore sequencing inokudibana nomgangatho ophezulu we-genome assembly;
Ukukhawuleza ngokukhawuleza: I-ONT inokugqiba indibano ye-genome ngaphakathi kweeyure ze-6-8;
Ukuhambelana okubanzi: kunye ne-ONT, Qi Carbon, SALUS Pro, lllumina, MGI kunye nezinye eziphambili 2ndkunye no-3rdabalandelelanisi besizukulwana.
Ubuthathaka kakhuluIntsholongwane yeMonkey yonke iGenomeUkufunyanwaIkhithi-Illumina/MGI(Multi-PCR NGS)
Ngokumalunga namanani amakhulu e-2 ekhoyondabalandelelanisi besizukulwana kwihlabathi jikelele, iMacro & Micro-Test ikwaphuhlise i-ultra-sensitive kits eziqhelanisa nabalandelelanisi besiqhelo ukufikelela kwisampulu yoxinaniso olusezantsi lolandelelwano lwentsholongwane yentsholongwane;
Ukwandiswa okusebenzayo: izibini ze-1448 ze-200bp amplicon ye-ultra-dense primer yoyilo lwe-primer yoyilo oluphezulu lokukhulisa umgangatho kunye nokugubungela okufanayo;
Ukusebenza okulula: Ilayibrari ye-Mpox virus llumina/MGI inokufumaneka ngokukhuliswa okujikeleza kabini kwiiyure ze-4, ukuphepha amanyathelo okwakhiwa kwethala leencwadi kunye neendleko ze-reagent;
Uvakalelo oluphezulu: ufumanisa iisampulu eziphantsi ukuya kwi-35CT, ngokufanelekileyo ukuphepha iziphumo ezingezizo zobuxoki ezibangelwa ukuthotywa kweqhekeza okanye inombolo yekopi ephantsi;
Ukuhambelana okubanzi kunye nesiqhelo 2ndabalandelelanisi besizukulwana abanje ngelllumina, iSalus Pro okanye iMGI;Ukuza kuthi ga ngoku, ngaphezulu kweemeko zeklinikhi ezingama-400 zigqityiwe.
Ixesha lokuposa: Aug-28-2024