UFundo oluBalulekileyo lwe-BCR-ABL kuNyango lwe-CML

I-myelogenousleukemia engapheliyo (CML) sisifo esiyingozi se-clonal yeeseli ze-hematopoietic stem. Ngaphezu kwe-95% yezigulane ze-CML zithwala i-chromosome ye-Philadelphia (Ph) kwiiseli zabo zegazi. Kwaye i-BCR-ABL i-gene ye-fusion yenziwe ngokugqithiswa phakathi kwe-ABL proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) kwingalo ende ye-chromosome 9 (9q34) kunye ne-breakpoint cluster region (BCR) gene kwingalo ende ye-chromosome 212 (22q12). Iprotheni yayo ye-fusion encoded yile gene inomsebenzi we-tyrosine kinase (TK), kwaye isebenze iindlela zayo zokubonisa ezantsi (ezifana ne-RAS, i-PI3K, kunye ne-JAK / STAT) ukukhuthaza ukwahlukana kweeseli kunye nokuvimbela i-apoptosis yeseli, okwenza iiseli zande ngokubi, kwaye ngaloo ndlela zibangela ukuvela kwe-CML.

I-BCR-ABL fusion gene, ebalulekileyo ekuphuhliseni i-CML, isebenza njengophawu oluphambili lokuxilonga. yeCML. Ukufunyaniswa kwayo kunceda ukubeka iliso kwisigulane's impendulo kwi-tyrosine kinase inhibitors (TKIs) kwaye iqikelele ukuphindaphinda kwe-leukemia, ebalulekileyo ekulawuleni isigulane se-CML.

I-BCR-ABL yomntuI-Fusion Gene Mutation yeKit yokuFumanaukusuka kuVavanyo lweMacro kunye noNcinci ukuze kufunyanwe umgangatho we-BCR-ABL kwizigulana ze-CML, inceda ukuxilongwa kwe-CML kunye nezikhokelo kunyango olujoliswe kuyo lweklinikhi ukwandisa izicwangciso zonyango zokulawula isigulane esisebenzayo.BCR-ABL fusion gene, leyoyikubalulekilekuphuhliso lweCML,isebenza njengesiphawuli esingundoqo sokuxilongaofCML. Ukufunyanwa kwayo kuyanceda ukuesweniumonde'simpendulo kwi-tyrosine kinase inhibitors (TKIs)kwayeiqikelela ukuphindaphinda kwe-leukemia, oko ikukuthikubalulekileto esebenzayoCMLulawulo lwesigulane.

I-BCR-ABL yoMntu ye-Fusion Gene Mutation yeKit yokubona ukusuka kwi-Macro & Micro-Test yokufunyanwa ngokomgangatho we-BCR-ABL kwizigulana ze-CML, iyancedaCMLukuxilongwakwayeizikhokelounyango lweklinikhi ekujoliswe kuzotolungisaeizicwangciso zonyango zokulawula isigulane esisebenzayo.

ComprehensiveDukukhutshwa:Ngaxeshanyeukubhaqwangenxa3uhlobo oluqhelekileyo lokudibanisa (P210, P190, P230)ngenxaukhuselo olubanzi kunyeuthintelo kwiimeko eziphosiweyo;

Uvakalelo oluPhezulu:Inguqulelo yolwelo ibona ijene edityanisiweyokunye ne-LoDiikopi ezili-1000/mL,kwaye uguqulelo lyophilizedof Iikopi ezingama-500/mL;

EgqwesileyoAukuchaneka: Ikwangaphakathiulawulokunye ne-enzyme ye-UNG ukukhusela izinto zobuxoki&izinto ezingalunganga;

Ukusebenza ngokulula kunye nokusebenza kakuhle:Ukusebenza kwetyhubhu evaliweyo,simahla kwiimvelisoemva kokulungiswa,kwayeukubhaqwangaphakathiImizuzu engama-60ngenxaiziphumo ezinenjongo nezithembekileyo;

KaninziIinketho:Ulwelo kunye neenguqulelo ze-lyophilized kwiinketho zabathengi;

Ukuhambelana okubanzi:Iyahambelana neenkqubo ezininzi zePCR zokufikeleleka kwilabhu ebanzi.