Ukufunyanwa kwe-BCR-ABL ebalulekileyo yoNyango lwe-CML

I-Chronic myelogenousleukemia (CML) sisifo se-clonal esibi seeseli ze-hematopoietic stem. Ngaphezulu kwe-95% yezigulane ze-CML zithwala i-Philadelphia chromosome (Ph) kwiiseli zazo zegazi. Kwaye i-BCR-ABL fusion gene yenziwa ngokutshintshela phakathi kwe-ABL proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) engalweni ende ye-chromosome 9 (9q34) kunye ne-breakpoint cluster region (BCR) gene engalweni ende ye-chromosome 22 (22q11). Iproteni yayo ye-fusion efakwe yile gene inomsebenzi we-tyrosine kinase (TK), kwaye ivuselela iindlela zayo zokubonisa ezisezantsi (ezifana ne-RAS, PI3K, kunye ne-JAK/STAT) ukukhuthaza ukwahlukana kweeseli kunye nokuthintela i-apoptosis yeeseli, okwenza iiseli zande ngendlela enobungozi, kwaye ngaloo ndlela zibangele ukwenzeka kwe-CML.

I-BCR-ABL fusion gene, ebalulekileyo ekuphuhlisweni kwe-CML, isebenza njengophawu oluphambili lokuxilonga ye-CML. Ukufunyanwa kwayo kunceda ukujonga isigulane'impendulo ye-tyrosine kinase inhibitors (TKIs) kwaye iqikelela ukuphinda kwe-leukemia, nto leyo ebalulekileyo kulawulo olusebenzayo lwe-CML kwizigulane.

I-BCR-ABL yomntuIkhithi yokuFunction Gene Mutation Detection KitkwiMacro kunye neMicro-Test ukuze kufunyanwe i-BCR-ABL ngokwemigangatho kwizigulana ze-CML, inceda ukuxilongwa kwe-CML kwaye ikhokela unyango olujolise kulo ukuphucula amaqhinga okunyanga ukuze kulawulwe izigulane ngempumelelo. I-BCR-ABL fusion gene, nto leyoyikubalulekilekuphuhliso lwe-CML,isebenza njengophawu oluphambili lokuxilongaofI-CMLUkuchongwa kwayo kuncedaisixhobo sokubonaisigulana'simpendulo kwi-tyrosine kinase inhibitors (ii-TKI)kwayeixela kwangaphambili ukuphinda kwe-leukemia, oko ikukuthiebalulekileyoto iyasebenzaI-CMLulawulo lwezigulane.

Ikhithi yokuFumana utshintsho lwe-Human BCR-ABL Fusion Gene Mutation kwiMacro kunye neMicro-Test ukuze kufunyanwe i-BCR-ABL ngokwemigangatho kwizigulana ze-CML, uncedoI-CMLukuxilongwakwayeizikhokelounyango olujoliswe kulo lweklinikhitooptimizeamaqhinga okunyanga okulawula izigulane ngempumelelo.

IpheleleDukuvavanya:Ngaxeshanyeukufunyanwangenxa3ii-genes ezidibeneyo zokudibanisa (P210, P190, P230)ngenxaukugubungela ngokubanzi kunyeukuthintela amatyala angaphoswanga;

Uvakalelo oluphezulu:Inguqulelo yolwelo ibona iijini zokudibanisakunye neLoDyeekopi ezili-1000/mL,kwaye inguqulelo ephiliziweyoof Iikopi ezingama-500/mL;

IgqwesileAukuchaneka: Iyangaphakathiulawulokunye ne-enzyme ye-UNG ukuthintela iziphumo ezingezizo ezilungileyo& izinto ezimbi;

Ukusebenza okulula nokusebenza kakuhle:Ukusebenza kwetyhubhu evaliweyo,akukho mvelisoemva kokucutshungulwa,kwayeukufunyanwangaphakathiimizuzu engama-60ngenxaiziphumo ezichanekileyo nezithembekileyo;

KaninziIinketho：Iinguqulelo zolwelo kunye ne-lyophilized kwiinketho zabathengi;

Ukuhambelana okubanzi:Iyahambelana neenkqubo ezininzi ze-PCR ukuze kufikeleleke lula kwiilabhoratri.