Ukuhlolwa kwe-BCR-ABL ye-CML

Isifo se-myelogemiuslesia (cml) sisifo esibuhlungu seeseli ze-hematopiec. Ngaphezulu kwe-95% yezigulana ze-CML ziphethe iPhiladelphia chromosome (PH) kwiiseli zabo zegazi. Kunye ne-ger-fusion fusion ye-BCR-Ab Susion eyenziwa nguhambo phakathi kwe-ABL Protogene (i-ABSON MURINIIA VIOGE ye-chromosome 22 (22q11). Iprotheyini yayo ye-fungelo efakwe kule gene inomsebenzi weTyrosine Kinase (TK), kwaye iphucule i-rans, i-pi3k, kunye ne-jak / i-Apoptosis, i-Apoptosis, kwaye ke yenza ngalo ukwenzeka kwe-CML.

I-BRCR-Ab Fusion Fusion, ebaluleke kuphuhliso lwe-CML, isebenza njengeyona nto iphawulekayo ye-cml. Ukuqwalaselwa kwayo kunceda ukubeka esweni isigulana'Impendulo kwi-Tyrosine Kinase Toitoitors (TKIS) kwaye iqikelele i-leukemia ephindaphindwayo ye-leukemia, ebaluleke kakhulu kulawulo lwesigulana se-CML.

I-BRR-ABLI-fusion string yokufumanisa ikhithiUkusuka kwi-Macro kunye neMicro-Micro-Micro yokuhlolwa kwe-BCR-ABL kwizigulana ze-CML, Inceda ekuxilongeni nge-CML kunye nezikhokelo ekujoliswe kuzo ekuhlaleni Ukwenza impumelelo izicwangciso zonyango zolawulo olululo lwezigulana.BCR-Abl Fusione,iibalulekilekuphuhliso lwe-cml,isebenza njengeyona nto iphawulekayoofI-cml. Ukuqwalaselwa kwayo kuyancedajongaisigulana'sImpendulo kwi-Tyrosine Kinase ethintela (TKIS)kwayexela kwangaphambili i-leukemia iphindaphindeka, oko ikukuthikubalulekileto isebenzaI-cmlUlawulo lwesigulana.

I-BUSI YABASEBENZI BUSION SEED STRING ST Ukusuka kwi-Macro kunye neMicro-Micro-Micro yokuhlolwa kwe-BCR-ABL kwizigulana ze-CML, incedisaI-cmlisifokwayeIzikhokeloUnyango olujolise kwizonyangotoi-endezeIzicwangciso zonyango zolawulo olululo lwezigulana.

BanziDnxibelelanisa:Ngaxeshanyeukuqaphelakuba3I-genes eqhelekileyo (P210, p190, p230)kubaUkugubungela ngokubanzi kunyeukuthintela ukuvela kumatyala aphosiweyo;

Imvakalelo ephezulu:Inguqulelo yolwelo ibona i-vesion gesionngeLodidiyeekopi ezili-1000 / ml,kwaye Inguqulelo ye-lyophilof Iikopi ezingama-500 / ml;

NgokugqwesileyoAI-CCURACY: Ijiniulawulokunye ne-UNGLYMMMMMMME ukukhusela i-Postives eziBuxoki&ezingalunganga;

Ukusebenza ngokulula kunye nokusebenza kakuhle:Umsebenzi we-tube-tube,simahla kwiimvelisoukuqhubekeka kweposi,kwayeukuqaphelangaphakathiImizuzu engama-60kubaIziphumo kunye neziphumo ezinokuthenjwa;

KaninziIzinketho:Iinguqulelo zolwelo kunye ne-lyophilfaltions zabathengi;

Ukuhambelana ngokubanzi:Ihambelana ne-PCR ye-PCR yokufikeleleka kweelebhu ebanzi.