I-BCR-ABL ye-Fusion yoGuquko lweGene yoMntu

Inkcazelo emfutshane:

Le khithi ifanelekile ukufunyaniswa okusemgangathweni kwe-p190, i-p210 kunye ne-p230 isoforms ye-BCR-ABL yofuzo lwemfuza kwiisampulu zomongo womntu.


Iinkcukacha zeMveliso

Iithegi zeMveliso

Igama lemveliso

HWTS-GE010A-Human BCR-ABL Fusion Gene Mutation Kit Detection (Fluorescence PCR)

I-Epidemiology

I-myelogenousleukemia engapheliyo (CML) sisifo esiyingozi se-clonal yeeseli ze-hematopoietic stem.Ngaphezu kwe-95% yezigulane ze-CML zithwala i-chromosome ye-Philadelphia (Ph) kwiiseli zabo zegazi.I-pathogenesis ephambili ye-CML yile ilandelayo: I-BCR-ABL i-fusion ye-gene yenziwe ngokugqithiswa phakathi kwe-abl proto-oncogene (i-Abelson murine leukemia viral oncogene homolog 1) kwingalo ende ye-chromosome 9 (9q34) kunye nommandla weqela le-breakpoint ( BCR) ufuzo kwingalo ende yechromosome 22 (22q11);iprotheyini edityanisiweyo efakwe yile gene inomsebenzi we-tyrosine kinase (TK), kwaye isebenze iindlela zayo zokubonisa ezantsi (ezifana ne-RAS, PI3K, kunye ne-JAK / STAT) ukukhuthaza ukwahlukana kweeseli kunye nokuthintela i-apoptosis yeseli, okwenza iiseli zande ngokubi, kwaye ngaloo ndlela zibangela ukwenzeka kweCML.I-BCR-ABL yenye yezalathi ezibalulekileyo zokuxilonga ze-CML.Utshintsho oluguquguqukayo lwenqanaba loshicilelo luyisalathisi esithembekileyo sokugweba kwangaphambili kwe-leukemia kwaye ingasetyenziselwa ukuqikelela ukuphindaphinda kwe-leukemia emva konyango.

Umjelo

FAM I-BCR-ABL yemfuza yokudibanisa
VIC/HEX Ulawulo lwangaphakathi

IiParameters zobuGcisa

Ugcino Ulwelo: ≤-18℃ ebumnyameni
Beka ubomi kwishelufa Ulwelo: iinyanga ezili-9
Uhlobo loMfanekiso Iisampulu zomongo
LoD 1000 Iikopi/mL

Ukuchaza ngokuthe ngqo

 

Akukho kuphinda-phinda kusebenze kunye nezinye iijini zokudityaniswa kwe-TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, kunye ne-PML-RARa
Izixhobo Ezisebenzayo Iinkqubo ze-Biosystems ezisetyenzisiweyo 7500 Iinkqubo zePCR zeXesha langempela

Iinkqubo ze-Biosystems eziSetyenzisiweyo 7500 Iinkqubo zePCR ezikhawulezayo

I-QuantStudio® 5 Iinkqubo zePCR zeXesha langempela

SLAN-96P Iinkqubo zePCR zeXesha langempela

Inkqubo yePCR yeLightCycler®480 yeXesha langempela

I-LineGene 9600 Plus Real-Time PCR Detection System

MA-6000 Real-Time Quantitative Thermal Cycler

I-BioRad CFX96 Inkqubo yePCR yexesha lokwenyani

BioRad CFX Opus 96 Real-Time PCR System


  • Ngaphambili:
  • Okulandelayo:

  • Bhala umyalezo wakho apha kwaye uwuthumele kuthi