Ukusuka kuBungqina ukuya kwiSixhobo: Iingqiqo zikaNjingalwazi uSusan Huang malunga noLawulo lwe-MRSA kunye neNdima ye-Rapid Molecular POCT

—-“I-MRSA isengumngcipheko omkhulu. Inqwelo yezigulane inika amandla ukuhanjiswa kwezithuthi. Ulawulo aludingi nje kuphela icebo - kodwa nesantya kunye nokuchaneka kumgca ongaphambili.”

Ingozi Eqhubekayo ye-MRSA

Namhlanje, i-MRSA isengomnye wezona zizathu ziphambili zosulelo olufunyanwa esibhedlele. Kwintetho yakhe ephambili kwi-ESCMID Global 2026, uNjingalwazi uSusan Huang we-UC Irvine uveze idatha exhalabisayo: eMelika kuphela, malungaUsulelo lwegazi lwe-S. aureus oluyi-120,000zenzeka minyaka le, kunyeabantu abamalunga nama-20,000 abaswelekileyoinxulumene ngokuthe ngqo nezi zifo. I-MRSA iphakathi kwezizathu eziphambili zosulelo kwindawo yotyando, i-pneumonia, kunye nosulelo lwegazi, kwaye iyaqhubeka nokuba yimbangela ephambili yosulelo olufunyanwa esibhedlele (HAI) ebantwaneni.

Okwenza kube nzima kakhulu ukulawula i-MRSA kukuba lula kwayo ukusasazeka. Nokuba ukunxibelelana rhoqo phakathi kwesigulana nomboneleli wezempilo kunokonakalisa abasebenzi bezempilo, nokuba badlala yiphi indima okanye imeko. Nje ukuba isigulana sibe yikoloniyali ye-MRSA, imeko yesigulana inokuhlala iinyanga okanye iminyaka, nto leyo ebangela ukuba isasazeke kuthungelwano lwezempilo. Olunye uphando olucatshulwe nguNjingalwazi Huang lufumanise ukubaI-10–14% yezigulana ezine-MRSA ziqala ukosuleleka kakhulu kungekapheli nonyaka emva kokukhululwa esibhedlele.

Amaqhinga amathathu oLawulo lwangoku: Ukuyeka, Ukujolisa, Ukwandisa

UNjingalwazi Huang ucwangcise amaqhinga okulawula i-MRSA yesibhedlele akhoyo kwiimodeli ezintathu:

1. Ukuziphindezela – Amanyathelo asisiseko acwangcisiweyo, ulawulo olulinganiselweyo
Le ndlela itshintsha ingqwalasela ukusuka “ekuphelisweni” ukuya ekungeneleleni okunokwandiswa esibhedlele sonke, kubandakanya ucoceko lwezandla, ukucoca ulusu olubulala iintsholongwane, kunye neebhulethi zokuthintela usulelo ezinxulumene nezixhobo. Ngenkxaso enamandla yokujonga, amazinga osulelo lwe-MRSA anokuqiniswa. Nangona kunjalo, isiphumo silinganiselwe, kwaye uninzi lomthwalo wosulelo luhlala ngaphandle kweendonga zesibhedlele.

2. Ithagethi – Uvavanyo olusebenzayo + ukususwa kwekoloni ukuze kungenelelwe ngokuchanekileyo
Le ndlela igxininisa ekuchongeni abathwali besifo ngokuqapha okusebenzayo ukuze kuvunyelwe ukungenelela kwangoko - ngakumbi unyango lokususa ubukoloni. Ekubeni uninzi lwezifo ze-MRSA luvela kwintlungu yempumlo yesigulana, ukususa ubukoloni ekujoliswe kuyo kunokunciphisa kakhulu umngcipheko wosulelo. Kuye kwabonakala kusebenza kubantu abatyandwayo kunye nabaguli abasandul' ukuphuma esibhedlele. Inzuzo icacile, kodwa eli cebo lifuna izixhobo ezizinzileyo.

3. Yandisa – Ugutyungelo olubanzi lwezibonelelo ezininzi
Icebo le-Expand liyaqaphela ukuba izigulana zihlala zithwala iintsholongwane ezininzi ngaxeshanye, nto leyo eyenza indlela yokusebenzisa intsholongwane enye ingasebenzi kakuhle. Ukungenelela okuthe tye okufana nokucoca ulusu olubulala iintsholongwane (kunye okanye ngaphandle kwezinto ezisetyenziswa empumlweni) kunokunciphisa umthwalo we-MRSA kunye nezinye iintsholongwane ngaxeshanye. Uvavanyo olukhulu lubonise ukuba eli cebo lelona lisebenzayo ekunciphiseni i-MRSA kunye nosulelo lwegazi, ngelixa likwabonelela ngokhuseleko ngokunciphisa umthwalo wentsholongwane kwizigulane.

Icebo lokuQokelela kunye nokuSebenza: Indima yoVavanyo oluKhawulezayo nolufikelelekayo

Zonke ezi ndlela zintathu – iRelent, iTarget, kunye neExpand – zabelana ngemfuneko efanayo:ukuchongwa ngexesha elifanelekileyo nangokuchanekileyo kokungena kwe-MRSA okanye usulelo.Ngaphandle kokubhaqwa ngokukhawuleza:

-RelentayinazoIxesha elilungileimpendulo yokulungisa amanyathelo asisiseko.

-Ithagethiayinakukwazi ukuhluza nokususa ubukoloniyali ngokufanelekileyo ngaphandle kokutshintsha ngokukhawuleza.

-Yandisaiingenelo zokwazi indlela yokulawula impembelelo.

Kulapho ke iiMacro kunye neeMicro-Test zikhoyoIqonga le-POCT elizenzekelayo ngokupheleleyo le-AIO800+I-SA & MRSA ikhithi yokubona i-nucleic acidukubonelela ngebhulorho ebalulekileyo phakathi kwesicwangciso semfundo kunye nenyaniso yeklinikhi.

Isisombululo seMacro kunye neMicro-Test: Ukuvumela iQhinga ngalinyekunyeUmongoIimbonakalo

-Iinjongo:i-nuc gene(ngokukodwa kwi-S. aureus) +i-mecA gene(ukuxhathisa i-methicillin)

-Iziphumo kwiImizuzu engama-30–60(xa kuthelekiswa neentsuku ezi-2–3 zokulima)

Iintlobo zeesampulu: isikhohlela, ii-nasal swabs, iisampuli zesikhumba/zezicubu ezithambileyo

-Ukulayisha ngqo kwiityhubhu zokuqala (1.5–12 mL); ixesha elincinci lokusebenzisa

-Iifomathi ze-reagent ezimbini (ezilulwelo kunye ne-lyophilized) zokugcina/ukuthutha eziguquguqukayo

-Ulawulo longcoliseko oluneeleya ezili-11 (i-UV, i-HEPA, ukutywinwa kweparafini, njl.njl.)

-Iziqinisekiso: IVDR, NMPA, FDA, MDA

Indlela exhasa ngayo icebo ngalinye:

Ngaphaya kweendonga zesibhedlele

Iprojekthi kaNjingalwazi Huang esandul’ ukuxhaswa ngemali yezigidi zeerandi ibonisa umkhwa obanzi nokhulayo wokuthintela usulelo: ukwandisa ulawulo lwe-MRSA ngaphaya kwesibhedlele, kugxilwe kubantu abathwala emva kokukhululwa esibhedlele. Uyilo oluncinci noluzenzekelayo lwe-AIO800 luhambelana kakhulu nale filosofi inye. Eli qonga lifanelekile ukuxhasa utshintsho oluya kuvavanyo olusasazwayo - olwenza ukuba kufunyanwe i-MRSA ngokukhawuleza nangokulula ukuyisebenzisa kwiikliniki zangaphandle, kumaziko empilo oluntu, nakwiindawo zokhathalelo lwasekhaya, kanye apho ikamva lokuthintela usulelo liya khona.

Ukusuka kwiQhinga ukuya kwiSisombululo

UNjingalwazi uSusan Huang unike uluntu lwehlabathi lonke ulawulo losulelo isakhelo esicacileyo sesicwangciso-qhinga: Ukuziphindezela, Ukujolisa, kunye nokuKhulisa. Kodwa isicwangciso esingenazo izixhobo zokuphumeza sihlala singumnqweno kuphela. Iqonga le-AIO800 POCT le-Macro & Micro-Test kunye nekhithi yokufumanisa ye-SA & MRSA zibonelela ngesicwangciso-qhinga.isantya, ukulula, kunye nokufikelelekakufuneka ukuguqula la maqhinga abe yinyani yemihla ngemihla - kwiIi-ICU, iiwadi eziqhelekileyo, kwaye ekugqibeleni zidlule esibhedlele.