Ukusasazeka kwebhaktheriya enganyangekiyo yi-carbapenem kwihlabathi liphela kuyaqhubeka nokusongela unyango olusebenzayo lokulwa neentsholongwane, nto leyo eyenza ukuba ukuchongwa ngokukhawuleza kwezinto eziphilayo ezivelisa i-carbapenase kubaluleke kakhulu kunangaphambili. Ukuxhasa ukwenziwa kwezigqibo zonyango ngexesha elifanelekileyo kunye nokuhlolwa kokunganyangeki kwe-antimicrobial (AMR),Uvavanyo lweMacro kunye nolweMicroinebhongo lokwazisaIkhithi yokuFumanisa iCarbapenemasekunyeIsatifikethi se-IVDR, ukuthobela iimfuno ezingqongqo zoMgaqo we-European In Vitro Diagnostic Regulation (EU 2017/746).

Yenzelwe ukufumanisa ngokukhawuleza nangokuchanekileyo iimolekyuli ze-carbapenemase zezona genes zintandathu zibalulekileyo ngokwezonyango—I-KPC, i-NDM, i-OXA-48, i-OXA-23, i-VIM kunye ne-IMP—uvavanyo lubonelela iilabhoratri ngesisombululo esithembekileyo sokulawula usulelo, ulawulo lweentsholongwane kunye nolawulo oluphuculweyo lwezigulane. Isisombululo siyafumaneka kuzo zombini iiplatifomu zePCR zexesha langempela kunye ne-automated ngokupheleleyoU-Eudemon^TMI-AIO800Isihlalutyi sokukhulisa i-Nucleic Acid, okuvumela ukusasazwa okuguquguqukayo kwiindawo ezahlukeneyo zelebhu.

Kutheni Kubalulekile Ukufumanisa I-Carbapenema

IiCarbapenems zisaqhubeka nokuba lolunye lwezona ndlela zibalulekileyo zonyango losulelo olunzima lweentsholongwane. Nangona kunjalo, ukwanda kokuvela kwezinto eziphilayo ezivelisa i-carbapenemase kuye kunciphisa kakhulu ukusebenza kwazo kwezonyango.

Ngokutsho kweUmbutho wezeMpilo weHlabathi (i-WHO), ukumelana neentsholongwane kuphakathi kwezona zisongelo ziphambili kwimpilo yoluntu kwihlabathi liphela, ngelixa ii-Enterobacteriales (CRE) ezimelana ne-carbapenem zibonwa njengenye yezona pathogens ziphambili ezifuna ukubekwa esweni rhoqo kunye nokuxilongwa ngokukhawuleza.

Ukuchongwa kwangoko kwee-molecular ze-carbapenemase genes kwenza iingcali zezempilo zikwazi:

• · Qalisa unyango olufanelekileyo lokulwa neentsholongwane ngokukhawuleza
• · Xhasa iinkqubo zolawulo lweentsholongwane
• · Sebenzisa amanyathelo okuthintela usulelo kunye nokulawula ngexesha elifanelekileyo
• · Jonga ukusasazeka kwezinto eziphilayo ezinganyangekiyo kwiindawo zonyango

Ukujolisa kwiCarbapenemas eziSebenza kakhulu kwiKliniki

Uvavanyo lweMacro kunye neMicro-Test ngaxeshanye lufumanisa iijini ezintandathu eziphambili zokuxhathisa ezibangela uninzi lwezifo ezichasene ne-carbapenem ezibalulekileyo ngokwezonyango.

Uvavanyo lwe-PCR olukhawulezayo lwezigqibo zeklinikhi eziqinisekileyo

Xa kuthelekiswa neendlela eziqhelekileyo ze-phenotypic, ukufunyanwa kweemolekyuli okusekwe kwi-PCR kunika uvakalelo oluphezulu, ukucaca kunye nexesha lokutshintsha. Ukuchongwa ngokukhawuleza kwezakhi zofuzo zokuxhathisa kunceda oogqirha ukuba benze izigqibo zonyango ezisekelwe kubungqina ngelixa bexhasa ulawulo losulelo esibhedlele kunye nokubekwa kweliso lokuxhathisa iintsholongwane.

Isisombululo sokuFumanisa iCarbapenemase esiQinisekisiweyo yi-IVDR

-Sukufunyanwa ngokukhawulezaI-KPC, i-NDM, i-OXA-48, i-OXA-23, i-VIM kunye ne-IMPkwiindawo ezikhupha izikhwehlela zabantu kunye nenkcubeko;

-Ukuchaneka okuphezulu okungenazo iindlela zokudibana neentsholongwane ezingezizo ezijoliswe kuzo okanye iijini zokumelana nezifo;

-Uvakalelo oluphezulu ukuya kuthi ga kwi100 CFU/mL or Iikopi ezingama-500/mL; 

-Ukuhambelana Okubanzi kunye ne-ABI 7500, i-SLAN-96P kunye nezinye iinkqubo ze-PCR zexesha langempela;

Ukuzenzekelayo okugcweleyo kuvuliweU-Eudemon^TM I-AIO800

II-AIO800idibanisa ukulungiswa kweesampuli, ukukhutshwa kwe-nucleic acid, ukwandiswa kunye nokutolikwa kweziphumo kwiqonga elinye elincinci, inikezela ngovavanyo lweemolekyuli olukhawulezayo noluthembekileyo ngexesha elincinci lokusebenza.

-Isampuli yokuphendula umsebenzi ozenzekelayo ngokupheleleyo.

-Iziphumo ezikhawulezayo malunga nemizuzu engama-80.

-Inkqubo yokulawula ungcoliseko edibeneyo iqinisekisa iziphumo ezichanekileyo nezithembekileyo.

Ukuxhasa Ulawulo Olungcono Lwe-Antimicrobial

Ngesatifikethi se-IVDR, iMacro kunye neMicro-Test zibonisa ngakumbi ukuzinikela kwayo ekuboneleleni ngezisombululo zokuxilonga iimolekyuli ezikumgangatho ophezulu kwiilabhoratri kulo lonke elaseYurophu nakwihlabathi liphela.

Isisombululo sokuFumanisa iCarbapenemase esiqinisekiswe yi-IVDR senza ababoneleli bezempilo bakwazi ukuqinisa ukujonga ukumelana nokulwa neentsholongwane, ukuphucula amaqhinga okulawula usulelo kunye nokubonelela ngezigqibo zonyango ezichanekileyo ngakumbi kwizigulana ezijongene nosulelo lweentsholongwane oluchasene namayeza amaninzi.

Ukuxilongwa Ngokuchanekileyo Kubumba Ikamva Elingcono.

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