I-PCT / IL-6 Idibeneyo

I-PCT yi-precursor ye-calcitonin, eyi-glycoprotein eyenziwe nge-116 amino acids.Isixa semolekyuli simalunga ne-12.8kd.Ayinamsebenzi wehomoni.Ngaphantsi kweemeko ze-physiological, i-PCT idityaniswe kakhulu kwaye ifihliwe ngeeseli ze-thyroid C.Ngexesha losulelo lwebhaktheriya, i-macrophages kunye ne-monocytes esibindi, i-lymphocytes kunye neeseli ze-endocrine kwimiphunga kunye nezicubu zamathumbu zidibanisa kwaye zikhuphe inani elikhulu le-PCT phantsi kwesenzo se-endotoxin, i-tumor necrosis factor-α kunye ne-interleukin-6, ekhokelela ekunyuseni okukhulu. kumanqanaba e-serum PCT.
I-Interleukin-6 yi-cytokine ebonakaliswe yi-immune system ngexesha lokulimala kokuqala kunye nokusuleleka.Iveliswa yi-fibroblasts, i-monocytes / macrophages, i-T lymphocytes, i-lymphocytes ye-B, iiseli ze-epithelial, i-keratinocytes, kunye neeseli ezahlukeneyo zethumba.I-IL-6 yenziwe ngamatyathanga amabini e-glycoprotein, enye ikhonkco ye-α ene-molecular weight 80kd;enye yi-β chain enobunzima bemolekyuli ye-130kd[5].Ukuba umzimba womntu ukhuthazwa kukuvuvukala, amanqanaba e-IL-6 aphakama ngokukhawuleza, nto leyo idibanisa impendulo yesigaba esinzima sesibindi kwaye ikhuthaza ukuveliswa kweeprotheni zesigaba esibuhlungu njenge-C-reactive protein (CRP) kunye ne-serum amyloid A (SAA). ).Ke ngoko, i-IL-6 ngowona mqondiso wokuqala wokunyuka xa ukuvuvukala kwenzeka.