Amayeza oKhuseleko lweAspirin

I-Aspirin, njengeyeza elisebenzayo le-anti-platelet aggregation drug, lisetyenziswa ngokubanzi ekuthinteleni nasekunyangelweni kwezifo ze-cardiovascular and cerebrovascular.Uphononongo lufumanisa ukuba ezinye izigulane zifunyenwe zingakwazi ukuthintela ngokufanelekileyo umsebenzi weeplatelet nangona ukusetyenziswa kwexesha elide le-aspirin ye-dose ephantsi, oko kukuthi, ukuxhathisa i-aspirin (AR). Izinga limalunga nama-50% -60%, kwaye kukho umahluko ocacileyo wobuhlanga. I-Glycoprotein IIb / IIIa (GPI IIb / IIIa) idlala indima ebalulekileyo kwi-platelet aggregation kunye ne-thrombosis enzima kwiindawo zokulimala kwe-vascular. Uphononongo lubonise ukuba i-polymorphisms ye-gene idlala indima ebalulekileyo ekuxhathiseni i-aspirin, ngokukodwa igxininise kwi-GPIIIa P1A1 / A2, PEAR1 kunye ne-PTGS1 i-polymorphisms ye-gene. I-GPIIa P1A2 yeyona geni iphambili yokuxhathisa i-aspirin. Ukuguqulwa kwenguqu kule gene kuguqula isakhiwo se-GPIIb / IIIa receptors, okubangelwa ukudibanisa phakathi kweeplatelet kunye neplatelet aggregation. Uphononongo lufumene ukuba ukuphindaphinda kwe-P1A2 alleles kwizigulane ezinganyangekiyo kwi-aspirin kwakuphezulu kakhulu kunezigulana ezithintekayo kwi-aspirin, kwaye izigulane ezine-P1A2 / A2 zokuguqulwa kwe-homozygous zazingasebenzi kakuhle emva kokuthatha i-aspirin. Izigulane ezine-P1A2 alleles eziguquguqukayo eziphantsi kwe-stenting zinezinga lesiganeko se-subacute thrombotic esiphindwe kahlanu kune-P1A1 izigulane zohlobo lwe-homozygous zasendle, ezifuna iidosi eziphezulu ze-aspirin ukufezekisa iziphumo ze-anticoagulant. I-PEAR1 GG allele iphendula kakuhle kwi-aspirin, kunye nezigulane ezine-AA okanye i-AG genotype ethatha i-aspirin (okanye idibaniswe ne-clopidogrel) emva kokufakelwa kwe-stent ine-infarction ephezulu ye-myocardial kunye nokufa. I-PTGS1 GG genotype inomngcipheko omkhulu wokumelana ne-aspirin (HR: 10) kunye neziganeko eziphezulu ze-cardiovascular events (HR: 2.55). I-AG genotype inomngcipheko ophakathi, kwaye ingqalelo esondeleyo kufuneka ihlawulwe kwisiphumo sonyango lwe-aspirin. I-AA genotype ivakalelwa ngakumbi kwi-aspirin, kwaye iziganeko zeziganeko ze-cardiovascular zincinci. Iziphumo zobhaqo zale mveliso zimele kuphela iziphumo zofuzo lwabantu be-PEAR1, PTGS1, kunye ne-GPIIIa.