Amayeza oKhuseleko lwe-Aspirin

I-Aspirin, njengeyeza elisebenzayo lokulwa nokuhlanganiswa kweplatelet, isetyenziswa kakhulu ekuthinteleni nasekunyangeni izifo zentliziyo kunye nemithambo yegazi. Olu phononongo lufumanise ukuba ezinye izigulana zifunyenwe zingakwazi ukuthintela ngempumelelo umsebenzi weeplatelet nangona kusetyenziswa i-aspirin ixesha elide, oko kukuthi, ukumelana ne-aspirin (AR). Izinga limalunga ne-50%-60%, kwaye kukho umahluko ocacileyo wobuhlanga. I-Glycoprotein IIb/IIIa (GPI IIb/IIIa) idlala indima ebalulekileyo ekuhlanganisweni kweplatelet kunye ne-thrombosis ebukhali kwiindawo zokwenzakala kwemithambo yegazi. Izifundo zibonise ukuba ii-polymorphisms ze-gene zidlala indima ebalulekileyo ekumelaneni ne-aspirin, ikakhulu zigxile kwi-GPIIIa P1A1/A2, PEAR1 kunye ne-PTGS1 gene polymorphisms. I-GPIIIa P1A2 yeyona gene iphambili yokuxhathisa i-aspirin. Utshintsho kule gene lutshintsha ulwakhiwo lwee-receptors ze-GPIIb/IIIa, nto leyo ebangela unxibelelwano oludibeneyo phakathi kweeplatelet kunye nokuhlanganiswa kweplatelet. Olu phononongo lufumanise ukuba ukuphindaphindeka kwee-allele ze-P1A2 kwizigulana ezinganyangekiyo yi-aspirin kwakuphezulu kakhulu kunezigulana ezinganyangekiyo yi-aspirin, kwaye izigulana ezine-P1A2/A2 homozygous mutations zazingasebenzi kakuhle emva kokuthatha i-aspirin. Izigulana ezine-allele ze-P1A2 ezitshintshiweyo ezisebenzisa i-stenting zine-subacute thrombotic event rate ephindwe kahlanu kunezigulana ze-P1A1 homozygous wild-type, ezifuna iidosi eziphezulu ze-aspirin ukuze kufezekiswe iziphumo zokulwa nokugabha kwegazi. I-allele ye-PEAR1 GG isabela kakuhle kwi-aspirin, kwaye izigulana ezine-genotype ye-AA okanye ye-AG ezithatha i-aspirin (okanye zidityaniswe ne-clopidogrel) emva kokufakelwa kwe-stent zine-myocardial infarction ephezulu kunye nokufa. I-genotype ye-PTGS1 GG inomngcipheko ophezulu wokunganyangeki yi-aspirin (HR: 10) kunye neziganeko eziphezulu ze-cardiovascular (HR: 2.55). I-genotype ye-AG inomngcipheko ophakathi, kwaye kufuneka kuqwalaselwe kakhulu impembelelo yonyango lwe-aspirin. I-genotype ye-AA inovelwano ngakumbi kwi-aspirin, kwaye iziganeko ze-cardiovascular accine ziphantsi kakhulu. Iziphumo zokufumanisa zale mveliso zimele kuphela iziphumo zokufumanisa ze-PEAR1, PTGS1, kunye ne-GPIIIa yabantu.