I-Mycobacterium Tuberculosis Nucleic Acid kunye neRifampicin Resistance

I-Mycobacterium tuberculosis, kungekudala njenge-Tubercle bacillus, i-TB, yintsholongwane ebangela isifo sephepha. Okwangoku, amayeza okuqala okulwa nesifo sephepha asetyenziswa rhoqo aquka i-isoniazid, i-rifampicin kunye ne-hexambutol, njl. Amayeza amabini okulwa nesifo sephepha aquka i-fluoroquinolones, i-amikacin kunye ne-kanamycin, njl. Amayeza amatsha aphuhlisiwe yi-linezolid, i-bedaquiline kunye ne-delamani, njl. Nangona kunjalo, ngenxa yokusetyenziswa gwenxa kwamayeza okulwa nesifo sephepha kunye neempawu zesakhiwo sodonga lweseli lwe-mycobacterium tuberculosis, i-mycobacterium tuberculosis ikhula ukumelana namayeza okulwa nesifo sephepha, nto leyo ezisa imingeni enzima ekuthinteleni nasekunyangeni isifo sephepha.

I-Rifampicin isetyenziswa kakhulu kunyango lwe-pulmonary tuberculosis ukususela ngasekupheleni kweminyaka yoo-1970, kwaye inempembelelo ebalulekileyo. Ibilukhetho lokuqala ukufinyeza i-chemotherapy yezigulane ze-pulmonary tuberculosis. Ukuxhathisa kwe-rifampicin kubangelwa ikakhulu kukuguquka kwe-rpoB gene. Nangona amayeza amatsha okulwa nesifo sephepha ephuma rhoqo, kwaye ukusebenza kakuhle kwezonyango kwezigulane ze-pulmonary tuberculosis nako kuqhubekile nokuphucuka, kusekho ukunqongophala kwamayeza okulwa nesifo sephepha, kwaye imeko yokusetyenziswa kwamayeza angenangqondo kwiklinikhi iphezulu. Ngokucacileyo, isifo sephepha iMycobacterium kwizigulane ezine-pulmonary tuberculosis asinakubulawa ngokupheleleyo ngexesha elifanelekileyo, nto leyo ekugqibeleni ekhokelela kumanqanaba ahlukeneyo okuxhathisa amayeza emzimbeni wesigulane, yandise ixesha lesifo, kwaye yonyusa umngcipheko wokufa kwesigulane.