Human Cytomegalovirus (HCMV) Nucleic Acid

I-cytomegalovirus yabantu (i-HCMV) lilungu elinelona genome likhulu kwintsapho ye-herpes virus kwaye inokufaka iiprotheni ezingaphezu kwama-200.I-HCMV ithintelwe kancinci kuluhlu olubambayo ebantwini, kwaye akukabikho modeli yezilwanyana yosulelo lwayo.I-HCMV inomjikelezo ocothayo kunye nexesha elide lokuphindaphinda ukwenza i-intranuclear inclusion body, kwaye iqalise ukuveliswa kwemizimba ye-perinuclear kunye ne-cytoplasmic kunye nokuvuvukala kweeseli (iiseli ezinkulu), ngoko ke igama.Ngokutsho kwe-heterogeneity ye-genome kunye ne-phenotype, i-HCMV inokwahlulwa ibe yintlobo ngeentlobo zeentlobo, phakathi kwazo kukho ukuhluka okuthile kwe-antigenic, nangona kunjalo, akukho kubaluleka kwekliniki.

Usulelo lwe-HCMV lusulelo lwenkqubo, olubandakanya amalungu amaninzi ngokwezonyango, luneempawu ezintsonkothileyo nezahlukeneyo, luthe cwaka kakhulu, kwaye lunokubangela izigulane ezimbalwa ukuba zenze izilonda zamalungu amaninzi kuquka i-retinitis, i-hepatitis, inyumoniya, i-encephalitis, i-colitis, i-monocytosis, kunye ne-thrombocytopenic. ipurpura.Usulelo lwe-HCMV luxhaphake kakhulu kwaye lubonakala lusasazeka kwihlabathi jikelele.Ixhaphake kakhulu kubemi, kunye namazinga eziganeko ze-45-50% kunye nangaphezulu kwe-90% kumazwe aphuhlisiwe nasakhulayo, ngokulandelanayo.I-HCMV inokulala emzimbeni ixesha elide.Nje ukuba ukhuselo lomzimba lube buthathaka, intsholongwane iya kwenziwa ukuba ibangele izifo, ngakumbi usulelo oluphindaphindiweyo kwizigulana ze-leukemia kunye nezigulane ezifakelwayo, kwaye zingabangela i-necrosis ye-organ etshintshwe kwaye ibeke engozini ubomi bezigulane kwiimeko ezinzima.Ukongeza kokubeleka, ukuphuphuma kwesisu kunye nokunikezelwa kwangaphambi kwexesha ngokusuleleka kwi-intrauterine, i-cytomegalovirus inokubangela ukukhubazeka kokuzalwa, ngoko ke usulelo lwe-HCMV luyakwazi ukuchaphazela ukhathalelo lwangaphambi kokubeleka kunye nasemva kokubeleka kunye nomgangatho wabantu.