Ingcamango yethumba
Ithumba sisidalwa esitsha esakhiwe kukwanda okungaqhelekanga kweeseli emzimbeni, ezidla ngokubonakala njengobunzima bezicubu ezingaqhelekanga (iqhuma) kwindawo yendawo yomzimba. Ukwakhiwa kwethumba sisiphumo sokuphazamiseka okunzulu kokulawulwa kokukhula kweeseli phantsi kwesenzo sezinto ezahlukeneyo ze-tumor. Ukwanda okungaqhelekanga kweeseli ezikhokelela ekubunjweni kwethumba kubizwa ngokuba yi-neoplastic proliferation.
Ngo-2019, iSeli yoMhlaza ipapashe inqaku mva nje. Abaphandi bafumanise ukuba i-metformin inokuthintela ngokubonakalayo ukukhula kwethumba kwimeko yokuzila ukutya, kwaye yacebisa ukuba indlela ye-PP2A-GSK3β-MCL-1 inokuba yinto ekujoliswe kuyo entsha yonyango lwethumba.
Umahluko ophambili phakathi kwe-benign tumor kunye ne-tumor enobungozi
I-Benign tumor: ukukhula okucothayo, i-capsule, ukukhula okukhulayo, ukutyibilika ukuya kwi-touch, umda ocacileyo, akukho metastasis, i-prognosis ilungile, iimpawu zoxinzelelo lwengingqi, akukho mzimba uphela, ngokuqhelekileyo akubangeli ukufa kwezigulana.
I-tumor enobungozi (umhlaza): ukukhula okukhawulezayo, ukukhula okuphazamisayo, ukunamathela kwizicubu ezijikelezileyo, ukungakwazi ukuhamba xa uchukunyiswa, umda ongacacanga, i-metastasis elula, ukuphindaphinda ngokulula emva kokunyanga, umkhuhlane ophantsi, ukungabikho kokutya kwinqanaba lokuqala, ukunciphisa umzimba, ukuncipha okukhulu, i-anemia kunye nomkhuhlane kwinqanaba lokugqibela, njl. Ukuba ayiphathwanga ngexesha, idla ngokukhokelela ekufeni.
"Ngenxa yokuba i-benign tumors kunye ne-tumor enobungozi ayinayo kuphela ukubonakaliswa kweklinikhi ehlukeneyo, kodwa okona kubaluleke kakhulu, i-prognosis yabo ihluke, ngoko ke xa ufumana i-gap emzimbeni wakho kunye neempawu ezingentla, kufuneka ufune iingcebiso zonyango ngexesha."
Unyango lomntu ngamnye lwethumba
Iprojekthi yeGenome yoLuntu kunye neProjekthi yeHlabathi yeGenome yoMhlaza
IProjekthi ye-Human Genome, eyasungulwa ngokusemthethweni e-United States ngo-1990, ijolise ekuvuleni zonke iikhowudi malunga ne-100,000 yemfuza emzimbeni womntu kwaye izoba i-spectrum yemfuza yabantu.
Ngo-2006, iProjekthi ye-Cancer Genome yaMazwe ngaMazwe, eyasungulwa ngokudibeneyo ngamazwe amaninzi, lolunye uphando lwezenzululwazi oluphambili emva kweProjekthi ye-Human Genome.
Iingxaki eziphambili kunyango lwethumba
Ukuxilongwa komntu ngamnye kunye nonyango = Ukuxilongwa komntu ngamnye + iziyobisi ezijoliswe kuzo
Kwizigulana ezininzi ezahlukeneyo ezinesifo esifanayo, indlela yonyango kukusebenzisa iyeza elifanayo kunye nedosi esemgangathweni, kodwa eneneni, izigulana ezahlukeneyo zinomohluko omkhulu kwisiphumo sonyango kunye neempendulo ezibi, kwaye ngamanye amaxesha lo mahluko ude ubulale.
Unyango lwamachiza ekujoliswe kulo luneempawu zokubulala okukhethiweyo kakhulu kweeseli zethumba ngaphandle kokubulala okanye kunqabile nje ukonakalisa iiseli eziqhelekileyo, ezineziphumo ebezingalindelekanga ezincinci, eziphucula ngempumelelo umgangatho wobomi kunye nesiphumo sonyango lwezigulane.
Ngenxa yokuba unyango olujoliswe kuyo lwenzelwe ukuhlasela iimolekyuli ezithile ekujoliswe kuzo, kuyimfuneko ukufumanisa i-tumor genes kwaye ibone ukuba ngaba izigulane zineethagethi ezihambelanayo ngaphambi kokuthatha iziyobisi, ukwenzela ukuba zenze isiphumo sokunyanga.
Ukufumanisa i-tumor gene
Ukufumanisa i-tumor gene yindlela yokuhlalutya kunye nokulandelelana kwe-DNA / RNA yeeseli zethumba.
Ukubaluleka kokufunyaniswa kofuzo lwe-tumor kukukhokela ukhetho lwechiza lonyango lonyango (iziyobisi ekujoliswe kuzo, i-immune checkpoint inhibitors kunye nolunye ugawulayo olutsha, unyango lwasemva kwexesha), kunye nokuxela kwangaphambili i-prognosis kunye nokuphindaphinda.
Izisombululo ezibonelelwa yi-Acer Macro & Micro-Test
I-EGFR yoMntu yeGene 29 yeKhithi yokubona iiNguqu (i-Fluorescence PCR）
Isetyenziselwa ukufunyaniswa komgangatho woguquko oluqhelekileyo kwi-exon 18-21 ye-EGFR yofuzo kwizigulane zomhlaza wemiphunga ezingeyiyo encinci yabantu kwi-vitro.
1. Ukuqaliswa kokulawulwa komgangatho wereferensi yangaphakathi kwinkqubo inokubeka iliso ngokubanzi inkqubo yovavanyo kunye nokuqinisekisa umgangatho wokulinga.
2. Uvakalelo oluphezulu: izinga lokuguqulwa kwe-1% linokubonwa ngokuzinzileyo kwimvelaphi ye-3ng / μL yesisombululo sasendle se-nucleic acid reaction.
3. Ukucaciswa okuphezulu: akukho mpendulo enqamlezileyo kunye neziphumo zokubona uhlobo lwasendle lwe-DNA ye-genomic yabantu kunye nezinye iintlobo eziguqukayo.
KRAS 8 Ikhithi yokuFumana iiNguqu (Fluorescence PCR)
Iindidi ezisibhozo zotshintsho kwi-codons 12 kunye ne-13 ye-K-ras gene esetyenziselwa ukufumanisa umgangatho we-DNA ekhutshwe kumacandelo e-pathological afakwe kwiparafini yabantu kwi-vitro.
1. Ukuqaliswa kokulawulwa komgangatho wereferensi yangaphakathi kwinkqubo inokubeka iliso ngokubanzi inkqubo yovavanyo kunye nokuqinisekisa umgangatho wokulinga.
2. Uvakalelo oluphezulu: izinga lokuguqulwa kwe-1% linokubonwa ngokuzinzileyo kwimvelaphi ye-3ng / μL yesisombululo sasendle se-nucleic acid reaction.
3. Ukucaciswa okuphezulu: akukho mpendulo enqamlezileyo kunye neziphumo zokubona uhlobo lwasendle lwe-DNA ye-genomic yabantu kunye nezinye iintlobo eziguqukayo.
I-ROS1 ye-Fusion Gene Mutation yeKit yoMntu yokuFumana (i-Fluorescence PCR)
Isetyenziselwa ukubona ngokusemgangathweni iintlobo ezili-14 zoguqulo lwe-ROS1 yofuzo lwemfuza kubantu abangengabo abancinci abanomhlaza wemiphunga kwi-vitro.
1. Ukuqaliswa kokulawulwa komgangatho wereferensi yangaphakathi kwinkqubo inokubeka iliso ngokubanzi inkqubo yovavanyo kunye nokuqinisekisa umgangatho wokulinga.
2. Uvakalelo oluphezulu: iikopi ze-20 zokuguqulwa kwe-fusion.
3. Ukucaciswa okuphezulu: akukho mpendulo enqamlezileyo kunye neziphumo zokubona uhlobo lwasendle lwe-DNA ye-genomic yabantu kunye nezinye iintlobo eziguqukayo.
IKit ye-EML4-ALK Fusion yeGene yoMntu yokuFumana (i-Fluorescence PCR)
Isetyenziselwa ukufumanisa ngokusemgangathweni iintlobo ze-12 zokuguqulwa kwe-EML4-ALK yofuzo lwe-fusion kwizigulane zomhlaza wemiphunga yeseli yabantu engeyincinci kwi-vitro.
1. Ukuqaliswa kokulawulwa komgangatho wereferensi yangaphakathi kwinkqubo inokubeka iliso ngokubanzi inkqubo yovavanyo kunye nokuqinisekisa umgangatho wokulinga.
2. Uvakalelo oluphezulu: iikopi ze-20 zokuguqulwa kwe-fusion.
3. Ukucaciswa okuphezulu: akukho mpendulo enqamlezileyo kunye neziphumo zokubona uhlobo lwasendle lwe-DNA ye-genomic yabantu kunye nezinye iintlobo eziguqukayo.
IKit ye-BRAF yoMntu ye-V600E yokuFundisa iNguqu (i-Fluorescence PCR)
Isetyenziselwa ukubona ngokomgangatho ukuguqulwa kofuzo lwe-BRAF ye-V600E kwiisampulu zeparafini ezifakelelwe kwi-melanoma yabantu, umhlaza we-colorectal, umhlaza wamadlala kunye nomhlaza wemiphunga kwi-vitro.
1. Ukuqaliswa kokulawulwa komgangatho wereferensi yangaphakathi kwinkqubo inokubeka iliso ngokubanzi inkqubo yovavanyo kunye nokuqinisekisa umgangatho wokulinga.
2. Uvakalelo oluphezulu: izinga lokuguqulwa kwe-1% linokubonwa ngokuzinzileyo kwimvelaphi ye-3ng / μL yesisombululo sasendle se-nucleic acid reaction.
3. Ukucaciswa okuphezulu: akukho mpendulo enqamlezileyo kunye neziphumo zokubona uhlobo lwasendle lwe-DNA ye-genomic yabantu kunye nezinye iintlobo eziguqukayo.
| Inqaku lenqaku | Igama lemveliso | Inkcazo |
| HWTS-TM006 | IKit ye-EML4-ALK Fusion yeGene yoMntu yokuFumana (i-Fluorescence PCR) | Iimvavanyo ezingama-20/ikhithi Iimvavanyo ezingama-50/ikhithi |
| HWTS-TM007 | IKit ye-BRAF yoMntu ye-V600E yokuFundisa iNguqu (i-Fluorescence PCR) | Iimvavanyo ezingama-24/ikhithi Iimvavanyo ezingama-48/ikhithi |
| HWTS-TM009 | I-ROS1 ye-Fusion Gene Mutation yeKit yoMntu yokuFumana (i-Fluorescence PCR) | Iimvavanyo ezingama-20/ikhithi Iimvavanyo ezingama-50/ikhithi |
| HWTS-TM012 | I-EGFR yoMntu yeGene 29 yeKhithi yokubona iiNguqu (i-Fluorescence PCR） | Iimvavanyo ezili-16/ikhithi Iimvavanyo ezingama-32/ikhithi |
| HWTS-TM014 | KRAS 8 Ikhithi yokuFumana iiNguqu (Fluorescence PCR) | Iimvavanyo ezingama-24/ikhithi Iimvavanyo ezingama-48/ikhithi |
| HWTS-TM016 | IKit yoMntu ye-TEL-AML1 Fusion Gene Mutation Detection (Fluorescence PCR) | Iimvavanyo ezingama-24/ikhithi |
| HWTS-GE010 | I-BCR-ABL yoMntu ye-Fusion Gene Mutation Kit (Fluorescence PCR) | Iimvavanyo ezingama-24/ikhithi |
Ixesha lokuposa: Apr-17-2024