KRAS 8 Utshintsho

Utshintsho lwamanqaku kwi-gene ye-KRAS lufunyenwe kwinani leentlobo zethumba lomntu, malunga ne-17% ~ 25% yezinga lokuguqulwa kwe-tumor, i-15% ~ 30% yezinga lokuguqula kwizigulane zomhlaza wemiphunga, i-20% ~ 50% yezinga lokuguqulwa komhlaza we-colorectal. izigulane.Ngenxa yokuba iprotheyini ye-P21 efakwe kwi-K-ras gene ibekwe ezantsi kwendlela yokubonisa i-EGFR, emva kokuguqulwa kwe-K-ras ye-gene, indlela yokubonisa i-downstream isoloko ivuliwe kwaye ayichatshazelwa ngamachiza ajoliswe kuyo phezulu kwi-EGFR, okubangelwa ukuqhubeka. ukwanda okuyingozi kweeseli.Utshintsho kumfuza we-K-ras ngokubanzi lunika ukuxhathisa kwi-EGFR i-tyrosine kinase inhibitors kwizigulana ezinomhlaza wemiphunga kunye nokuchasana ne-anti-EGFR antibody amachiza kwizigulana ezinomhlaza we-colorectal.Ngo-2008, i-National Comprehensive Cancer Network (NCCN) yakhupha isikhokelo sonyango lomhlaza womhlaza, owabonisa ukuba iindawo eziguqukayo ezibangela ukuba i-K-ras isebenze ikakhulu ibekwe kwi-codons 12 kunye ne-13 ye-exon 2, kwaye kucetyiswa ukuba zonke izigulana ezinomhlaza ophambili we-metastatic colorectal zinokuvavanyelwa utshintsho lwe-K-ras phambi konyango.Ke ngoko, ukufunyaniswa okukhawulezileyo nokuchanekileyo kokuguqulwa kofuzo lwe-K-ras kubaluleke kakhulu kwisikhokelo samayeza ezonyango.Le khithi isebenzisa i-DNA njengesampulu yokufumanisa ukubonelela ngovavanyo olusemgangathweni lwesimo soguqulo, olunokunceda oogqirha ekuhloleni umhlaza we-colorectal, umhlaza wemiphunga kunye nezinye izigulana zethumba ezixhamla kumachiza ekujoliswe kuwo.Iziphumo zovavanyo lwekhithi zezereferensi yeklinikhi kuphela kwaye akufanele zisetyenziswe njengesiseko sodwa sonyango lwezigulane.Oogqirha kufuneka benze izigwebo ezibanzi kwiziphumo zovavanyo ngokusekelwe kwizinto ezifana nemeko yesigulane, izibonakaliso zamachiza, impendulo yonyango kunye nezinye izikhombisi zovavanyo lwebhubhoratri.