I-ENFR YAMSEBISO LWE-GA 29

Umhlaza wemiphunga uye waba ngunobangela ophambili wokusweleka komhlaza emhlabeni wonke, ngokusongela kakhulu impilo yabantu. I-akhawunti yomhlaza we-LIGY ye-LUGY ye-LUGE malunga ne-80% yezigulana zomhlaza eziphunga. I-EGFR okwangoku yeyona nto ibaluleke kakhulu kwi-molecular ebaluleke kakhulu kunyango lwe-LICMS engeyiyo encinci. Inkangeleko ye-ENFR inokuphakamisa ukukhula kwe-tumoor, umahluko, ukuhlasela, i-metastasis, i-anti-Apoptosis, kunye nokukhuthaza i-turuogenesis. I-EGFR Tyrosine Kinase Intense (i-TKI) ingayithintela indlela ye-EGFR-wokongeza i-autotrostias, ngokuthintela i-apoptos ye-apopt, inciphisa i-turus eumogeogedis, njl. Inani elikhulu lezifundo libonakalisile ukuba ukusebenza konyango lwe-EGFR-TKI inxulumene ngokusondeleyo nemeko ye-IGFRE TOORE, kwaye inokuvumela ngokukodwa ukukhula kweeseli ze-tumro nge-init yotshintsho lwethumbe kwi-ITFRE. I-EGRE ye-Gene ikwiingalo emfutshane ye-chromosome 7 (7p12), ngobude obugcwele i-200kb kwaye zinono-28. Ingingqi eguqukayo ikakhulu ifumaneka kwi-IT 18 ukuya kwi-21, i-CODSS 746 ukuya kwi-755 i-akhawunti ecimeyo malunga ne-45% kunye ne-akhawunti ye-L858 kwi-40% ukuya kwi-45% ukuya kwi-45%. Isikhokelo se-NCCN sokuxilongwa kunye nonyango lomhlaza ongenamncinci weseli Olu khuphiswano lovavanyo lusetyenziselwa ukukhokela ulawulo lwe-enpridermal yokukhula kweTyprine Kixit (i-EGFR-TKI) iZiyobisi, kwaye unike isiseko seyeza elibekiweyo kwizigulana ezinemihlambi engeyiyo yesele. Le kit isetyenziselwa kuphela ukutshintshwa kwezinto eziguqulweyo kwi-EGRR kwizigulana ezinemihla yomhlaza we-laphu. Iziphumo zovavanyo zezokubhekiswa kweklinikhi kuphela kwaye akufuneki zisetyenziswe njengesiseko sonyango lomntu ngamnye. Iiklinikhi kufuneka zithathele ingqalelo imeko yesigulana, iziyobisi iziyobisi, kunye nokunyanga ukusabela kunye nezinye izikhombisi zovavanyo lweelebhu kunye nezinye izinto zisetyenziselwa ukuqalisa iziphumo zovavanyo.