I-ROS1 yeFusion yoGuquko lweGene yoMntu

I-ROS1 yi-transmembrane tyrosine kinase yentsapho ye-insulin receptor.Ijini yokudityaniswa kwe-ROS1 iye yaqinisekiswa njengolunye uhlobo olubalulekileyo lomqhubi womhlaza wemiphunga weseli.Njengommeli we-subtype entsha ye-molecular subtype, iziganeko ze-ROS1 zofuzo lwe-fusion kwi-NSCLC Malunga ne-1% ukuya kwi-2% ye-ROS1 ikakhulu iphinda ihlelwe ngokutsha kwii-exons zayo ze-32, i-34, i-35 kunye ne-36. I-EZR, i-SLC34A2, kunye ne-SDC4, iya kuqhubeka nokusebenzisa ummandla we-ROS1 we-tyrosine kinase.I-ROS1 kinase engasebenzi ngokungaqhelekanga inokuvula iindlela zokubonisa ezisezantsi ezifana ne-RAS/MAPK/ERK, PI3K/Akt/mTOR, kunye ne-JAK3/STAT3, ngaloo ndlela ithatha inxaxheba ekwandeni, ukwahlula kunye ne-metastasis yeeseli zethumba, kunye nokubangela umhlaza.Phakathi kweenguqu ze-ROS1 ezidityanisiweyo, i-CD74-ROS1 ithatha malunga ne-42%, i-EZR ithatha malunga ne-15%, i-SLC34A2 i-akhawunti malunga ne-12%, kwaye i-SDC4 yenza malunga ne-7%.Uphononongo lubonise ukuba indawo yokubopha i-ATP ye-catalytic domain ye-ROS1 kinase kunye ne-ATP-binding site ye-ALK kinase ine-homology ukuya kwi-77%, ngoko ke i-ALK tyrosine kinase i-molecule encinci ye-inhibitor crizotinib kunye nokunye kunesiphumo esicacileyo sonyango. kunyango lwe-NSCLC ngokuguqulwa kwe-fusion ye-ROS1.Ngoko ke, ukufumanisa ukuguqulwa kwe-ROS1 fusion isisiseko kunye nesiseko sokukhokela ukusetyenziswa kweziyobisi ze-crizotinib.