Kras 8 utshintsho

I-Points yotshintsho kwi-KRAS ifunyenwe kwinani leentlobo zethumba lomntu, malunga ne-17% yexabiso le-25% kwi-Tumor, i-15% ~ 50% i-50% yereyithi yomhlaza womhlaza we-colorement izigulana. Kuba iprotein ye-P21 efakwe kwi-K-Ras Gene ifakwe downstam yendlela ye-IGFR, emva kokuguquka kwe-K-Ras String, indlela yokuhambahamba kwe-K-Retream ehlala isebenza kwaye ayichaphazeleki yiyo i-ERTFRE kwi-EGFR, ekhokelela ekuqhubekeni ukwenziwa kwecala leeseli. Ukuguquguquka kwi-K-Ras Gene Gene Gene Hunter kwi-EGFR Tyrosine Kinitors kwizigulana zomhlaza wemiphunga kunye nokuchasana ne-Anti-umz. Ngo-2008, inethiwekhi yesizwe ebanzi yomhlaza (i-NCCN) ikhuphe isikhokelo seklinikhi yomhlaza we-coloretal, ochaza ukuba iisayithi eziguqulweyo ezibangela ukuba i-K-Ras zisebenze ikakhulu kwi-codson 2, kwaye yacebisa ukuba Zonke izigulana ezinomhlaza we-coloretitic o phambili zinokuvavanywa kwi-K-Ras Recionation ngaphambi konyango. Ke ngoko, ukufunyanwa ngokukhawuleza kunye nokuchanekileyo kwe-K-RASS Transving ye-K-RASS ebaluleke kakhulu kubaluleke kakhulu kwizikhokelo zeClinist. Le khiti isebenzisa i-DNA njengesampulu yokuchonga ukubonelela ngovavanyo olufanelekileyo lwemeko yenguqu, enokunceda ekufundeni ekufundeni umhlaza we-coloretal, umhlaza wemiphunga kunye nezinye izigulana ezixhasayo. Iziphumo zovavanyo zekhithi zezokubhekiswa kweklinikhi kuphela kwaye akufuneki zisetyenziswe njengesiseko sonyango olunye lwezigulana. Iiklinikhi kufuneka zenze izigqibo eziqinisekileyo kwiziphumo zovavanyo ezijolise kwizinto ezinje ngemicimbi yesigulana, iimpawu zeziyobisi, impendulo yonyango, impendulo yonyango kunye nezinye izikhombisi zovavanyo lweelebhu.