KRAS 8 Utshintsho

Ukuguqulwa kweengongoma kwi-gene ye-KRAS kufunyenwe kwinani leentlobo ze-tumor yabantu, malunga ne-17% ~ 25% yezinga lokuguqulwa kwe-tumor, i-15% ~ 30% yezinga lokuguquka kwizigulane zomhlaza wemiphunga, i-20% ~ 50% yezinga lokuguqulwa kwezigulane zomhlaza we-colorectal. Ngenxa yokuba iprotheni ye-P21 efakwe kwi-K-ras gene ifumaneka ezantsi kwendlela yokubonisa i-EGFR, emva kokuguqulwa kofuzo lwe-K-ras, indlela yokubonisa i-downstream isoloko ivuliwe kwaye ayichatshazelwa ngamachiza ajoliswe kuyo anyukayo kwi-EGFR, okubangelwa ukwanda okungalunganga okuqhubekayo kweeseli. Utshintsho kumfuza we-K-ras ngokubanzi lunika ukuxhathisa kwi-EGFR tyrosine kinase inhibitors kwizigulana ezinomhlaza wemiphunga kunye nokuchasana ne-anti-EGFR antibody amachiza kwizigulana ezinomhlaza. Ngo-2008, i-National Comprehensive Cancer Network (NCCN) yakhupha isikhokelo seklinikhi somhlaza we-colorectal, ebonisa ukuba iziza zokuguqula ezenza ukuba i-K-ras isebenze ikakhulu ibekwe kwi-codons 12 kunye ne-13 ye-exon 2, kwaye kucetyiswa ukuba zonke izigulane ezinomhlaza we-metastatic colorectal zivavanyelwe unyango lwe-K-ras. Ke ngoko, ukufunyaniswa okukhawulezileyo nokuchanekileyo kokuguqulwa kofuzo lwe-K-ras kubaluleke kakhulu kwisikhokelo samayeza ezonyango. Le khithi isebenzisa i-DNA njengesampulu yokufumanisa ukubonelela ngovavanyo olusemgangathweni lwesimo soguqulo, olunokunceda oogqirha ekuhloleni umhlaza we-colorectal, umhlaza wemiphunga kunye nezinye izigulana zethumba ezixhamla kumachiza ekujoliswe kuwo. Iziphumo zovavanyo lwekhithi zezereferensi yeklinikhi kuphela kwaye akufanele zisetyenziswe njengesiseko sodwa sonyango lwezigulane. Oogqirha kufuneka benze izigwebo ezibanzi kwiziphumo zovavanyo ngokusekelwe kwizinto ezifana nemeko yesigulane, izibonakaliso zamachiza, impendulo yonyango kunye nezinye izikhombisi zovavanyo lwebhubhoratri.