I-cyp2c9 ye-cyp2c9 kunye neVKRC1 Pee Polymorphism
Igama lemveliso
I-HWTS-GE014-I-CYP2C ye-Cyp2c9 kunye neVKRC
Isatifiketi
I-CE / TFDA
Isipikumu
Imfazwe yi-anticougorsul of Anticouhlal esetyenziswayo kuhambo lweklinikhi okwangoku, oluzimisele ikakhulu kuthintelo kunye nonyango lwezifo zethambeka. Nangona kunjalo, imfazwe ineefestile zonyango ezinqongopheleyo kwaye yahluka kakhulu phakathi kohlanga kunye nabantu. Iinkcukacha-manani zibonise ukuba umahluko weedosi ozinzileyo kubantu obahlukileyo zinokuba ngaphezulu kwamaxesha angama-20. Ukuphendula okungapheliyo kuye kwenzeka nge-15.2% yezigulana ezithatha i-warfarin nyaka ngamnye, ukuba i-3.5% iphuhlise ukopha. Izifundo ze-pharmacovic zibonise ukuba i-polymorphism yemfuza ye-enzyme vkorc1 kunye ne-metabolic cyp2c9c ye-cyp2c9c ye-cypyme i-cyp2c9c ye-cyfarin yinto ebaluleke kakhulu echaphazela idosi yemfazwe. Imfazwe yi-infinin ye-vitamin k e-vitamin k e-vitamin k aptide (VKRC1), kwaye ngenxa yoko ithintele i-synthesing ye-cynthes equka i-vitamin k kwaye ibonelela nge-antickoaasing. Inani elikhulu lezifundo libonise ukuba i-gene polymorphism ye-VKRC1 ye-VKRC1 yeyona nto ibaluleke kakhulu echaphazela ugqatso kunye nomehluko kwidosi eyodwa kwi-Defarin yemfazwe. I-Warfarin ifikelela kwi-cyp2c9, kwaye iguqukile icocile kakhulu i-metabolism yemfazwe. Abantu abasebenzisa i-warfarin banomngcipheko ophezulu (kabini ukuya kumaxesha amathathu ngaphezulu) ukopha kwinqanaba lokuqala lokusebenzisa.
Ijelo
| Indlala | IVKRC1 (-1639G> A) |
| I-Cy5 | I-cyp2c9 * 3 |
| I-vic / hex | IC |
Iiparamitha zobugcisa
| Ukugcinwa | Ulwelo: ≤-18 ℃ |
| Beka ubomi kwishelufa | Iinyanga ezili-12 |
| Uhlobo locaphu | Igazi elitsha lase-Edta i-anticoed |
| CV | ≤5.0% |
| Indawo yokuhlala | 1.0ng / μl |
| Ubuchule | Akukho ntshukumo inqamlezayo kunye nolunye ulandelelwano olujikelezayo lwe-genome yomntu (i-cyp2c ye-cyp2c19, i-geneng gene); Ukuguqulwa kwe-cyp2c9 * 13 kunye neVKRC1 (3730G> A) ngaphandle koluhlu lwale kit |
| Izixhobo ezifanelekileyo | Faka isicelo se-biosystemsts 700 ye-PCR ye-PCR ye-PCR Faka isicelo se-biosystemsts ezingama-700 ngokukhawuleza kwe-PCR ye-PCR I-CARTUDIONIO®5 I-PAY-Time-Times Spish Spish I-Slan-96p yangempela ye-PCR ye-PCR I-FIMCYCLER ®480 ye-PALCR ye-PCR ye-PCR I-Linegene 9600 kunye neNkqubo yokufumana iPRRR Ma-6000 ubungakanani bexesha lokwenyani I-biorad cfx96 yeyokwenyani ye-PFRR I-biorad cfx opi 96 Inkqubo ye-PFR ye-PCR |
Ukuhamba komsebenzi
Ukucetyiswa Ukuqhekeza Ukuphinda Uhlengahlengiso: I-Macro kunye ne-Macro micro-Taki ye-Vi / i-HWS-3001, HWTS-3004- 3003 I-3006).
