I-Human Cytomegalovirus (HCMV) Nucleic Acid

I-Human cytomegalovirus (HCMV) lilungu eline-genome enkulu kusapho lwe-herpes virus kwaye inokufaka iiproteni ezingaphezu kwama-200. I-HCMV inqunyelwe kancinci kuluhlu lwayo lwabantu, kwaye akukabikho modeli yesilwanyana yosulelo lwayo. I-HCMV inomjikelo wokuphindaphinda ocothayo node ukwenza umzimba wokufakwa ngaphakathi kwenyukliya, kwaye iqalise ukuveliswa kwemizimba yokufakwa kwe-perinuclear kunye ne-cytoplasmic kunye nokudumba kweeseli (iiseli ezinkulu), yiyo loo nto ibizwa njalo. Ngokwe-heterogeneity ye-genome kunye ne-phenotype yayo, i-HCMV inokwahlulwa ibe ziintlobo ngeentlobo zeentlobo, phakathi kwazo kukho umahluko othile we-antigenic, nangona kunjalo, ongenamsebenzi weklinikhi.

Usulelo lwe-HCMV lusulelo oluqhelekileyo, olubandakanya amalungu amaninzi ngokwezonyango, luneempawu ezintsonkothileyo nezahlukeneyo, luhlala lungathethi nto, kwaye lunokubangela ukuba izigulana ezimbalwa zibe nezilonda zamalungu amaninzi kuquka i-retinitis, i-hepatitis, i-pneumonia, i-encephalitis, i-colitis, i-monocytosis, kunye ne-thrombocytopenic purpura. Usulelo lwe-HCMV luqhelekile kwaye lubonakala lusasazeka kwihlabathi liphela. Luxhaphake kakhulu kubemi, kunye namazinga okuxhaphaka angama-45-50% nangaphezulu kwama-90% kumazwe aphuhlileyo nasaphuhlayo, ngokwahlukeneyo. I-HCMV ingalala emzimbeni ixesha elide. Nje ukuba amandla omzimba okuzikhusela abuthathaka, intsholongwane iya kusebenza ukuba ibangele izifo, ngakumbi usulelo oluphindaphindayo kwizigulana ezine-leukemia kunye nezigulana ezifakelwe ezinye, kwaye inokubangela i-necrosis yezitho ezifakelwe ezinye kwaye ibeke ubomi bezigulane emngciphekweni kwiimeko ezinzima. Ukongeza ekuzalweni, ukukhulelwa okuphumileyo kunye nokuzala ngaphambi kwexesha ngosulelo lwangaphakathi kwesibeleko, i-cytomegalovirus inokubangela ukukhubazeka kokuzalwa, ngoko ke usulelo lwe-HCMV luyakwazi ukuchaphazela unyango lwangaphambi kokuzalwa kunye nomgangatho wabemi.