I-CYP2C19 yoMntu yeGene Polymorphism

I-CYP2C19 yenye yezobisi ezibalulekileyo ze-metabolizing enzymes kwintsapho ye-CYP450. Uninzi lwe-endogenous substrates kunye malunga ne-2% yeziyobisi zeklinikhi zixutywe yi-CYP2C19, ezifana ne-metabolism ye-antiplatelet aggregation inhibitors (njenge-clopidogrel), i-proton pump inhibitors (i-omeprazole), i-anticonvulsants, njl. Olu tshintsho lwamanqaku e-*2 (rs4244285) kunye ne-3 (rs4986893) lubangela ukulahleka komsebenzi we-enzyme encoded yi-CYP2C19 gene kunye nobuthathaka besakhono se-substrate ye-metabolic, kunye nokwandisa ukuxininisa kwegazi, ukwenzela ukuba kubangele ukusabela okubi kweziyobisi ezinxulumene nokugxilwa kwegazi. * I-17 (rs12248560) inokunyusa umsebenzi we-enzyme ekhowudiweyo yi-CYP2C19 gene, imveliso ye-metabolites esebenzayo, kunye nokuphucula i-platelet aggregation inhibition kunye nokwandisa ingozi yokopha. Kubantu abane-metabolism ecothayo yamachiza, ukuthatha iidosi eziqhelekileyo ixesha elide kuya kubangela ityhefu eyingozi kunye nemiphumo emibi: ubukhulu becala umonakalo wesibindi, umonakalo wenkqubo ye-hematopoietic, umonakalo wenkqubo ye-nervous central, njl., Oku kunokukhokelela ekufeni kwiimeko ezinzima. Ngokomahluko ngamnye kwimetabolism yeziyobisi ehambelanayo, ngokuqhelekileyo ihlulwe ibe yi-phenotypes ezine, ezizezi ultra-fast metabolism (UM, *17/*17,*1/*17), i-metabolism ekhawulezayo (RM,*1/*1) , i-metabolism ephakathi (IM, *1/*2, *1/*3), i-metabolism ecothayo (PM, *2/*3/*2, *2/).