I-Methylated yomntu NDRG4/SEPT9/SFRP2/BMP3/SDC2 Gene

Kubantu abadala, ngaphezu kwe-10 8 iiseli ze-epithelial zamathumbu ziwela eludongeni lwamathumbu yonke imihla, kwaye zikhutshwe kunye nendle nge-peristalsis enkulu yamathumbu.Ngenxa iiseli ithumba kusenokwenzeka ukuba bawe kwi iphecana wamathumbu ukwanda engaqhelekanga, isitulo izigulana ithumba emathunjini iqulathe iiseli ezininzi ezigulayo kunye namacandelo iiseli engaqhelekanga, nto leyo isiseko eziphathekayo ukubhaqa isitulo esizinzileyo.Uphononongo lufumene ukuba ukuguqulwa kwe-methylation yabakhuthazi bemfuza sisiganeko sokuqala kwi-tumorigenesis, kwaye izinto zofuzo ezifunyenwe kwiisampulu zesitulo sezigulane ezinomhlaza we-colorectal zingabonakalisa ubukho bomhlaza emathunjini ngaphambili.

I-NDRG4, eyaziwa ngokuba yi-SMAP-8 kunye ne-BDM1, ingomnye wamalungu amane e-NDRG gene family (NDRG1-4), ebonakaliswe ukuba idibene nokwanda kweeseli, ukuhlukana, ukuphuhliswa kunye noxinzelelo.Kuqinisekisiwe ukuba i-NDRG4 methylation yinto enokubakho ye-biomarker yokubhaqwa okungahlaseli komhlaza we-colorectal kwiisampuli zesitulo.

I-SEPT9 lilungu lentsapho ye-Septin yemfuza, equkethe ubuncinane i-13 yofuzo efaka i-domain ye-GTPase egciniweyo enokuthi ibophe iiprotheni ezinxulumene ne-cytoskeleton, kwaye idibene nokwahlulwa kweseli kunye ne-tumorigenesis.Uphononongo lufumene ukuba umxholo we-methylated Septin9 wofuzo wonyuswa ngokwesiqhelo kwiisampulu zesitulo kwizigulana ezinomhlaza obala.

Iiprotheyini ezinxulumene ne-frizzled-related frizzled (sFRPs) ziiprotheni ezinyibilikayo eziyiklasi ye-Wnt pathway antagonists ngenxa ye-homology ephezulu yesakhiwo kwi-frizzled (Fz) receptor ye-Wnt signaling.Ukungasebenzi kwemfuza ye-SFRP kubangela ukusetyenziswa okungalawulwayo kwe-Wnt yokubonisa ehambelana nomhlaza wesisu.Okwangoku, i-SFRP2 methylation kwi-stool inokusetyenziswa njenge-biomarker engahlaseliyo yokuxilongwa komhlaza we-colorectal.

I-BMP3 lilungu le-TGF-B superfamily kwaye ngaloo ndlela idlala indima ebalulekileyo kuphuhliso lwe-embryonic ngokukhuthaza kunye nokubumba ukwakheka kwamathambo kwangethuba.I-BMP3 yi-hypermethylated kumhlaza webala kwaye inokusetyenziswa njengephawu elibalulekileyo lethumba.

I-SDC2 yiseli yomphezulu we-heparan sulfate proteoglycan ebandakanyeka kulawulo lweenkqubo ezininzi ze-physiological and pathological.Ukucutshungulwa ngokomzimba kubandakanya ukwanda kweeseli, ukwahlula, ukubambelela, umbutho we-cytoskeletal, ukufuduka, ukuphulukiswa kwesilonda, ukunxibelelana kwe-cell-matrix, i-angiogenesis;Iinkqubo ze-Pathological ziquka ukuvuvukala kunye nomhlaza.Inqanaba le-methylation ye-SDC2 yofuzo kwizicubu zomhlaza we-colorectal laliphezulu kakhulu kunelo lihlala kwizicubu eziqhelekileyo.